CD2, CD2 molecule, 914

N. diseases: 50; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.310 GeneticVariation disease BEFREE Recently, several unbiased approaches have identified an association between polymorphisms of the CD2 gene, and rheumatoid arthritis (RA) susceptibility. 27385538 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 GeneticVariation disease UNIPROT
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 GeneticVariation phenotype BEFREE The protease-resistant properties of the erythrocyte receptor suggests that it is not glycophorin A or C. Additionally, analysis of mutant erythrocytes from humans has shown that EBA140 does not bind glycophorin B. Interestingly, we have identified a parasite line that lacks the eba140 gene, suggesting that this protein is not essential for in vitro invasion. 11454199 2001
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.020 GeneticVariation disease BEFREE An unusual neoplasm, best classified as a B-cell chronic lymphocytic leukemia on the basis of cytofluorographic, immunohistologic, and gene rearrangement analysis also co-expressed the T-cell associated marker CD2 (sheep erythrocyte receptor), but without other cell markers restricted to T cells. 7915983 1994
CUI: C0023418
Disease: leukemia
leukemia 		0.010 GeneticVariation disease BEFREE The evidence does not support the hypothesis that inappropriate surface expression of lineage markers is due to leukemia-related genetic changes, such as amplification or rearrangement, of the CD2 gene itself. 7719236 1995
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris 		0.010 GeneticVariation disease BEFREE Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. 15589166 2004
CUI: C0024138
Disease: Lupus Erythematosus, Discoid
Lupus Erythematosus, Discoid 		0.010 GeneticVariation disease BEFREE Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. 15589166 2004
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.010 GeneticVariation disease BEFREE Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. 15589166 2004
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.010 GeneticVariation disease BEFREE Transgenic overexpression of Batf under the control of the CD2 promoter/enhancer augmented lung inflammation and IgE levels in the setting of experimental asthma. 24290279 2014
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 GeneticVariation disease BEFREE Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. 11691816 2001
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.010 GeneticVariation disease BEFREE Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. 15589166 2004
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 GeneticVariation disease BEFREE The evidence does not support the hypothesis that inappropriate surface expression of lineage markers is due to leukemia-related genetic changes, such as amplification or rearrangement, of the CD2 gene itself. 7719236 1995
CUI: C1868683
Disease: B-CELL MALIGNANCY, LOW-GRADE
B-CELL MALIGNANCY, LOW-GRADE 		0.010 GeneticVariation disease BEFREE An unusual neoplasm, best classified as a B-cell chronic lymphocytic leukemia on the basis of cytofluorographic, immunohistologic, and gene rearrangement analysis also co-expressed the T-cell associated marker CD2 (sheep erythrocyte receptor), but without other cell markers restricted to T cells. 7915983 1994
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.010 GeneticVariation disease BEFREE Transgenic overexpression of Batf under the control of the CD2 promoter/enhancer augmented lung inflammation and IgE levels in the setting of experimental asthma. 24290279 2014
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.310 Biomarker disease CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.300 Biomarker group CTD_human Nephrotic syndrome associated with chronic lymphocytic leukemia: an immunological and pathological study. 2465858 1989
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.300 Biomarker phenotype CTD_human Occurrence of thrombotic events in acute promyelocytic leukemia correlates with consistent immunophenotypic and molecular features. 16932337 2007
CUI: C0087086
Disease: Thrombus
Thrombus 		0.300 Biomarker phenotype CTD_human Occurrence of thrombotic events in acute promyelocytic leukemia correlates with consistent immunophenotypic and molecular features. 16932337 2007
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE The DARC also functions as the erythrocyte receptor for invasion by malarial parasites. 12087071 2002
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE Unlike the case in Asia and Latin America, <i>Plasmodium vivax</i> infections are rare in sub-Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only known erythrocyte receptor for the <i>P. vivax</i> merozoite invasion ligand, Duffy binding protein 1 (DBP1).However, <i>P. vivax</i> infections have been documented in Duffy-negative individuals throughout Africa, suggesting that <i>P. vivax</i> may use ligands other than DBP1 to invade Duffy-negative erythrocytes through other receptors.To identify potential <i>P. vivax</i> ligands, we compared parasite gene expression in <i>Saimiri</i> and <i>Aotus</i> monkey erythrocytes infected with <i>P. vivax</i> Salvador I (Sal I). 30872477 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE RH5 is a leading subunit vaccine candidate because anti-RH5 antibodies inhibit parasite growth and the interaction with its erythrocyte receptor basigin is essential for invasion. 28186186 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE They both share homology of domain structure, including the binding region (Region II), which consists of two homologous F1 and F2 domains and is responsible for ligand-erythrocyte receptor interaction during merozoite invasion. 26439848 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE The molecular mechanism(s) responsible for these host restrictions are not understood, although the interaction between the parasite blood-stage invasion ligand EBA175 and the host erythrocyte receptor Glycophorin-A (GYPA) has been implicated previously. 24297912 2013
CUI: C0017638
Disease: Glioma
Glioma 		0.020 Biomarker disease BEFREE We previously demonstrated that administration of membrane glycopeptides T11 target structure (T11TS) not only rejuvenate bone marrow hematopoietic stem cells (BMHSCs) from glioma mediated hibernation by inhibiting gliomagenic overexpression of Ang-1/Tie-2 but also stimulate glioma mediated diminution of expression CD34, c-kit, and Sca-1 markers. 28233371 2018