|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A missense SNP in exon 10 of the CASP8 gene SNP D302H was associated with worse overall and event-free survival in patients with MYCN-amplified neuroblastoma tumors.
|
25502557 |
2014 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Contrarily, the presence of the -652 6N Del or the CASP8 302His variant was reported to be an unfavorable prognostic factor in colorectal cancer or neuroblastoma.
|
27507139 |
2016 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Caspase 8-null neuroblastoma cells were resistant to death receptor- and doxorubicin-mediated apoptosis, deficits that were corrected by programmed expression of the enzyme.
|
10802708 |
2000 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the IFN-gamma restoration of caspase 8 in some NB cells revealed persistent TRAIL resistance in most NB cell lines examined.
|
12615731 |
2003 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the methylation pattern of 14.3.3sigma, RASSF1A and of an intragenic segment of CASP8 was significantly different between MYCN amplified and single copy neuroblastoma suggesting a specific role of epigenetic alterations in aggressive neuroblastoma.
|
16044164 |
2005 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings define caspase-8 as a metastasis suppressor gene that, together with integrins, regulates the survival and invasive capacity of neuroblastoma cells.
|
16397500 |
2006 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8.
|
15033719 |
2003 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose the simultaneous analysis of hypermethylation of APAF1, TMS1 and CASP8 apoptotic genes on primary NB tumour as a good prognostic factor of disease progression.
|
21104989 |
2011 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The retinoic acid analogue 4HPR, IFN-gamma, and the demethylating agent 5-aza-cytidine activate this promoter in NB cells that lack endogenous caspase-8, indicating that this element may regulate both constitutive and inducible CASP8 expression.
|
15650242 |
2004 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Caspase-8 silenced N-type invasive NB cell lines LAN-1 and IMR-32 were investigated for their sensitivity to dox, and compared to S-type noninvasive SH-EP NB cells expressing caspase-8.
|
12203125 |
2002 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, gemcitabine-induced apoptosis was observed irrespective of the caspase-8 status of neuroblastoma cells, which indicates that apoptosis depends on the mitochondrial pathway.
|
15867251 |
2005 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CASP8 defects therefore represent an independent event in neuroblastoma, counteracting the N-myc induced susceptibility to apoptosis.
|
12880977 |
2003 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma.
|
17064406 |
2006 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic alterations have been described as well: caspase-8 (CASP8) and RAS-association domain family 1 isoform A (RASSF1A) DNA-methylation are important events for the development and progression of neuroblastoma.
|
21725203 |
2011 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
As frequent methylation of the CASP8 gene has also been reported in neuroblastoma, we investigated whether RASSF1A and CASP8 methylation were independent or related events.
|
11709729 |
2001 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
However, approximately 20% of the neuroblastoma cell lines with methylated CASP8 alleles are also highly resistant to staurosporine (STS)- and radiation-induced cell death, presumably because cytochrome c is not released from mitochondria.
|
11896617 |
2002 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequently others have also shown that caspase-8 is silenced by methylation in neuroblastoma and peripheral neural ectodermal tumors, and that the caspase-9 regulator Apaf-1 is silenced by methylation in melanoma cell lines and patient samples.
|
11511973 |
2001 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array.
|
19260109 |
2009 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a, p16INK4a, p14ARF, APC, RB1, RASSF1A, BLU, FHIT, RARbeta, INI1, TIMP3, NF2, MGMT, DAPK, FLIP, ECAD, CASP8, and the receptors DcR1 and DcR2).
|
17570703 |
2008 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A missense mutation was detected at codon 96, GCT (Alanine) to GTT (Valine), of the caspase 8 gene in one of the NB cell lines lacking caspase 8 expression.
|
11466626 |
2001 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The combined data suggest that FOXO3 is activated by 5-azadC treatment and triggers expression of caspase-8 in caspase-8-negative neuroblastoma, which may have important implication for metastasis, therapy, and death resistance of this childhood malignancy.
|
22493319 |
2012 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that four different retinoic acid (RA) derivatives also increase caspase-8 protein expression in neuroblastoma, medulloblastoma and small cell lung carcinoma cell lines.
|
18342014 |
2008 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
|
16886176 |
2006 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that Fas-mediated apoptosis in neuroblastoma cells is mitochondria-dependent and inhibited both at the mitochondrial level and at the level of caspase 8 activation.
|
11406564 |
2001 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subcellular fractionation analysis revealed caspase-8 activity in both cytosol and plasma membrane fractions in both NB7 reconstituted caspase-8 cell lines, as well the LNCaP prostate cancer cells.
|
23456622 |
2013 |