|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carriage of rs738409:G in PNPLA3 is associated with an increased risk of developing alcohol-related cirrhosis and has a significant negative effect on survival.
|
28161471 |
2017 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.
|
29535416 |
2018 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Whether the PNPLA3 rs738409 polymorphism could be a risk factor for the development of hepatocellular carcinoma (HCC) in cirrhosis patients is unknown.
|
21745286 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No significant differences in the genotype distribution of PNPLA3 (P = 0.90) or TM6SF2 (P = 0.72) were observed between patients with cirrhosis and patients without cirrhosis.
|
30161167 |
2018 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TM6SF2 C/T or T/T in conjunction with PNPLA3 G/G variants may be potential genetic risk factors for developing HCC in alcohol-related cirrhosis.
|
26493626 |
2016 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 CG/GG SNP at rs738409 was significantly associated with the presence of cirrhosis (odds ratio [OR], 1.76; 95% confidence interval [CI], 1.34-2.30), after adjusting for age, sex, diabetes, and race.
|
26305067 |
2016 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Correction: Genetic Variants in PNPLA3 and TM6SF2 Predispose to the Development of Hepatocellular Carcinoma in Individuals With Alcohol-Related Cirrhosis.
|
29895985 |
2018 |
|
Liver Cirrhosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Personalized strategies employing the genetic risk conferred by ATG16L1 and PNPLA3 may be used for risk-based surveillance in cirrhosis.
|
31484215 |
2019 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance.
|
22863264 |
2012 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 Genetic Variant rs738409 Influences the Progression to Cirrhosis in HIV/Hepatitis C Virus Coinfected Patients.
|
27973562 |
2016 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis pooled four studies with 1135 cases of chronic hepatitis B (CHB) to evaluate the impact of PNPLA3 SNP on liver steatosis and also pooled five studies with 3713 cases of CHB to evaluate the impact of PNPLA3 SNP on cirrhosis.
|
29218813 |
2018 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis.
|
22719190 |
2012 |
|
Liver Cirrhosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Among them, 86 patients who were followed up for >5 years and without liver cirrhosis were analyzed to clarify the relationship between PNPLA3 genotype and long-term changes in biomarkers.
|
27862719 |
2017 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among 270 HBV-infected patients, concurrent fatty liver was found in 107 patients (39.6%) and was associated with metabolic risks, cirrhosis (P = 0.016) and PNPLA3 rs738409 CG/GG genotype (P = 0.002).
|
27547913 |
2017 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Homozygous carriers of the PNPLA3 variant are prone to develop cirrhosis in the absence of other risk factors such as alcohol or viral hepatitis.
|
24222094 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 genotypes were also associated with higher risk of developing liver fibrosis and cirrhosis in dominant (aOR: 1.98, P=2.20*10-5; aOR: 1.67, P=0.008, respectively) and recessive (aOR: 3.94, P=5.16*10-5; aOR: 3.02, P=0.003, respectively) models.
|
28338112 |
2017 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n=1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and PNPLA3 rs738409 genotype), with advanced hepatic fibrosis/cirrhosis.
|
24978903 |
2014 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of note, the PNPLA3 risk variant advances fibrosis in the total cohort as well as in the subgroups of patients with viral hepatitis and non-viral liver diseases and contributes 16% of the total cirrhosis risk.
|
21168459 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identified variants in the MBOAT7 (P = 1.03 × 10(-9)) and TM6SF2 (P = 7.89 × 10(-10)) genes as new risk loci and confirmed rs738409 in PNPLA3 as an important risk locus for alcohol-related cirrhosis (P = 1.54 × 10(-48)) at a genome-wide level of significance.
|
26482880 |
2015 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Moreover, PNPLA3 148M allele carriers showed an increased incidence of cirrhosis (P-value < 0.001).
|
24102786 |
2014 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 I148M was associated with a stepwise increase in liver fat content of up to 28% in MM vs. II-homozygotes (P-trend = 0.0001) and with ORs of 2.03 (1.52-2.70) for NAFLD (P = 3×10-7), 3.28 (2.37-4.54) for cirrhosis (P = 4×10-12), and 0.95 (0.86-1.04) for IHD (P = 0.46).
|
29228164 |
2018 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
According to ultrasound examinations, no association between PNPLA3 rs738409 genotype and fatty change of the liver or hepatic cirrhosis was found in Japanese patients infected with HCV.
|
24349054 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that patients at risk for liver cirrhosis may benefit from PNPLA3 genotyping and thus more intensive monitoring if the rs738409 C>G polymorphism is identified.
|
25378656 |
2015 |