|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations.
|
29470556 |
2018 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These include: (1) the intra-renal renin-angiotensin system (RAS), one based on molecular variations in angiotensinogen; (2) the Na, K, 2Cl cotransporter (NKCC2) and its regulators in the thick ascending limb, which are associated with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks.
|
23397215 |
2013 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Some of the most striking findings relate to APOL1 genetic variants, seen exclusively in individuals of sub-Saharan African descent, that create a predisposition to particular renal disorders, including focal segmental glomerulosclerosis and arterionephrosclerosis.
|
30082052 |
2018 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Urinary JCPyV was associated with paradoxically lower rates of nephropathy in those with APOL1 high-risk genotypes.
|
30320619 |
2019 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we discuss the possibility that abnormal efflux of cellular potassium or other cations may be relevant to the pathogenesis of APOL1 nephropathy.
|
29110762 |
2017 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We sought to evaluate the cardiovascular impact of coding variants in the apolipoprotein L1 gene APOL1 that protect against trypanosome infection but have been associated with kidney disease among African Americans.
|
26634651 |
2016 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genome-wide association studies have identified a substantial signal at 22q13, now assigned to variation at apolipoprotein L1 (APOL1), which has associated with progressive nondiabetic nephropathy, cardiovascular disease, and many immune-associated renal diseases, including lupus nephritis.
|
28265848 |
2017 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
For example, the G1 and G2 variants of the APOL1 gene supporting control of Trypanosoma infection come with the trade-off that they promote the progression of kidney disease.
|
28481398 |
2017 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
MYH9 and APOL1 are both associated with sickle cell disease nephropathy.
|
21910715 |
2011 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Homozygosity for apolipoprotein-L1 (APOL1) risk variants has emerged as an important predictor of renal disease in individuals of African descent over the past several years.
|
27588375 |
2016 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene-gene interactions in APOL1-associated nephropathy.
|
24157943 |
2014 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This article reviews the current status of APOL1-associated nephropathy and discusses research questions under active investigation in the search for a cure for these severe and often progressive kidney diseases.
|
24119848 |
2013 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Since HIVAN has the strongest association with APOL1 genotype of any of the APOL1-associated nephropathies, studies to determine the mechanisms by which HIV and APOL1 risk variants together promote kidney injury hold great promise to improve our understanding of the pathogenesis of APOL1-mediated kidney diseases.
|
29930940 |
2018 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOL1 risk variants have been shown to be strongly associated with an increased risk for non-diabetic kidney disease including HIV nephropathy, primary non-monogenic focal and segmental glomerulosclerosis, and hypertension-attributed nephropathy among African ancestry populations in the USA.
|
23860441 |
2013 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We conclude that variation in APOL1 G3 makes a nominal, if any, contribution to ESRD in African Americans; G1 and G2 variants explain the vast majority of nondiabetic nephropathy susceptibility.
|
25249559 |
2015 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we examined the effects of overexpressing wild-type (G0) and kidney disease risk variants (G1 and G2) of APOL1 in human podocytes using a lentivirus expression system.
|
24899058 |
2014 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOL1 G1/G2 variants are the strongest genetic predictors of kidney disease in the general African-American population.
|
26206798 |
2015 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcript analysis of mouse kidney disease models, including folic-acid (FA)-induced nephropathy, unilateral ureteral obstruction (UUO), or apolipoprotein L1 (APOL1)-associated kidney disease, indicated that Jag1 and Notch2 levels were higher in all analyzed kidney fibrosis models.
|
30226866 |
2018 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Kidneys from African American deceased donors with two APOL1 nephropathy variants reproducibly associate with higher risk for allograft failure after transplantation.
|
25809272 |
2015 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study not only reveals the contribution of each domain of the APOL1 protein to cell injury, but also highlights some potential suggested targets for drug design to prevent or treat APOL1-associated nephropathy.
|
26091559 |
2015 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of APOL1 associations with kidney diseases and delineation of injury pathways brings hope for effective treatment for these kidney diseases.
|
30343724 |
2018 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOL1 genotypes are associated with kidney diseases in African American individuals and may influence cardiovascular disease and mortality risk, but findings have been inconsistent.
|
29971324 |
2018 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In populations of African ancestry, two <i>apolipoprotein-L1 (APOL1</i>) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency.
|
28537557 |
2017 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Heterogeneity in study population and study design has led to differing reports on the role of APOL1 nephropathy risk variants in CVD.
|
31082862 |
2019 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The linkage peak on chromosome 22q overlaps the MYH9/APOL1 gene region, previously implicated in AA diabetic and nondiabetic nephropathies.
|
21454968 |
2011 |