|
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
Five-point check-list: 1) visible sun damaged skin on exposed areas (red and brown to black macules and crusts on visible skin); 2) more than 20 nevi on the arms; 3) one or more ABCD positive lesions (flat, large and asymmetric macules); 4) one or more EFG positive lesions (elevated, firm and growing skin lesions); 5) a pigmented lesion larger than 1.5 cm in diameter.
|
28209049 |
2019 |
|
Cataract, Congenital, Cerulean Type, 2
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative gene expression levels of EFG1, UME6, HGC1 and ECE1 were all downregulated after CUR-PDT, with fold-decrease of 6.865, 3.382, 2.167 and 6.887 in ATCC 90028, 2.466, 2.146, 1.627 and 3.102 in CCA1, and 5.406, 2.347, 2.073and 3.711 in CCA2 (p < 0.05).
|
31233886 |
2019 |
|
Carcinoma, Papillary
|
0.010 |
Biomarker
|
disease |
BEFREE |
- To detect histologic and molecular differences separating NIFTP from follicular adenomas (FAs) and invasive carcinomas, particularly papillary carcinomas with extensive follicular growth (PTC-EFGs) and invasive encapsulated PTC-FV (IE-PTC-FV).
|
29582677 |
2018 |
|
Follicular adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
- To detect histologic and molecular differences separating NIFTP from follicular adenomas (FAs) and invasive carcinomas, particularly papillary carcinomas with extensive follicular growth (PTC-EFGs) and invasive encapsulated PTC-FV (IE-PTC-FV).
|
29582677 |
2018 |
|
Follicular neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
- The morphologic similarity and RAS mutations in FAs, NIFTPs, and IE-PTC-FVs supports the genetic similarity of those follicular neoplasms in contrast to the unique presence of BRAF V600E mutations in PTC-EFGs.
|
29582677 |
2018 |
|
Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features
|
0.010 |
Biomarker
|
disease |
BEFREE |
- To detect histologic and molecular differences separating NIFTP from follicular adenomas (FAs) and invasive carcinomas, particularly papillary carcinomas with extensive follicular growth (PTC-EFGs) and invasive encapsulated PTC-FV (IE-PTC-FV).
|
29582677 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of <i>EGFR<sup>T790M</sup></i>.
|
28668882 |
2017 |
|
Congenital Disorders of Glycosylation
|
0.010 |
GeneticVariation
|
group |
BEFREE |
While exome sequencing was negative for CDG related candidate genes, the testing revealed compound heterozygous mutations in the mitochondrial elongation factor G gene (GFM1).
|
28216230 |
2017 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of <i>EGFR<sup>T790M</sup></i>.
|
28668882 |
2017 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of <i>EGFR<sup>T790M</sup></i>.
|
28668882 |
2017 |
|
Stomatitis, Denture
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using an established model of DS in immunocompetent animals, the purpose of this study was to determine the role of biofilm formation in mucosal damage during pathogenesis using C. albicans or mutants defective in morphogenesis (efg1-/-) or biofilm formation (bcr1-/-).
|
27453977 |
2016 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The short isoform of CD97, known as EGF(1,2,5), has been shown to promote invasion and metastasis, but its role in gliomas and GBM-derived brain tumor initiating cells (BTICs) has not been studied.
|
25714433 |
2015 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The short isoform of CD97, known as EGF(1,2,5), has been shown to promote invasion and metastasis, but its role in gliomas and GBM-derived brain tumor initiating cells (BTICs) has not been studied.
|
25714433 |
2015 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
The short isoform of CD97, known as EGF(1,2,5), has been shown to promote invasion and metastasis, but its role in gliomas and GBM-derived brain tumor initiating cells (BTICs) has not been studied.
|
25714433 |
2015 |
|
Endometriosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first study correlating the EFG +61 G/A polymorphism and endometriosis in women from Brazil, and demonstrates that EFG +61 G/A is not associated with endometriosis susceptibility in Brazilian women.
|
25222228 |
2014 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The development and metastasis of cervical carcinoma are closely related to epidermal growth factor (EGF) and EGF-1 receptor (EGFR).
|
24567178 |
2014 |
|
Biliary Tract Cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eight loci were identified for Gab1 (4), EGFR (3), and EGF (1) as the target single-nucleotide polymorphisms (SNPs) for the association of gene polymorphisms and BTC.
|
25217982 |
2014 |
|
Liver Failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report two novel GFM1 mutations in two unrelated patients with encephalopathy and liver failure respectively.
|
21986555 |
2012 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
Biomarker
|
group |
BEFREE |
Before the approval of hypomethylating agents in this indication, the GFM conducted a multicenter phase II trial testing the efficacy and tolerance of bevacizumab, a humanized monoclonal antibody against VEGF, in MDS with excess of marrow blasts and its impact on bone marrow angiogenesis.
|
21553011 |
2012 |
|
Mitochondrial Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The OXPHOS system defects and the impairment in mitochondrial translation in fibroblasts were rescued by overexpressing wild-type GFM1, establishing the GFM1 defect as the cause of the fatal mitochondrial disease.
|
21119709 |
2011 |
|
Myelodysplastic Syndrome with Isolated del(5q)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Treatment by Lenalidomide in lower risk myelodysplastic syndrome with 5q deletion--the GFM experience.
|
21715006 |
2011 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis.
|
20124286 |
2010 |
|
Polymicrogyria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The EFG1-mutant patient had early-onset Leigh syndrome, whereas the EFTu-mutant patient had severe infantile macrocystic leukodystrophy with micropolygyria.
|
17160893 |
2007 |
|
Liver diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Here we have investigated the molecular basis for tissue specificity in patients with a fatal hepatopathy due to mutations in the mitochondrial translation elongation factor EFG1.
|
16632485 |
2006 |
|
Adenovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We used non-invasive optical imaging of firefly luciferase to repeatedly monitor, in living animals, the ability of sCAR-EGF (i) to "transductionally untarget" systemically administered Ad.CMVfLuc, an adenovirus that constitutively expresses luciferase, from normal tissues and (ii) to "transductionally redirect" adenovirus infection in mice to xenograft tumors that express elevated epidermal growth factor (EGF) receptor levels.
|
15564150 |
2005 |