Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A uterine leiomyoma showing both t(12;14) and del(7) abnormalities.
|
2702616 |
1989 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas.
|
9892177 |
1999 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As an initial step toward finding the gene or genes that are interrupted by the translocation breakpoint, a somatic cell hybrid carrying the derivative 14 as the single t(12;14) translocated chromosome was constructed from a leiomyoma cell line with this translocation.
|
7533530 |
1994 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Fluorescence in situ hybridization (FISH) analysis showed that this contig spanned the t(12;14) breakpoints in three uterine leiomyomas and that the breakpoints in these tumors occurred within a 1 Mb region.
|
9585056 |
1998 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma.
|
10565301 |
1999 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our efforts have focused on cloning the t(12;14)(q14-q15;q23-q24) breakpoint in uterine leiomyoma to further our understanding of the biology of these tumors.
|
7601452 |
1995 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Precise mapping of t(12;14) leiomyoma breakpoint on chromosome 14 between D14S298 and D14S540.
|
7585464 |
1995 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Shrinkage effect of gonadotropin releasing hormone agonist treatment on uterine leiomyomas and t(12;14).
|
11788889 |
2002 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Such similarity in chromosomal rearrangements suggests that there may be a pathogenetic relationship between IVL and uterine leiomyomata with t(12;14).
|
11904348 |
2002 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The cytogenetic profiles of leiomyoma and lipoma are strikingly similar; both tumor types have nonrandom rearrangements of 12q13-15, t(12;14) in leiomyoma and t(3;12) in lipoma, as well as variant rearrangements of the same 12q segment.
|
2278965 |
1990 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The finding in these leiomyosarcomas of rearrangements of the same regions of chromosomes 12 and 14 that are involved in the tumor-specific t(12;14)(q14-15;q23-24) of uterine leiomyoma indicates that the same genes in 12q and 14q might be important in the pathogenesis of benign and malignant smooth muscle tumors.
|
2397453 |
1990 |
Uterine Fibroids
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The three previously identified cytogenetic subgroups were all represented in this series: del(7) (q21.2q31.2) was found in 11, trisomy 12 in five, and t(12;14)(q14-15;q23-24) in one leiomyoma.
|
2227952 |
1990 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that t(12;14) breakpoints contribute to the pathogenesis of uterine leiomyoma by interrupting a complex regulation of HMGA2 and other genes embedded within and around it.
|
17045619 |
2006 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Three UL t(12;14) breakpoints have been localized within this contig, showing that a BCR of at least 400 kb exists on chromosome 14.
|
9740667 |
1998 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Unsupervised hierarchical clustering demonstrated that patient variability is relatively dominant to the distinction of t(12;14) UL compared with non-t(12;14) UL or of t(12;14) UL compared with del(7q) UL.
|
22343407 |
2012 |
Uterine Fibroids
|
0.100 |
Biomarker
|
group |
BEFREE |
Using fluorescence in situ hybridization and radiation hybrid mapping, we map ESR2 within 14q23-24.1, to a region approximately 2 Mb centromeric to the t(12;14) breakpoint in uterine leiomyomata, between markers D14S63 and WI-7536.
|
9824210 |
1998 |