|
Adenocarcinoma
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Bisulphite-treated DNA isolated from formalin-fixed and paraffin-embedded samples of 202 gastric adenocarcinomas and 22 normal gastric mucosae was subjected to real-time methylation-specific PCR (Q-MSP).
|
19002170 |
2008 |
|
Adult Glioblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma.
|
28967952 |
2017 |
|
African Burkitt's lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-MSP-1IgG3 and anti-6NANPIgG3 were indeterminate. eBL risk was potentially 21 times higher (95% CI 5.8-74) in HRP-IIIgG3-seropositive and SE36IgG1-seronegative responders compared with HRP-IIIgG3-seronegative and SE36IgG1-seropositive responders.
|
23645841 |
2013 |
|
Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rescued Tg(INV-<i>Cst6</i>)<i>Cst6<sup>ichq/ichq</sup></i> mice survive the neonatal phase, but display severe eye pathology and alopecia after 4 mo.
|
28596234 |
2017 |
|
Alpha trait thalassemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
A longitudinal study was conducted in a low endemic area in northern Tanzania to examine the influence of the α-thalassaemia trait on malaria incidence and antibody responses to malaria apical membrane antigen-1 (AMA-1) and merozoite surface protein1-19 (MSP-119).
|
25604491 |
2015 |
|
alpha-Thalassemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to parasite free individuals, individuals carrying sub-microscopic densities of P. falciparum parasites had significantly higher median antibody levels to MSP-1 (p = 0.042) and MSP-2 (p = 0.034) but not to AMA-1 (p = 0.14) while no clear relation between sub-microscopic parasite carriage and G6PD deficiency or alpha+-thalassaemia was observed.
|
19460160 |
2009 |
|
alpha^+^ Thalassemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to parasite free individuals, individuals carrying sub-microscopic densities of P. falciparum parasites had significantly higher median antibody levels to MSP-1 (p = 0.042) and MSP-2 (p = 0.034) but not to AMA-1 (p = 0.14) while no clear relation between sub-microscopic parasite carriage and G6PD deficiency or alpha+-thalassaemia was observed.
|
19460160 |
2009 |
|
American cutaneous leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results support the view that recombinant BCG expressing gp63 may prove a useful vaccine for inducing protective cell-mediated immune responses to Leishmania species causing American cutaneous leishmaniasis.
|
8265576 |
1993 |
|
Amyotrophic Lateral Sclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis.
|
20377183 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations.
|
22069488 |
2011 |
|
Amyotrophic Lateral Sclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations:</b> ALS: amyotrophic lateral sclerosis; CSF: cerebrospinal fluid; CERT: ceramide transfer protein; FFAT: two phenylalanines in an acidic tract; MSP: major sperm proteins; OSBP: oxysterol binding protein; PH: pleckstrin homology; PtdIns4P: phosphatidylinositol-4-phosphate; PtdIns4K: phosphatidylinositol 4-kinase; UPR: unfolded protein response; VAMP: vesicle-associated membrane protein; VAPA/B: mammalian VAPA and VAPB proteins; VAPs: VAMP-associated proteins (referring to <i>Drosophila</i> Vap33, and human VAPA and VAPB).
|
30741620 |
2019 |
|
Amyotrophic Lateral Sclerosis, Familial
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS).
|
22069488 |
2011 |
|
Amyotrophic Lateral Sclerosis, Familial
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The Pro56Ser mutation in the human VAPB MSP domain causes a familial amyotrophic lateral sclerosis.
|
20377183 |
2010 |
|
Angelman Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Q-MSP can detect both PWS and AS, as well as determine the parent of origin for the allele that carries the PWS/ASCR gains.
|
22426236 |
2012 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Within the ID cohort, behaviour impairment and MSP (i.e. moderate, severe, or profound) ID was associated with increased prescription of anxiolytics, both among those with anxiety (1.15 [1.03-1.30] for behaviour impairment and 1.23 [1.10-1.38] for MSP ID) and among those with mood disorders (1.14 [0.97-1.35] for behaviour impairment and 1.26 [1.04-1.52] for MSP ID).
|
31370823 |
2019 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Within the ID cohort, behaviour impairment and MSP (i.e. moderate, severe, or profound) ID was associated with increased prescription of anxiolytics, both among those with anxiety (1.15 [1.03-1.30] for behaviour impairment and 1.23 [1.10-1.38] for MSP ID) and among those with mood disorders (1.14 [0.97-1.35] for behaviour impairment and 1.26 [1.04-1.52] for MSP ID).
|
31370823 |
2019 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The promoters of the RASSF1A (3p21.3), BLU (3p21.3) and MGMT (10q26) genes were analyzed by MCA-MSP and MCA-Meth in 13 astrocytoma samples, 6 high grade glioma cell lines and 4 neuroblastoma cell lines.
|
18298842 |
2008 |
|
Basophilia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
INV(12) (p13q11) and dicentric chromosomes in a secondary leukaemia with basophilia.
|
2129034 |
1991 |
|
Benign Mastocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After oral immunization of BALB/c mice with two 1 x 10(9) colony forming unit doses given 21 days apart, CVD 908 omega (delta aroC::Ptac-gp63) elicited a broad T cell-mediated immune response against L. m. mexicana gp63 as demonstrated by: (1) lymphoproliferative response to fixed whole L. m. mexicana promastigotes; (2) activation of IL-2 (but not IL-4)-producing lymphocytes; (3) appearance of cytotoxic T cells against mouse mastocytoma cells expressing gp63.
|
9682357 |
1998 |
|
Benign Prostatic Hyperplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The methylation of GSTP1 and RASSF1A was investigated by using the MSP in 50 prostate cancer and 17 benign prostate hyperplasia specimens.
|
25577235 |
2015 |
|
Benign Prostatic Hyperplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our objective was to determine the gene expression pattern of the SFRP family in prostatic cell lines and fresh frozen tissues from normal prostates (NP), benign prostatic hyperplasia (BPH) and prostate cancer (PCa), by qRT-PCR, and their DNAme status by MSP and bisulfite sequencing.
|
27570179 |
2016 |
|
Biliary Atresia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification, genomic organization, chromosomal mapping and mutation analysis of the human INV gene, the ortholog of a murine gene implicated in left-right axis development and biliary atresia.
|
11935322 |
2002 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
To that end, we compare results from two different linkage meta-analysis methods--GSMA and MSP--applied to the same set of 13 bipolar disorder and 16 schizophrenia GWLS datasets.
|
21559500 |
2011 |
|
Blood spots
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blood spots were also collected on filter paper and subsequently used to evaluate the presence of serological markers (combined AMA-1 and MSP-119) of Plasmodium falciparum exposure.
|
21569328 |
2011 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Met-DNA in serum detected with the OS-MSP assay constitutes a significant and independent prognostic factor, and its combination with total DNA in serum seems to be even more effective for prediction of prognosis for breast cancer patients.
|
22964822 |
2012 |