Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands.
|
19577318 |
2009 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
CTD_human |
Two SNPs, rs2346061 in CNDP1 and rs7577 in CNDP2, were associated with an increased risk of diabetic nephropathy (rs2346061 p = 5.07 × 10(-4); rs7577 p = 0.021).
|
21573905 |
2011 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CNDP1 polymorphism was not associated with mortality, and nor was there an interaction of this polymorphism with DN for prediction of mortality in patients with type 1 diabetes.
|
20711718 |
2010 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Protection from diabetic nephropathy afforded by 5L-5L homozygosity in CNDP1 may be masked by the effects of additional risk haplotypes in CNDP1 and CNDP2.
|
19373489 |
2009 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors conducted meta-analysis on association between the CNDP1 D18S880 microsatellite polymorphism and DN susceptibility, using fixed and random effects models.
|
23402577 |
2013 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data may further clarify the link among CNDP1 genotype, carnosinase, and diabetic nephropathy.
|
22496410 |
2012 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the association of polymorphisms within the CNDP1/CNDP 2 locus with diabetic nephropathy in Japanese subjects with type 2 diabetes.
|
23342076 |
2013 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes.
|
18753673 |
2008 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
CNDP1 and ELMO1 were examined along with eight other genes that are less well characterized for DN in a new study of Mexican-Americans.
|
20299368 |
2010 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, we identified an allelic variant of human carnosinase 1 (CN1) that results in increased enzyme activity and is associated with susceptibility for diabetic nephropathy in humans.
|
21833769 |
2012 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes.
|
18753673 |
2008 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
LHGDN |
This replicates the CNDP1 gene association with DN that was initially detected in European Caucasians and in Arabs, and further demonstrates that the CNDP1 gene and carnosine pathway appear to play a role in susceptibility to DN.
|
17205963 |
2007 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In view of a polymorphism in the carnosinase 1 gene CNDP1, resulting in reduced carnosine degradation activity and a significant DN risk reduction, carnosine (β-alanyl-L-histidine) has gained attention as a potential therapeutic target.
|
30914013 |
2019 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
CTD_human |
These complimentary approaches have demonstrated that polymorphisms in the carnosinase 1 gene on chromosome 18q, the adiponectin gene on 3q, and the engulfment and cell motility gene on 7p are likely associated with susceptibility to diabetic nephropathy.
|
17942768 |
2007 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease.
|
21393041 |
2011 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low serum carnosinase (CN-1) concentrations are associated with low risk for development of diabetic nephropathy (DN) in patients with type 2 diabetes (T2D).
|
29961141 |
2019 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for a 5-leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been associated with a reduced prevalence of diabetic nephropathy in cross-sectional studies in patients with type 2 diabetes, particularly in women.
|
24756973 |
2015 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These complimentary approaches have demonstrated that polymorphisms in the carnosinase 1 gene on chromosome 18q, the adiponectin gene on 3q, and the engulfment and cell motility gene on 7p are likely associated with susceptibility to diabetic nephropathy.
|
17942768 |
2007 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Carnosinase 1 (CN1) has been postulated to be a susceptibility factor for developing diabetic nephropathy (DN).
|
29922921 |
2019 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Because carnosine, the natural substrate for carnosinase, exerts antioxidative effects and inhibits ACE activity and advanced glycation end product formation, our results support the finding that diabetic patients homozygous for CNDP1 5L are protected against diabetic nephropathy.
|
17601991 |
2007 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
LHGDN |
L-carnosine, a substrate of carnosinase-1, influences glucose metabolism.
|
17601992 |
2007 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, we demonstrated that a polymorphism in exon 2 of the serum carnosinase (CNDP1) gene is associated with susceptibility to developing diabetic nephropathy.
|
17601991 |
2007 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs, rs2346061 in CNDP1 and rs7577 in CNDP2, were associated with an increased risk of diabetic nephropathy (rs2346061 p = 5.07 × 10(-4); rs7577 p = 0.021).
|
21573905 |
2011 |
Diabetic Nephropathy
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
|
16046297 |
2005 |
Diabetic Nephropathy
|
0.400 |
Biomarker
|
disease |
BEFREE |
Carnosinase 1 (CN1) contributes to diabetic nephropathy by cleaving histidine-dipeptides which scavenge reactive oxygen and carbonyl species and increase nitric oxide (NO) production.
|
26081982 |
2015 |