|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overall, our study describes a novel mechanism demonstrating that Aβ sequesters caspase-3 activity via direct interaction and facilitates future therapeutic development in AD.
|
27227450 |
2016 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increased appoptosin and caspase-3-cleaved tau were also observed in brain samples of patients with Alzheimer's disease and frontotemporal dementia with tau inclusions.
|
26335643 |
2015 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings demonstrate that GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5LO further establishing this protein as an attractive and viable therapeutic target for Alzheimer's disease.
|
26076991 |
2015 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our data, by identifying caspase-3 as the endogenous modulator of GSAP and Aβ production, establish caspase-3 as a novel, attractive and viable Aβ-lowering therapeutic target for AD.
|
25052851 |
2015 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in vitro and in vivo studies report elevated expression and activation of CASP3 in models of AD.
|
24338704 |
2014 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: Implications for Alzheimer's disease.
|
25102327 |
2014 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
These included targeted delivery of anti-apoptotic protein humanin through the blood-brain barrier (BBB) to neuronal cells, specific inhibition of caspase-3 activation to inhibit the early triggering of AD progression, and delivery of humanin into the cytoplasm of neuronal cells undergoing apoptosis where it exerts its anti-apoptotic functions effectively.
|
23298615 |
2013 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistent with a potentially proapoptotic effect of PAR-4 and ceramide, astrocytes surrounding amyloid plaques in brain sections of the 5xFAD mouse (and Alzheimer disease patient brain) showed caspase 3 activation and were apoptotic when co-expressing PAR-4 and ceramide.
|
22532571 |
2012 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in vitro and in vivo studies reported elevated expression and activation of CASP3 in models of AD.
|
22307387 |
2012 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that Aβ42 may increase the BACE1 level independently of either Cdk5 or caspase 3 and that Cdk5 inhibition for AD may cause BACE1 elevation, a potentially negative therapeutic outcome.
|
22223639 |
2012 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Activated caspase-3 cleaves APP family proteins to release N-terminal fragments (NTFs) and intracellular C-terminal domains (ICDs), which can translocate into the nucleus and induce neurotoxicity in AD.
|
20732423 |
2011 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model.
|
20966551 |
2011 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
C/EBP homologous protein (CHOP), caspase-3, caspase-4, and caspase-12, downstream mediators of cell death pathway, were activated in AD.
|
20368688 |
2010 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
CTD_human |
The current investigation focused on detection of PtdSer on the outer leaflet of the bilayer in synaptosomes from brain of subjects with AD and amnestic mild cognitive impairment (MCI), as well as expression levels of apoptosis-related proteins Bcl-2, Bax, and caspase-3.
|
18077176 |
2008 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine a possible role for TDP-43 in Alzheimer's disease (AD), a site-directed caspase-cleavage antibody to TDP-43 based upon a known caspase-3 cleavage consensus site within TDP- 43 at position D219 was designed.
|
18634762 |
2008 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
LHGDN |
These data demonstrate for the first time the preferential localization and increase of caspase-3 in the PSD fractions in AD and suggest an important role for caspase 3 in synapse degeneration during disease progression.
|
18818379 |
2008 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The current investigation focused on detection of PtdSer on the outer leaflet of the bilayer in synaptosomes from brain of subjects with AD and amnestic mild cognitive impairment (MCI), as well as expression levels of apoptosis-related proteins Bcl-2, Bax, and caspase-3.
|
18077176 |
2008 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, a principal caspase pathway from caspase-8 to caspase-3 and/or 7 may contribute to neuron loss in AD brain.
|
16772874 |
2006 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Notably, we found a significant increase of apoptotic cells and caspase-3 activity in lymphocytes from AD patients bearing one or two alleles of the ApoE4 compared to non-E4 carriers.
|
16736246 |
2006 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cleavage of tau by caspase-3 was recently confirmed to occur in AD brain as an early event.
|
15750210 |
2005 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistent with the proposal that apoptosis plays a central role in human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and Alzheimer's disease.
|
15359610 |
2004 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition to finding reduced cytochrome oxidase activity, elevated ROS, and reduced ATP levels in the AD cybrids, when these cell lines were exposed to Abeta 1-40 we observed excessive mitochondrial membrane potential depolarization, increased cytoplasmic cytochrome c, and elevated caspase-3 activity.
|
15189344 |
2004 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain.
|
12070657 |
2002 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistent with the proposal that apoptosis plays a central in role human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and Alzheimer's disease.
|
10764048 |
2000 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In 9 cases of morphologically confirmed AD (CERAD criteria, Braak stages 5 or 6), 5 cases of Parkinson disease (PD) and 3 cases each of Dementia with Lewy bodies (DLB), Progressive Supranuclear Palsy (PSP), and Multiple System Atrophy (MSA), and 7 age-matched controls, the TUNEL method was used to detect DNA fragmentation, and immunohistochemistry for an array of apoptosis-related proteins (ARP), protooncogenes, and activated caspase-3 were performed.
|
10961423 |
2000 |