|
Obesity, Morbid
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aims were to evaluate the outcomes of TKR surgery and the risks for post-operative complications in patients with morbid obesity (BMI > 40 kg/m<sup>2</sup>) as compared with obese patients (30 < BMI ≤ 40 kg/m<sup>2</sup>) and non-obese patients, BMI < 30 kg/m<sup>2</sup>); to evaluate if there are differences between morbid-obese patients (BMI 40-49.99 kg/m<sup>2</sup>) and extreme morbid obese patients (BMI > 50 kg/m<sup>2</sup>); and to present some surgical tips which can improve the TKR outcomes in morbid obese patients.
|
31372812 |
2020 |
|
Surgical incision wound (morphologic abnormality)
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was a slight increased risk of early complications following TKR in morbid obese patients such as skin necrosis and infection around the surgical incision.
|
31372812 |
2020 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data support the hypothesis that TKTL1 and TKTL2 are functional transketolases and represent novel therapeutic targets for diabetes and cancer.
|
30646877 |
2019 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data support the hypothesis that TKTL1 and TKTL2 are functional transketolases and represent novel therapeutic targets for diabetes and cancer.
|
30646877 |
2019 |
|
Nodule
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
An appropriate cavity and a hydrophobic nodule were also present in TKTL1/2, into which the diphosphate group fitted, and that was implicated in aminopyrimidine and thiazole ring binding in TKT, respectively.
|
30646877 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TKT and TKTL1 were significantly higher in ADC than in non-tumor tissue (p < 0.001).
|
30032820 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further studies are necessary to examine whether strategies that antagonize TKTL1 function will be able to restore the sensitivity of glioma cells towards irradiation and antiangiogenic therapies in the more complex in vivo environment.
|
30044385 |
2018 |
|
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with responders, nine coding genes (BPI, DEFA1B, DEFA4, CEACAM8, MMP8, FOLR3, LTF, TCN1 and TKTL1) were significantly up-regulated in non-responders at all 5 time points, which could probably be the characteristic genes in hepatitis B vaccine non-responsiveness.
|
29580160 |
2018 |
|
Neuralgia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Patients with knee OA with neuropathic pain-like symptoms identified using the PainDETECT questionnaire are most at risk of developing chronic postoperative pain after TKR surgery.
|
29920331 |
2018 |
|
Chronic postoperative pain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with knee OA with neuropathic pain-like symptoms identified using the PainDETECT questionnaire are most at risk of developing chronic postoperative pain after TKR surgery.
|
29920331 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients undergoing TKR had an average age of 69 years; 61% were women, 93% were white, and 25% were severely or morbidly obese.
|
28719557 |
2017 |
|
Mucinous Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of TKTL1 associated with high Dukes stage, non-mucinous adenocarcinoma, and left-sided disease.
|
26650256 |
2016 |
|
Tumor Promotion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our data provide evidence for an important role of TKTL1 in aerobic glycolysis and tumor promotion in melanoma that may result from defective promoter methylation.
|
26907172 |
2016 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The percentage of positive TKTL1 and p63 expression in gastric carcinomas was significantly higher than that in normal gastric mucosa tissues (P < 0.05).
|
26406948 |
2015 |
|
Multiple tumors
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
It is well known that tumor cells mainly depend on the nonoxidative pathway of the pentose phosphate pathway (PPP), and transketolase-like 1 (TKTL1), a kind of crucial metabolism enzyme, participates in the regulation of PPP; notably, overwhelming evidence has demonstrated that TKTL1 plays pivotal roles in the development and progression of multiple tumors.
|
26032094 |
2015 |
|
Carcinoma of urinary bladder, invasive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression patterns and prognostic role of transketolase-like 1 in muscle-invasive bladder cancer.
|
25572961 |
2015 |
|
Blast Phase
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TKTL1 expression levels appear to decline in the course of CML with lowest levels during BC.
|
24390277 |
2014 |
|
Cerebral Palsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Baseline TKTL1 expression in CP patients did not have value in prognostication of subsequent favourable or dismal outcome.
|
24390277 |
2014 |
|
Craniofacial Dysostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel FGFR2 mutation associated with tyrosine kinase II (TK-II) domain, L617F, was found in one Crouzon syndrome patient by direct PCR sequencing.
|
23913723 |
2014 |
|
Myeloid Leukemia, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A significantly lower TKTL1 expression was found in chronic phase (CP) CML patients compared to healthy controls.
|
24390277 |
2014 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of transketolase-like gene 1 (TKTL1) on RNA and protein level has been linked to tumour progression, metastasis and unfavourable patient outcome in many solid tumours.
|
24390277 |
2014 |
|
Cleft palate, isolated
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Baseline TKTL1 expression in CP patients did not have value in prognostication of subsequent favourable or dismal outcome.
|
24390277 |
2014 |
|
Craniofacial dysostosis type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel FGFR2 mutation associated with tyrosine kinase II (TK-II) domain, L617F, was found in one Crouzon syndrome patient by direct PCR sequencing.
|
23913723 |
2014 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We identified increased TKTL1 protein levels in malignant conjunctival tumors compared with control samples and detected an average IRS of 1.78 (standard deviation [SD], ± 0.46) for melanomas, 1.3 for lymphomas (SD, ± 0.79), and 1.22 for squamous cell carcinomas (SD, ± 0.
|
22658715 |
2012 |
|
Endometrial Stromal Sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Considering that the responsiveness to tyrosine kinase inhibitors is known to be related to the presence of specific activating mutations or gene over-expression, which are not detectable in ESS, TKRs immunohistochemical over-expression alone should not be considered as a reliable marker for targeted therapies in ESS.
|
23018215 |
2012 |