|
Acute leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that ERK is constitutively activated in a majority of acute leukemias, and in addition to the activation of MEK, the hyperexpression of ERK and downregulation of PAC1 also contribute to constitutive ERK activation in acute leukemias.
|
10339498 |
1999 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In congruence with previous work, the PAC1 receptor internalization and endosomal MEK/ERK signaling appear contributory mechanisms to the addiction processes.
|
30074172 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Staining intensity of PAC1 receptor was strong in normal tissues both in the exocrine and endocrine parts of the pancreas, the receptor staining was markedly weaker in the adenocarcinoma.
|
31788045 |
2019 |
|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data functionally define a novel genetic locus, designated PAC1, for prostate adenocarcinoma 1, involved in tumor suppression of human prostate carcinoma and furthermore strongly suggest that the cell death pathway can be functionally restored in prostatic adenocarcinoma.
|
8637912 |
1996 |
|
Adult Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, PAC-1 was probably known to be associated with Burkitt Lymphoma (Odds Ratio [OR] 6.67, Relative Risk [RR] 3.13, 95% CI 1.06-9.21; p = 0.02).
|
31326577 |
2019 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Real-time polymerase chain reaction (PCR) was used to examine the effects of haloperidol, olanzapine and amisulpride on the expression of genes coding PAC1/VPAC type receptors in the T98G glioblastoma cell line, as an example of an in vitro model of glial cells.
|
27900577 |
2017 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Synergistic activity of PAC-1/TMZ in rodent models and the demonstration of feasibility of the combined regime in canine patients suggest potential for PAC-1 in the treatment of glioblastoma.
|
29113289 |
2017 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, procaspase-3 expressing glioma and meningioma cell lines were sensitive to the apoptotic effects of PAC-1 at biologically relevant exposures achievable in cancer patients.
|
30859090 |
2019 |
|
Ankylosing spondylitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The findings was consistent with previous genetic and functional studies that point at variants of the BRWD1 and/or PSMG1 loci as interesting genetic factors contributing to AS.
|
24643394 |
2014 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
The pituitary adenylate cyclase-activating peptide (PACAP) and its receptor (PAC1) are involved in stress response and anxiety.
|
23972788 |
2013 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The pituitary adenylate cyclase-activating peptide (PACAP) and its receptor (PAC1) are involved in stress response and anxiety.
|
23972788 |
2013 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Digoxin (2.4 ng/mL) induced calcium mobilization, PAC -1 (procaspase-activating compound 1) and platelet aggregation in AF patients but not in healthy subjects .
|
30571484 |
2018 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.
|
26658105 |
2016 |
|
Benign Prostatic Hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Type I PACAP receptors (PAC1 R) in healthy and BPH tissues were localized in all epithelial cells lining the lumen of the acini and in some stromal cells, while in specimens from PCa the anti-PAC1 R antibody stained the apical portion of a large percentage of cells.
|
16888207 |
2006 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of the PACAP-PAC1-DISC1 and PACAP-PAC1-stathmin1 systems in schizophrenia and bipolar disorder: novel treatment mechanisms?
|
19958095 |
2009 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Brain Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
While preliminary evidence supports procaspase-3 as a viable target in preclinical models, with PAC-1 demonstrating activity in rodent models and dogs with spontaneous brain tumors, the broader applicability of procaspase-3 as a target in human brain cancers, as well as the comparability of procaspase-3 expressions between differing species, requires further investigation.
|
30859090 |
2019 |
|
Brain Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
To determine the role of PACAP and PAC1-R expression on glial proliferation, two in vivo models were examined--human brain tumors of glial origin and the reactive gliosis induced by a penetrating stab wound to the mature rat brain.
|
10867818 |
2000 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PAC1 has been shown previously to be expressed and regulate the growth and proliferation of nonsquamous cell lung cancer cells, as well as breast cancer cell lines.
|
14742913 |
2004 |
|
Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, PAC-1 was probably known to be associated with Burkitt Lymphoma (Odds Ratio [OR] 6.67, Relative Risk [RR] 3.13, 95% CI 1.06-9.21; p = 0.02).
|
31326577 |
2019 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that PAC(1) and VPAC(1) receptors regulate VEGF expression in lung cancer cells.
|
12409225 |
2002 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Although mRNA for VPAC2-R is not common, VPAC1-R and PAC1-R mRNA is present in many lung cancer cell lines.
|
11193832 |
2000 |
|
Carcinoma, Pancreatic Ductal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PACAP and PAC1 receptor expression in pancreatic ductal carcinoma.
|
31788045 |
2019 |
|
Carcinoma, Papillary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PACAP and PAC1 receptor expressions were investigated from thyroid gland samples of patients with papillary carcinomas.
|
27566169 |
2016 |
|
Carotid Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results confirm positive correlations between total pMV number, the number of PAC-1+/CD61+ and CD62+/CD61+ MVs and carotid atherosclerosis in stroke subjects.
|
30763823 |
2019 |