Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Atopic dermatitis (AD) is a common skin inflammatory disease characterized by the production of thymic stromal lymphopoietin (TSLP) and marked T<sub>H</sub> 2 polarization.
|
28191908 |
2017 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Atopic dermatitis (AD) is known to aggravate by thymic stromal lymphopoietin (TSLP) and TSLP is also known to up-regulate mast cell proliferation via production of interleukin (IL)-13.
|
28219709 |
2017 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis.
|
12055625 |
2002 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) produced by keratinocytes has recently been a focus in atopic dermatitis.
|
19609063 |
2009 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) plays a pivotal role in allergic diseases such as atopic dermatitis, asthma, and chronic obstructive pulmonary disease.
|
21856447 |
2011 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) may have a key role in the initiation and maintenance of allergic inflammatory diseases, including atopic dermatitis.
|
23639975 |
2013 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TSLP expression is enhanced in lesions with atopic dermatitis, and is a therapeutic target.
|
23688403 |
2013 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis and eosinophilic esophagitis.
|
25340427 |
2014 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP), which has been studied in various allergic diseases such as asthma, atopic dermatitis (AD) and eosinophilic esophagitis (EoE), has been less considered to be involved in IBDs.
|
27697608 |
2017 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, such as atopic dermatitis and psoriasis.
|
29279286 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TSLP is highly expressed in keratinocytes under inflammatory conditions, which suggests that it may play a critical role in the development of skin diseases, such as atopic dermatitis.
|
29310423 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) plays an important role in the initiation and progress of skin inflammation and atopic dermatitis by triggering Th2 immune responses.
|
29462589 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSLP has been originally implicated in a variety of allergic diseases (e.g., atopic dermatitis, bronchial asthma, eosinophilic esophagitis).
|
30057581 |
2018 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thymic stromal lymphopoietin (TSLP) plays an important role in allergic disorders, including atopic dermatitis and asthma.
|
30976816 |
2019 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TSLP variation was determined using targeted massively parallel sequencing in a longitudinal cohort of children with AD.
|
31491540 |
2019 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also, TSLP polymorphisms are associated with susceptibility to asthma, atopic dermatitis, and eczema herpeticum.
|
22948028 |
2013 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study.
|
25700684 |
2015 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of Filaggrin Loss of Function and Thymic Stromal Lymphopoietin Variation With Treatment Use in Pediatric Atopic Dermatitis.
|
27902816 |
2017 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
AST2017-01 and chrysophanol significantly suppressed the levels of histamine, immunoglobulin E, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4, IL-6, and tumor necrosis factor-α in serum of AD mice.
|
30025384 |
2018 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD1a expression is up-regulated by TSLP (thymic stromal lymphopoietin) at levels observed in the skin of patients with atopic dermatitis, and the response is dependent on PLA2G4A.
|
29273672 |
2017 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response.
|
17242164 |
2007 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Dermal transgenic expression of IL-13 causes an AD-like phenotype with fibrosis and increased TSLP.
|
21576506 |
2011 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA demethylation of a specific regulatory region of the TSLP gene may contribute to TSLP overexpression in skin lesions in patients with AD.
|
24341479 |
2014 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy.
|
28658558 |
2017 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), IL-1β, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model.
|
29353040 |
2018 |