|
Malignant neoplasm of breast
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutants dl312, dl314, hr1, and hr3 with mutations in region E1A of adenovirus type 5 were defective for the induction of cell cycle abnormalities detectable by flow cytometry, cell DNA replication, thymidine kinase production, and chromosome aberrations and did not synthesize the viral DNA-binding protein (E2A) in rat cells. dl311, a leaky E1A mutant, induced cell cycle effects at high multiplicity in only one of three experiments, and synthesized the DNA-binding protein. hr7 (E1B) gave a wild-type response in all tests. dl313 was also positive in all tests, although it induced fewer polyploid cells than did wild-type virus, probably because of the leftward extension of the dl313 E1B deletion into E1A. sub315 and sub316, with mutations which also span the E1A-E1B border, synthesized DNA-binding protein, but caused no cell cycle alterations detectable by flow cytometry in rat or mouse cells.
|
6823012 |
1983 |
|
Beckwith-Wiedemann Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on their map position, several of these ZNF genes are putative candidate genes for both developmental and malignant disorders: ZNF138, ZNF139, and ZNF143 were localized to 7q11.2, 7q21.3-q22.1, and 11p15.3-p15.4, regions involved in deletions and/or translocations associated with Williams syndrome, split hand and foot disease (SHFD1), and Beckwith-Wiedemann syndrome, respectively.
|
7557990 |
1995 |
|
Foot Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Based on their map position, several of these ZNF genes are putative candidate genes for both developmental and malignant disorders: ZNF138, ZNF139, and ZNF143 were localized to 7q11.2, 7q21.3-q22.1, and 11p15.3-p15.4, regions involved in deletions and/or translocations associated with Williams syndrome, split hand and foot disease (SHFD1), and Beckwith-Wiedemann syndrome, respectively.
|
7557990 |
1995 |
|
Williams Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on their map position, several of these ZNF genes are putative candidate genes for both developmental and malignant disorders: ZNF138, ZNF139, and ZNF143 were localized to 7q11.2, 7q21.3-q22.1, and 11p15.3-p15.4, regions involved in deletions and/or translocations associated with Williams syndrome, split hand and foot disease (SHFD1), and Beckwith-Wiedemann syndrome, respectively.
|
7557990 |
1995 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore replacement of part of the amino-terminal kinase regulatory domain of ATF-1 protein with EWS regulatory domain results in an altered DNA binding, protein-protein interactions and transcriptional activation properties of EWS-ATF-1 causing deregulated gene expression which may be responsible for the genesis of t(12;22) chromosome translocation-bearing human solid tumors.
|
8552387 |
1996 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, we isolated a splicing variant of dbpA as a candidate for the cellular recombinogenic protein that leads to genomic instability and inflammation-mediated hepatocarcinogenesis.
|
12239625 |
2002 |
|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, it has been shown that both XPC and UV-DDB are ubiquitylated in response to UV irradiation of cells.
|
16793369 |
2006 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, we have identified a new member of KRAB-ZNF superfamily with growth-inhibitory ability and its downregulation may contribute to carcinogenesis.
|
17137575 |
2007 |
|
Gastrointestinal Stromal Tumors
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Importantly, 10 KRAB-ZNF genes mapped to a single locus on chromosome 19p, and a subset predicted likely response to imatinib mesylate-based therapy in a naïve panel of GIST.
|
19671739 |
2009 |
|
Gastrointestinal Stromal Tumors
|
0.030 |
Biomarker
|
group |
BEFREE |
These screens identified seventeen "IM sensitizing genes" in GIST cells (sensitization index (SI) <0.85 ratio of drug/vehicle) with a false discovery rate (FDR) <15%, including twelve ZNF genes, the majority of which are located within the HSA19p12-13.1 locus.
|
23372733 |
2013 |
|
Carcinogenesis
|
0.050 |
PosttranslationalModification
|
phenotype |
BEFREE |
In summary, these studies associate toxicant exposure with widespread silencing of ZNF genes by DNA hypermethylation-linked H3K9me3 spreading, further implicating epigenetic dysfunction as a driver of toxicant associated carcinogenesis.
|
23974009 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.030 |
AlteredExpression
|
group |
BEFREE |
GSTT1 copy number gain and ZNF overexpression are predictors of poor response to imatinib in gastrointestinal stromal tumors.
|
24124608 |
2013 |
|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
BEFREE |
Together, our results show that KAP1-mediated stimulation of multiple KRAB-ZNF contributes to the growth and metastasis of breast cancer.
|
25421577 |
2015 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Together, our results show that KAP1-mediated stimulation of multiple KRAB-ZNF contributes to the growth and metastasis of breast cancer.
|
25421577 |
2015 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, our results show that KAP1-mediated stimulation of multiple KRAB-ZNF contributes to the growth and metastasis of breast cancer.
|
25421577 |
2015 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Although the distinct biological functions of most KRAB-ZNF proteins remain unknown, recent publications indicate their implication in fundamental processes, such as cell proliferation, apoptosis, differentiation, development, and tumorigenesis.
|
26738774 |
2016 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Zinc finger (ZNF) proteins, a diverse family of proteins, have multiple biological functions in cancer.
|
27655485 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Zinc finger (ZNF) proteins, a diverse family of proteins, have multiple biological functions in cancer.
|
27655485 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.
|
27928708 |
2017 |
|
External exotoses
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moderate exercise increased BMP-2, BMP-4, BMP-6, BMP receptor 2, pSmad-5, and inhibitor of DNA binding protein-1 expression in the superficial zone chondrocytes and suppressed cartilage degeneration, osteophyte growth, SB damage, and osteoclast-mediated SB resorption.
|
27965139 |
2017 |
|
Osteophyte
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moderate exercise increased BMP-2, BMP-4, BMP-6, BMP receptor 2, pSmad-5, and inhibitor of DNA binding protein-1 expression in the superficial zone chondrocytes and suppressed cartilage degeneration, osteophyte growth, SB damage, and osteoclast-mediated SB resorption.
|
27965139 |
2017 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus.
|
28582864 |
2017 |
|
Rett Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Methyl-CpG-binding protein 2 (MeCP2) is a multifunctional methylated DNA binding protein; mutation of which causes Rett syndrome, a severe neurodevelopmental disorder.
|
28616777 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
As a typical member of KRAB-ZNFs, dysregulation of ZNF300 contributes to multiple pathologies such as leukemia and cancer.
|
28670441 |
2017 |