Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Induction of diabetes was associated with a marked reduction in glutathione (GSH) levels; decreased activities of GSH peroxidase (GSH Px), manganese superoxide dismutase (MnSOD) and catalase; increased reactive oxygen species (ROS) levels and iNOS activity in plasma and lymphoid organs.
|
28129627 |
2017 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Studies suggest that acatalasemic individuals (i.e., those with very low catalase activity) have a higher risk for the development of diabetes.
|
27939935 |
2017 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to examine association of decreased blood catalase activity and catalase exon mutations in patients (n=617) with diabetes (n=380), microcytic anemia (n=58), beta-thalassemia (n=43) and presbycusis (n=136) and in controls (n=295).
|
25772105 |
2015 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Rats were studied 30 days after the STZ treatment, and the diabetes untreated model group presented significantly higher kidney index, blood glucose, triglyceride (TG), total cholesterol (TC), malondialdehyde (MDA), interferon-γ (IFN-γ), and IFN-γ/IL-4 levels, lower body weight, fasting blood insulin (FPI), IL-4, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and nitric oxide (NO) levels and worse renal function (higher blood urea nitrogen (BUN), serum creatinine (SCr), urine protein (UP) levels and glomerular extracellular matrix (relative area)) compared with the normal control group (p < 0.05).
|
24595557 |
2014 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The high (18.5%) prevalence of diabetes mellitus in inherited catalase deficient individuals and the earlier (10 years) manifestation of the disease may be attributed to the oxidative damage of oxidant sensitive, insulin producing pancreatic beta-cells.
|
24025477 |
2014 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Decrease in Sirtuin1 (SIRT1) and nuclear factor erythroid 2-related factor (Nrf2) and increase in nuclear factor kappa B (NFκB) gene expression in diabetes were associated with a decrease in CAT and GPx mRNA expression.
|
24740756 |
2014 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catalase (CAT) is a major antioxidant enzyme and a number of polymorphisms in CAT have been shown to be associated with several diseases, including hypertension, diabetes mellitus, Alzheimer's disease, and vitiligo.
|
24817970 |
2014 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Whatever impaired glucose tolerance, insulin resistance on diabetes and whatever their occurrence or implications, the studies taken together converge toward the hypothesis that catalase polymorphisms play a role in glucose disorders.
|
22617568 |
2012 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Effects of rs769217 and rs1001179 polymorphisms of catalase gene on blood catalase, carbohydrate and lipid biomarkers in diabetes mellitus.
|
22712453 |
2012 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
(i) to determine the extent of oxidative stress and DNA damage and repair using a panel of selected markers in patients with type 1 and type 2 diabetes mellitus (T1DM, T2DM), (ii) to find their possible relationships with diabetes compensation and duration, and finally (iii) to test for the effect of functional polymorphisms in the 8-oxoguanin DNA glycosylase (rs1052133), catalase (rs1001179) and superoxide dismutase (rs4880) genes on respective intermediate phenotypes.
|
21338322 |
2011 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catalase (CAT) is a major antioxidant enzyme and a number of polymorphisms in the CAT have been described as being associated with several diseases, such as hypertension, diabetes mellitus, Alzheimer's disease, and vitiligo.
|
18353692 |
2008 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus.
|
18423055 |
2008 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.
|
17577741 |
2007 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.
|
17577741 |
2007 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Detection of a novel familial catalase mutation (Hungarian type D) and the possible risk of inherited catalase deficiency for diabetes mellitus.
|
15800961 |
2005 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Detection of a novel familial catalase mutation (Hungarian type D) and the possible risk of inherited catalase deficiency for diabetes mellitus.
|
15800961 |
2005 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catalase gene mutations have been detected in association with diabetes mellitus, hypertension, and vitiligo.
|
15771551 |
2004 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Hereditary catalase deficiencies and increased risk of diabetes.
|
11117918 |
2000 |