Osteoporosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Four of these candidate variants (one each in CXXC1 and RUNX2 and two in LRP5) had a >70% derived allele frequency in East Asians, but were present at lower (20-60%) frequency in Europeans as well, suggesting that the adaptation might have been part of a common response to climatic and dietary changes as humans expanded out of Africa, with implications for their role in vitamin D-dependent bone mineralization and osteoporosis insurgence.
|
26719974 |
2015 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, our results show that circulating miR-19b plays an important role in enhancing osteoblastogenesis, possibly through regulation of the PTEN/pAKT/Runx2 pathway, and may be a useful therapeutic target in bone loss disorders, such as osteoporosis.
|
31614022 |
2020 |
Osteoporosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The A allele was associated with increased BMD and was protective against a common form of osteoporotic fracture, suggesting that RUNX2 variants may be related to genetic effects on BMD and osteoporosis.
|
12162506 |
2002 |
Osteoporosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of GAS5 promotes osteogenic differentiation of hMSCs through regulating microRNA-498 to up-regulate RUNX2 expression, thus alleviating the development of osteoporosis.
|
31599401 |
2019 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, MSC-based therapy for osteoporosis in CCD patients is difficult due to a reduction in the ability of MSCs to differentiate into osteoblasts resulting from impaired RUNX2 function.
|
29357927 |
2018 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
There were abnormal changes in the protein expressions of Bmp-2, Smad1, Smad5 and Runx2 in bone tissue, which may be an important mechanism underlying the development of kidney deficiency osteoporosis.
|
31304902 |
2019 |
Osteoporosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
All of the above indicate that oral administration of icariin can prevent diabetic osteoporosis; the effect is mainly related to its ability to reduce blood glucose, inhibit bone turnover and bone marrow adipogenesis, as well as up-regulate bone RUNX 2, and OPG expression.
|
31096652 |
2019 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that miR-135a-5p may serve a role in osteoporosis progression by regulating osteogenic differentiation via RUNX2.
|
31555350 |
2019 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Oxidative stress is implicated in osteoporosis; furthermore the osteoblast transcriptional factor RUNX2 is reported to play a protective role against osteoporosis in postmenopausal women.
|
19017541 |
2009 |
Osteoporosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that Runx2 expression in osteoblasts is reduced by hypoxia, and may be a mechanism of osteoporosis by decreased vascular supply.
|
12088880 |
2002 |
Osteoporosis
|
0.200 |
AlteredExpression
|
disease |
LHGDN |
These data indicate that Runx2 expression in osteoblasts is reduced by hypoxia, and may be a mechanism of osteoporosis by decreased vascular supply.
|
12088880 |
2002 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Plausibly, homeostatic feedback loops that rely on Runx2 activation to compensate for bone loss in GIO are thwarted, exacerbating disease progression through stimulation of Wif1..
|
27061521 |
2017 |
Osteoporosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
OP patients presented a higher serum level of miRNA-217 and lower serum levels of circ-VANGL1 and RUNX2 relative to non-OP patients.
|
30779060 |
2019 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Chromatin immunoprecipitation showed that higher methylation was associated with reduced SP7, RUNX2, and ERα binding to the <i>SOST</i> promoter in patients with osteoporosis.
|
30257098 |
2019 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thus, RUNX2 is a good candidate for the genetic determination of osteoporosis.
|
17878995 |
2007 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
LncRNA XIXT upregulated RUNX2 by absorbing miRNA-30a-5p, and thus induced hBMSCs osteogenesis to alleviate osteoporosis.
|
31696458 |
2019 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Regulation of bone formation by RUNX2 and PPARγ2 is modified in OA compared to OP, resulting in higher osteoblastogenesis and adipogenesis in OA.
|
21854818 |
2011 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
MiRNA-365a-3p negatively regulates osteogenic differentiation of hBMSCs by targeting RUNX2, thus promoting the progression of osteoporosis.
|
31599402 |
2019 |
Osteoporosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, caudal vein injection of agomir-23b notably caused severe osteoporosis in mice, and forced expression of runx2 by combined injecting Ad-runx2 attenuated the bone loss induced by miR-23b.
|
29234953 |
2018 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
Osteoporosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data implied that miR-221 played an important part in osteoporosis through regulating RUNX2 expression and osteoblast differentiation.
|
28123639 |
2017 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Cbfa-1 (Runx-2) and osteocalcin expression by human osteoblasts in heparin osteoporosis in vitro.
|
17000892 |
2006 |
Osteoporosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal dysplasia caused by heterozygous mutations of the runt-related transcription factor 2 (RUNX2) and significantly increases the risk of osteoporosis.
|
30506733 |
2019 |
Osteoporosis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The A allele was associated with increased BMD and was protective against a common form of osteoporotic fracture, suggesting that RUNX2 variants may be related to genetic effects on BMD and osteoporosis.
|
12162506 |
2002 |
Osteoporosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present results suggested that miR‑488 is a negative regulator of psoralen‑induced BMSC osteogenic differentiation by targeting Runx2, providing a possible therapeutic target for osteoporosis.
|
31485621 |
2019 |