CUL4B, cullin 4B, 8450

N. diseases: 162; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4023721
Disease: Abnormal hair pattern
Abnormal hair pattern 		0.100 Biomarker disease HPO
CUI: C4021808
Disease: Abnormality of earlobe
Abnormality of earlobe 		0.100 Biomarker disease HPO
CUI: C4021745
Disease: Abnormality of the musculature
Abnormality of the musculature 		0.100 Biomarker phenotype HPO
CUI: C0857379
Disease: Abnormality of the pinna
Abnormality of the pinna 		0.100 Biomarker phenotype HPO
CUI: C1854882
Disease: Absent speech
Absent speech 		0.100 Biomarker phenotype HPO
CUI: C0000889
Disease: Acanthosis Nigricans
Acanthosis Nigricans 		0.100 Biomarker disease HPO
CUI: C0158465
Disease: Acquired cubitus valgus
Acquired cubitus valgus 		0.100 Biomarker disease HPO
CUI: C0234376
Disease: Action Tremor
Action Tremor 		0.010 Biomarker phenotype BEFREE We conclude that the CUL4B gene should be screened in males with severe speech impairment and primary intention tremor, especially if characteristic facial dysmorphism is also present. 20002452 2010
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 Biomarker disease BEFREE In contrast, knockdown of c-Myc, CUL4A or CUL4B in the colon adenocarcinoma cell line HT29 caused accumulation of ST7 and inhibition of cell proliferation, colony formation ability and in vivo tumour growth. 30945288 2019
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 AlteredExpression disease BEFREE NCBP1 promotes the development of lung adenocarcinoma through up-regulation of CUL4B. 31448526 2019
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma 		0.010 Biomarker disease BEFREE CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma. 30612524 2019
CUI: C0001807
Disease: Aggressive behavior
Aggressive behavior 		0.100 Biomarker phenotype HPO
CUI: C0554985
Disease: Aggressive outburst
Aggressive outburst 		0.010 GeneticVariation disease BEFREE Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. 17236139 2007
CUI: C0002902
Disease: Anencephaly
Anencephaly 		0.010 AlteredExpression disease BEFREE Notably, the expression of HOXA10 genes was negatively correlated with CUL4B levels in human anencephaly NTD cases. 30992047 2019
CUI: C0003864
Disease: Arthritis
Arthritis 		0.010 Biomarker disease BEFREE CUL4B promotes the pathology of adjuvant-induced arthritis in rats through the canonical Wnt signaling. 29626254 2018
CUI: C0004134
Disease: Ataxia
Ataxia 		0.010 GeneticVariation phenotype BEFREE Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxia. 20014135 2010
CUI: C1854418
Disease: Biparietal narrowing
Biparietal narrowing 		0.100 Biomarker phenotype HPO
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.010 AlteredExpression disease BEFREE Levels of CUL4B mRNA and protein were increased in BC tissues in comparison with the adjacent normal tissues. 29100384 2017
CUI: C0005744
Disease: Blepharophimosis
Blepharophimosis 		0.100 Biomarker disease HPO
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE While high mRNA expression of CUL2, CUL4B, and CUL5 were correlated with better survival for breast cancers.The associated results suggested that some Cullin members could serve as new predictive prognostic indicators for breast cancer. 31374029 2019
CUI: C0856863
Disease: Broad-based gait
Broad-based gait 		0.100 Biomarker phenotype HPO
CUI: C0240543
Disease: Bulbous nose
Bulbous nose 		0.100 Biomarker phenotype HPO
CUI: C0240635
Disease: Byzanthine arch palate
Byzanthine arch palate 		0.100 Biomarker disease HPO
CUI: C0006625
Disease: Cachexia
Cachexia 		0.100 Biomarker phenotype HPO
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE Our experiments unveiled a coordinated action between histone ubiquitination/methylation and DNA methylation in transcription repression, providing a mechanism for CUL4B in tumorigenesis. 24292684 2015