|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude global histone H4 acetylation is a prognostic marker and a potential therapeutic target in ALL.
|
26520622 |
2015 |
|
Acute monocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML.
|
26072331 |
2015 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that plasma histone H4 levels were greatly increased in patients with ACLF as compared with chronic hepatitis B, liver cirrhosis and healthy control subjects and were significantly associated with disease severity, systemic inflammation and outcome.
|
27660136 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude global histone H4 acetylation is a prognostic marker and a potential therapeutic target in ALL.
|
26520622 |
2015 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We show that both Myc and Omomyc stimulate histone H4 symmetric dimethylation of arginine (R) 3 (H4R3me2s), in human glioblastoma and HEK293T cells.
|
26563484 |
2015 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The expression of one of the nine mammalian PRMTs, PRMT5, affects the levels of symmetric dimethylarginine (SDMA) at Arg-3 on histone H4, leading to the repression of genes which are related to disease progression in lymphoma and leukemia.
|
28874563 |
2017 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A recurrent translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in fusion of BCL6 with a particular histone H4 gene on 6p21.
|
12414651 |
2002 |
|
Alveolitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation analysis showed that H4 deacetylation affected both alveolitis and pulmonary fibrosis.
|
28961490 |
2017 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to examine acetylation of histone H4 at lysine 12 (H4K12) in monocytes in two transgenic AD mouse models (the triple transgenic 3xTg and a model overexpressing amyloid-precursor protein APP with the Swedish-Dutch-Iowa mutations), and to compare with monocytes isolated from human patients with mild cognitive impairment (MCI) and AD.
|
26159193 |
2015 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we use mouse models of atherosclerosis-a major underlying cause of mortality worldwide-to demonstrate that extracellular histone H4-mediated membrane lysis of smooth muscle cells (SMCs) triggers arterial tissue damage and inflammation.
|
31043745 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, GR binding and histone H4 acetylation remained significantly lower in monocytes from patients with SR asthma.
|
24418482 |
2014 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We show here that the potent co-activating properties of HiNF-P/p220(NPAT) on the histone H4 gene promoter, which are evident in the majority of human cell types, are sporadically neutralized in distinct somatic cell lines.
|
17163457 |
2007 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we use mouse models of atherosclerosis-a major underlying cause of mortality worldwide-to demonstrate that extracellular histone H4-mediated membrane lysis of smooth muscle cells (SMCs) triggers arterial tissue damage and inflammation.
|
31043745 |
2019 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For the current study, we hypothesized that 3 of the genes in this region could be involved in the development of autism: 1) paired-like homeodomain transcription factor 1 (PITX1), which is a key regulator of hormones within the pituitary-hypothalamic axis, 2) neurogenin 1, a transcription factor involved in neurogenesis, and 3) histone family member Y (H2AFY), which is involved in X-chromosome inactivation in females and could explain the 4:1 male:female gender distortion present in autism.
|
18053270 |
2007 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition to previously identified acetylation of histone H4, H2A and H2B, this study shows that trimethylation of histone H3 on lysine 27 is induced by apoptosis and associated with autoimmunity in SLE.
|
20699234 |
2011 |
|
B-Cell Lymphomas
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.
|
12414651 |
2002 |
|
Benign Prostatic Hyperplasia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of HIST1H4K promoter hypermethylation significantly discriminated PC patients from YAM (AUC =0.763; 95% CI 0.672-0.839; p<0.0001), but did not show any statistical difference between PC patients and BPH controls (AUC=0.513, 95% CI 0.402-0.622; p=0.8255).
|
24065480 |
2014 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In total, we identify and quantify 233 proteoforms of histone H4 in two breast cancer cell lines.
|
29667342 |
2018 |
|
Breast Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A novel histone H4 variant H4G regulates rDNA transcription in breast cancer.
|
31219579 |
2019 |
|
Carcinogenesis
|
0.040 |
PosttranslationalModification
|
phenotype |
BEFREE |
The results suggest that the promoter hypermethylation of HIST1H4K is rather due to aging than related to prostate carcinogenesis.
|
24065480 |
2014 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
On the basis of these results, we propose that lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis.
|
24097061 |
2013 |
|
Carcinogenesis
|
0.040 |
PosttranslationalModification
|
phenotype |
BEFREE |
This review presents current evidence of the role of histone H4 lysine 20 methylation in normal and cancer cells and during tumorigenesis induced by genotoxic and nongenotoxic carcinogens.
|
22035019 |
2012 |
|
Carcinogenesis
|
0.040 |
PosttranslationalModification
|
phenotype |
BEFREE |
We investigated whether epigenetic changes of histone H4 are involved in lung carcinogenesis.
|
18974389 |
2008 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Quantitative real-time RT-PCR analysis showed that Mth1 mRNA expression was slightly, but significantly, increased in the primary carcinomas (P = 0.001 using GAPDH for normalization, and P = 0.002 using histone H4, t-test), contrary to our expectation, and was decreased to 1 / 2 in the cell lines.
|
12036445 |
2002 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings indicate that NatD is a crucial epigenetic modulator of cell invasion during lung cancer progression.NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth.
|
29030587 |
2017 |