|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The effects of recombinant Wnt3A protein on the in vitro growth of four acute myeloid leukemia (AML) and four acute T-lymphoblastic leukemia (T-ALL) cell lines was examined.
|
19035298 |
2008 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Wnt3A activates canonical Wnt signalling in acute lymphoblastic leukaemia (ALL) cells and inhibits the proliferation of B-ALL cell lines.
|
17156404 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Besides, high Wnt3a level predicted poorer lung adenocarcinoma survival by univariate Cox analysis (<i>P</i>=0.001), while the multivariate result was not significant (<i>P</i>=0.355).
|
28900490 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a.
|
27806326 |
2016 |
|
Adenocarcinoma of rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TIPE2 overexpression increased apoptosis through down-regulating the expression levels of Wnt3a, phospho (p)-β-Catenin, and p-glycogen synthase kinase-3β in rectal adenocarcinoma cells, however, TIPE2 knockdown exhibited reverse trends.
|
30637920 |
2019 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, PRC1 interacts with the β-catenin destruction complex, regulates Wnt3a-induced membrane sequestration of this destruction complex, inhibits adenomatous polyposis coli (APC) stability and promotes β-catenin release from the APC complex.
|
26941395 |
2016 |
|
Adult Glioblastoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We first demonstrated the non-specific interaction of Wnt3a and Wnt5a with the receptors LRP6 and ROR2 and the up-regulation of the Wnt pathway in glioblastoma cells.
|
25301448 |
2015 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In vivo, tumors formed from Wnt3a-stimulated glioblastoma cells presented greater microglial infiltration and more aggressive characteristics such as growth rate than untreated tumors.
|
29948952 |
2019 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the mRNA and protein expression levels of NTSR1 were increased by the Wnt pathway activator Wnt3a and decreased by the Wnt inhibitor iCRT3 in glioblastoma cells.
|
29065410 |
2017 |
|
Adult Glioblastoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma.
|
23337036 |
2013 |
|
Adult Glioblastoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We found that Wnt3a and ABCB1, which encodes for Pgp, were both highly expressed in glioblastoma stem cells and reduced by temozolomide.
|
23897632 |
2013 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wnt3a knockdown was used to determine the function of Wnt3a in liver cancer cell proliferation.
|
28901526 |
2017 |
|
Alzheimer's Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this study, we provide evidence that rapamycin inhibits GSK3β activation and elevates β‑catenin expression by improving the Wnt3a expression levels, which facilitates the amelioration of AD pathology.
|
31115485 |
2019 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
The SAMP8 mice received glutamine intragastrically for 8 consecutive weeks to evaluate the protective effect of glutamine on oxidative stress in AD mice involving Wnt3a/<i>β</i>-catenin signaling pathway.
|
31119171 |
2019 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
The Wnt signaling activated through the ligand Wnt3a has been described as a neuroprotective signaling pathway against amyloid-β (Aβ) peptide toxicity in AD.
|
28060833 |
2017 |
|
Alzheimer's Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Finally, using a bed nucleus of stria terminalis (BNST) mRNA expression array, we found that the expression of the 5-HT1A receptor in 3xTgAD mice is selectively decreased and normalized by Wnt3a overexpression in the ventral hippocampus DG, and this normalization is neurogenesis dependent.
|
24388979 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that the mRNA and protein of Wnt3a and Cyclin D1 in the spinal cord of the ALS mice were upregulated compared to those in wild-type mice.
|
22426476 |
2012 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
We examined if mature adipocytes can also be target cells and found that canonical Wnt activation by Wnt3a induced a marked dedifferentiation of both 3T3-L1 and human adipocytes.
|
20179324 |
2010 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Differentiating 3T3-L1 fibroblasts into mature adipocytes produced striking increases in P2 gene-products and dramatic falls in P1-transcribed mRNA, whereas Wnt3a-induced dedifferentiation of mature adipocytes produced reciprocal changes in P1 and P2 transcript levels.
|
25024173 |
2014 |
|
Anorectal Malformations
|
0.020 |
Biomarker
|
group |
BEFREE |
These data revealed that the expression of Wnt3a in ARM embryos was notably reduced, indicating a potential role for Wnt3a in the maldevelopment of the SMC in patients with ARMs.
|
28260053 |
2017 |
|
Anorectal Malformations
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The quantitative reverse transcription polymerase chain reaction (qRT-PCR) results showed that the expression of miR-342-5p was significantly increased in ARM anorectal tissues compared with normal tissues on GD19 and GD21, and the expression of Wnt3a demonstrated the opposite on GD21.
|
31074015 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
WISP-2 was upregulated in human atherosclerosis and partly co-localized with Wnt3a.
|
30548452 |
2019 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The activation of effector T cells increased Wnt3a production, and Wnt3a levels were found to be greatly increased in mononuclear cells isolated from synovial fluid versus peripheral blood of arthritis patients.
|
23954131 |
2013 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
WISP-2 was upregulated in human atherosclerosis and partly co-localized with Wnt3a.
|
30548452 |
2019 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results provide a new evidence that miR-27b-3p regulates the signaling pathway of Wnt/<i>β</i>-Catenin by targeting Wnt3a, which may play an important role in the development of atrial fibrosis and AF.
|
31178968 |
2019 |