|
Liver diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
<b>Background</b>: Higher liver caspase-3 activity has been found in patients with different liver diseases.
|
31084510 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Tand-scFv<sub>Sca-1+GPIIb/IIIa</sub> is a promising candidate to enhance therapeutic cell delivery in order to promote myocardial regeneration and thereby preventing heart failure.
|
28900504 |
2017 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Tand-scFv<sub>Sca-1+GPIIb/IIIa</sub> is a promising candidate to enhance therapeutic cell delivery in order to promote myocardial regeneration and thereby preventing heart failure.
|
28900504 |
2017 |
|
Fibrosis, Liver
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> The novel findings of this study suggested that SA-A could reduce liver fibrosis and the molecular mechanisms behind it are closely associated with the regulation of PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways.
|
31213776 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusions</b>: Our study is the first one reporting data of circulating caspase-3 levels prior to LT for HCC, and an association between high serum caspase-3 levels previously to LT and survival at first year after LT.
|
31084510 |
2019 |
|
Middle Cerebral Artery Occlusion
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<B>Conclusions</B>: These findings suggest that maternal hypoxia may exacerbate hippocampal cell apoptosis in rat offspring after MCAO via alterations in the expression of cytochrome c, caspase-3, Bax, and bcl-2, which ultimately affects ischemic stroke prognosis.
|
29363906 |
2017 |
|
Carotid artery occlusion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
<b>Material and methods:</b> We evaluated outcomes of acutely administered modafinil on post-stroke behaviors and histopathological features (including apoptotic caspase-3 expressing neurons) through bilateral common carotid artery occlusion in rats.
|
31542978 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods</b>: In this study, we evaluated for the first time the prognostic value of Plk1 mRNA and protein expression in combination with the <i>TP53</i> mutation status (next generation sequencing), induction of apoptotic cell death (immunohistochemistry for cleaved caspase 3) and hypoxia (immunohistochemistry for carbonic anhydrase IX (CA IX)) in 98 NSCLC adenocarcinoma patients.
|
28638459 |
2017 |
|
Adenocarcinoma
|
0.080 |
Biomarker
|
group |
BEFREE |
<b>Methods</b>: In this study, we evaluated for the first time the prognostic value of Plk1 mRNA and protein expression in combination with the <i>TP53</i> mutation status (next generation sequencing), induction of apoptotic cell death (immunohistochemistry for cleaved caspase 3) and hypoxia (immunohistochemistry for carbonic anhydrase IX (CA IX)) in 98 NSCLC adenocarcinoma patients.
|
28638459 |
2017 |
|
Leptospirosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> The control group differed significantly from the leptospirosis and septic shock patients which demonstrate strong similarities: diffuse congestion in the red pulp with a moderate to intense infiltration of plasma cells and polymorphonuclear cells; follicles with marked atrophy; high density of CD20<sup>+</sup> cells; low density of NK, TCD4<sup>+</sup> and active caspase-3 positive cells and strong expression of IL-10; leptospirosis patients had higher S100 and TNF-α positive cells in the spleen than the other groups.
|
31114579 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> The expression of caspase-3 in breast cancer cells was increased when co-incubated with macrophages in the presence of M1-Exos <i>in vitro</i>.
|
31037133 |
2019 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> The expression of caspase-3 in breast cancer cells was increased when co-incubated with macrophages in the presence of M1-Exos <i>in vitro</i>.
|
31037133 |
2019 |
|
Malignant neoplasm of liver
|
0.270 |
AlteredExpression
|
disease |
BEFREE |
<i>Cnidium officinale</i> Makino extract induces apoptosis through activation of caspase-3 and p53 in human liver cancer HepG2 cells.
|
28966688 |
2017 |
|
Adult Liver Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
<i>Cnidium officinale</i> Makino extract induces apoptosis through activation of caspase-3 and p53 in human liver cancer HepG2 cells.
|
28966688 |
2017 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
<i>Cnidium officinale</i> Makino extract induces apoptosis through activation of caspase-3 and p53 in human liver cancer HepG2 cells.
|
28966688 |
2017 |
|
Lung Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
<i>Igfbp3</i>-null mice had increased lung tumor burden (>2-fold) and only half of human lung cancer cells survived after expression of IGFBP3, which corresponded to increased cleaved caspase-3 (10-fold), inactivation of IGF1 and MAPK signaling.
|
28330997 |
2017 |
|
Triple Negative Breast Neoplasms
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
<i>In silico</i> analysis suggested that <i>OTUD7B</i> regulation, probably owing to miR-1180 downregulation, may negatively regulate the NF-κB-Lin28 axis which in turn triggers Let-7 microRNA-mediated caspase-3 downregulation, thereby conferring paclitaxel resistance in TNBCs.
|
29416635 |
2018 |
|
Triple-Negative Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
<i>In silico</i> analysis suggested that <i>OTUD7B</i> regulation, probably owing to miR-1180 downregulation, may negatively regulate the NF-κB-Lin28 axis which in turn triggers Let-7 microRNA-mediated caspase-3 downregulation, thereby conferring paclitaxel resistance in TNBCs.
|
29416635 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
<i>In vitro</i> experiments revealed that MTDH could the inhibit cell growth and activate caspase-3/7 activity and apoptosis in the four HCC cell lines.
|
28469766 |
2017 |
|
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
<i>In vitro</i>, BYD inhibited cellular apoptosis and regulated the expressions of key apoptotic molecules, including reducing the expression of B cell lymphoma-2 (Bcl-2) associated X protein (Bax) and cleaved caspase-3 and -9.
|
29867551 |
2018 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
<i>In vivo</i>, the MI mice exhibited worse cardiac function by echocardiographic assessment and showed larger myocardial scarring by light microscopy, whereas aliskiren treatment reversed these effects, which were also associated with the changes in caspase-3 and Bcl-2 expression as well as in the number of apoptotic cells.
|
29184499 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>Solanum nigrum</i> polysaccharide inhibits tumor growth in H22-bearing mice through regulation of caspase-3 and bcl-2.
|
29578179 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
<sup>125</sup>I particles can inhibit the growth of HGC-27 gastric cancer cell transplants and promote the expression of Bax, caspase-3 and caspase-8 mRNA in the tumor tissue.
|
31612002 |
2019 |
|
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
(4) As2O3-induced apoptosis of immune organs involved in mitochondrial pathway (decrease of B-cell lymphoma-2 (Bcl-2) and increase of protein 53 (p53), Bcl-2 Associated X Protein (Bax), caspase-9, caspase-3) and death receptor pathway (increase of factor associated suicide (Fas) and caspase-8).
|
28454103 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
(p) ran in particular produced exciting results when coupled with a version of the caspase 3 exon to treat bladder cancer.
|
27140445 |
2016 |