CCK, cholecystokinin, 885

N. diseases: 326; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.070 AlteredExpression disease BEFREE In contrast, the cholecystokinin (CCK) gene which is widely present in nervous and endocrine systems was abundantly expressed in the human primitive neuroepithelioma cell line SK-N-MC and its clonal derivative SK-N-MC-IX-C. 1320892 1992
CUI: C4048305
Disease: Neuroepithelioma
Neuroepithelioma 		0.070 AlteredExpression disease BEFREE In contrast, the cholecystokinin (CCK) gene which is widely present in nervous and endocrine systems was abundantly expressed in the human primitive neuroepithelioma cell line SK-N-MC and its clonal derivative SK-N-MC-IX-C. 1320892 1992
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.040 AlteredExpression disease BEFREE Modulation of cholecystokinin (CCK) gene-expression in a human neuroblastoma cell line: effects of serum on enhanced CCK and c-fos mRNA expression. 1360635 1992
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 AlteredExpression disease BEFREE Modulation of cholecystokinin (CCK) gene-expression in a human neuroblastoma cell line: effects of serum on enhanced CCK and c-fos mRNA expression. 1360635 1992
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.040 AlteredExpression disease BEFREE Modulation of cholecystokinin (CCK) gene-expression in a human neuroblastoma cell line: effects of serum on enhanced CCK and c-fos mRNA expression. 1360635 1992
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Finally, our results suggest that CCK gene expression may serve as a marker to distinguish these tumors, which are considered to be small-round-cell tumors of childhood, from other pediatric tumors. 1631063 1992
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.070 Biomarker disease BEFREE However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. 1631063 1992
CUI: C4048305
Disease: Neuroepithelioma
Neuroepithelioma 		0.070 Biomarker disease BEFREE However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. 1631063 1992
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.040 Biomarker disease BEFREE However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. 1631063 1992
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.020 Biomarker disease BEFREE However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. 1631063 1992
CUI: C0220611
Disease: Childhood Rhabdomyosarcoma
Childhood Rhabdomyosarcoma 		0.020 Biomarker disease BEFREE However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. 1631063 1992
CUI: C0279550
Disease: Adult Rhabdomyosarcoma
Adult Rhabdomyosarcoma 		0.020 Biomarker disease BEFREE However, we have used a radioimmunoassay that detects the CCK precursor to demonstrate synthesis of CCK precursor-like peptides by all of the Ewing sarcoma and neuroepithelioma lines that were tested and by the rhabdomyosarcoma cell line that expresses CCK mRNA. 1631063 1992
CUI: C0242216
Disease: Biliary calculi
Biliary calculi 		0.310 Biomarker phenotype CTD_human Assessment of gall bladder dynamics, cholecystokinin release and the development of gallstones during octreotide therapy for acromegaly. 1631261 1992
CUI: C0009438
Disease: Common Bile Duct Calculi
Common Bile Duct Calculi 		0.300 Biomarker phenotype CTD_human Assessment of gall bladder dynamics, cholecystokinin release and the development of gallstones during octreotide therapy for acromegaly. 1631261 1992
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.050 Biomarker group BEFREE The cell line will be useful in further studies on the mechanism(s) by which CCK stimulates growth of certain human pancreatic adenocarcinomas and normal human pancreatic exocrine tissue. 1688394 1990
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.040 AlteredExpression disease BEFREE Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line. 1720402 1991
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 AlteredExpression disease BEFREE Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line. 1720402 1991
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.040 AlteredExpression disease BEFREE Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line. 1720402 1991
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.070 AlteredExpression disease BEFREE The human small-cell lung carcinoma line (SCLC) U-1690 expressed moderate levels of CCK mRNA as compared to the human neuroepithelioma cell line SK-N-MC. 1977617 1990
CUI: C4048305
Disease: Neuroepithelioma
Neuroepithelioma 		0.070 AlteredExpression disease BEFREE The human small-cell lung carcinoma line (SCLC) U-1690 expressed moderate levels of CCK mRNA as compared to the human neuroepithelioma cell line SK-N-MC. 1977617 1990
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.040 AlteredExpression disease BEFREE Thus, the human small cell carcinoma cell line U-1690 is a useful model for studies of cell-specific CCK gene expression. 1977617 1990
CUI: C0262584
Disease: Carcinoma, Small Cell
Carcinoma, Small Cell 		0.010 AlteredExpression disease BEFREE Thus, the human small cell carcinoma cell line U-1690 is a useful model for studies of cell-specific CCK gene expression. 1977617 1990
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.010 Biomarker disease BEFREE The cholecystokinin (CCK) content of temporal cortex, obtained at neurosurgery from 22 patients with temporal lobe epilepsy, was measured by a specific radioimmunoassay. 2060503 1991
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.010 AlteredExpression group BEFREE In addition, the -119 to -81 fragment of the CCK promoter contains a transcriptional enhancer that potentiates the transcription from the herpes simplex virus thymidine kinase promoter in a position- and orientation-independent manner. 2118525 1990
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.100 Biomarker disease BEFREE The effect of a synthetic analogue of CCK (Thr4,Nle7CCK-9) on growth of SW-1990 human pancreatic cancer was examined in two experimental models. 2226098 1990