|
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
MIA and GW112 were overexpressed in 10 (25%) and 22 (55%) of 40 GC samples, and the overexpression of these two genes was associated with tumor stage, respectively.
|
16210872 |
2005 |
|
Malignant neoplasm of stomach
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Levels of MIA were raised in a small proportion of serum samples from patients with GC (4/69, 5.8%).
|
16331256 |
2006 |
|
Malignant neoplasm of stomach
|
0.320 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Femur Head Necrosis
|
0.200 |
Biomarker
|
disease |
RGD |
New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model.
|
20579363 |
2010 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The melanoma inhibitory activity (MIA) protein is a clinically valuable marker in patients with malignant melanoma as enhanced values diagnose metastatic melanoma stages III and IV.
|
12592021 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MIA has a pivotal role in the progression and metastasis of melanoma; MIA2 and TANGO have been suggested to possess tumor-suppressive functions; and OTOR is uniquely expressed in cochlea of the inner ear.
|
29655307 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Uncovering new potential downstream effectors working via activation of YBX1 supports the important role of MIA in melanoma.
|
23672612 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The protein from human melanoma cell lines and tumors is called melanoma inhibitory activity (MIA) (Blesch et al.[1994] Cancer Res.
|
9097023 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, PEDF downregulated S100β and melanoma inhibitory activity, which are widely used in the pathological diagnosis of melanoma.
|
21673604 |
2011 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seven human tumour xenografts were analysed in nude mice; five tumours (KEsC-2, oesophageal carcinoma; FA-6, pancreatic carcinoma; SEKI, melanoma; Lu-65A and Lu-61, lung carcinomas) were associated with hypercalcaemia and two tumours (MIA PaCa-2, pancreatic carcinoma; PLC/PRF/5, hepatocellular carcinoma) with normocalcaemia.
|
1997102 |
1991 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
We compared 3 tumor markers, TA90-immune complex (TA90IC), melanoma-inhibiting activity (MIA) protein, and S100B protein in Stage III melanoma patients undergoing adjuvant vaccine immunotherapy.
|
17661202 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All melanomas tested (n = 19) expressed high levels of MIA mRNA and protein.
|
12014625 |
2002 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of COOH-terminal binding protein expression in malignant melanomas leads to induction of MIA expression.
|
12384563 |
2002 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected].
|
12230496 |
2002 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Multimarker real-time reverse transcription-PCR for quantitative detection of melanoma-associated antigens: a novel possible staging method.
|
18181974 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these findings suggest that cadherin-7 regulates the expression and activity of MIA and the migration of melanoma cells playing a role in tumor development of malignant melanoma.
|
19200257 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In summary, our study proves HMG1 and p65 to be important factors in MIA regulation and melanoma progression.
|
12665595 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma inhibitory activity (MIA) has been shown to play an essential role in the progression of malignant melanoma and to influence melanoma-associated molecules and pathways in the early tumor formation steps.
|
21642354 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Melanoma inhibitory activity (MIA) is an 11 kD protein secreted by malignant melanomas.
|
15386421 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To provide direct evidence that MIA plays a role in metastasis of malignant melanomas, A-mel 3 hamster melanoma cells were transfected with sense- and antisense rhMIA cDNA and analysed subsequently for changes in their tumorigenic and metastatic potential.
|
11027436 |
2000 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We compared MIA serum levels in two groups of patients with primary melanoma; those with positive as opposed to those with negative sentinel lymph nodes.
|
18477894 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified melanoma inhibitory activity (MIA) as a direct target gene of SOX10, which is an essential protein for melanoma cell migration and invasion.
|
24608986 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the melanoma mouse model Tg(Grm1), MIA-deficient mice supported the impact of MIA on senescence by showing a significantly earlier tumor onset compared to controls.
|
31172672 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
These results suggest that expression of MIA promotes melanoma progression by inducing further melanoma-associated genes.
|
15208686 |
2004 |