|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.310 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, ARQ 531 was found to increase survival over ibrutinib in a murine Eμ-TCL1 engraftment model of CLL and a murine Eμ-MYC/TCL1 engraftment model resembling Richter transformation.
|
30093506 |
2018 |
|
Richter's syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, ARQ 531 was found to increase survival over ibrutinib in a murine Eμ-TCL1 engraftment model of CLL and a murine Eμ-MYC/TCL1 engraftment model resembling Richter transformation.
|
30093506 |
2018 |
|
Hyperplastic lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hyperplastic lymph node and tonsil also exhibit strong TCL1 protein expression in mantle zone B cells and in rare interfollicular zone cells, whereas follicle-center B cells (centroblasts and centrocytes) show weaker expression.
|
10449776 |
1999 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell prolymphocytic leukaemia (T-PLL) is a sporadic, mature T-cell disorder in which there is usually an aberrant T-cell receptor alpha (TCRA) rearrangement that activates the TCL1 or MTCP1-B1 oncogenes.
|
11054065 |
2000 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL) is consistently associated with inactivation of the ATM gene and chromosomal re-arrangements leading to an overexpression of MTCP1/TCL1 oncoproteins.
|
18073348 |
2008 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell leukemia/lymphoma protein 1 (TCL1) was recently shown to display an expression pattern in chronic lymphocytic leukemia (CLL) corresponding to molecular subtypes, where poor-risk patients demonstrated higher expression levels.
|
19889012 |
2010 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell leukemia 1A (TCL1A) was the gene closest (926-7000 bp) to the four SNPs.
|
20876420 |
2010 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T cell leukemia 1a (TCL1a) (14q32.1) may be implicated in this case.
|
21505955 |
2011 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell leukemia/lymphoma 1 (TCL1) is an oncogene overexpressed in T-cell prolymphocytic leukemia and in B-cell malignancies including B-cell chronic lymphocytic leukemia and lymphomas.
|
23160471 |
2013 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL) is an aggressive post-thymic T-cell malignancy characterized by the recurrent inv(14)(q11q32)/t(14;14)(q11;q32) or t(X;14)(q28;q11) leading to activation of either the TCL1 or MTCP1 gene, respectively.
|
24446122 |
2014 |
|
T-cell lymphoblastic leukemia/lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRγ-TCL1A translocation]: a case report and a review of the literature.
|
24966976 |
2014 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell leukemia/lymphoma protein 1 (TCL1) is expressed by several B-cell lymphomas, including MCL.
|
25688912 |
2015 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and transgenic mouse studies indicate that activation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease.
|
27071132 |
2016 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways.
|
30151355 |
2018 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MTCP1 putative oncogenes, respectively.
|
8634440 |
1996 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature T-cell leukemia associated with chromosomal rearrangements implicating MTCP1 or TCL1 genes.
|
9657733 |
1998 |
|
Lymphoma, AIDS-Related
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.
|
10449776 |
1999 |
|
Lymphoid hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma.
|
11304575 |
2001 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TCL1: a new drug target in lymphoid and germ-cell malignancies?
|
12962701 |
2003 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tcl1 as a model for lymphomagenesis.
|
15325703 |
2004 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TCL1 expression patterns in CLL are complex and highly dynamic and appear to reflect both the histogenetic subtypes of the disease and the growth parameters of individual tumors.
|
16341048 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TCL1 expression patterns in CLL are complex and highly dynamic and appear to reflect both the histogenetic subtypes of the disease and the growth parameters of individual tumors.
|
16341048 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.
|
17178851 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.
|
17178851 |
2006 |