Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition, ISG15 and UbcH8 promote breast cancer cell migration.
|
22185919 |
2012 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, we identified 45 significant miRNA-gene pairs that predict overall survival in breast cancer out of 170 one-on-one interactions in our reconstructed network covering all of five miRNAs, and several essential factors such as PSMB9, HLA-C, RARRES3, UBE2L6, and NMI.
|
30859354 |
2019 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
First, short hairpin RNA-mediated knockdown of either ISG15 or UbcH8 (major E2 for ISG15) in breast cancer ZR-75-1 cells decreased CPT sensitivity, suggesting that ISG15 overexpression in tumors could be a factor affecting intrinsic CPT sensitivity in tumor cells.
|
18566215 |
2008 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition, ISG15 and UbcH8 promote breast cancer cell migration.
|
22185919 |
2012 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
First, short hairpin RNA-mediated knockdown of either ISG15 or UbcH8 (major E2 for ISG15) in breast cancer ZR-75-1 cells decreased CPT sensitivity, suggesting that ISG15 overexpression in tumors could be a factor affecting intrinsic CPT sensitivity in tumor cells.
|
18566215 |
2008 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, we identified 45 significant miRNA-gene pairs that predict overall survival in breast cancer out of 170 one-on-one interactions in our reconstructed network covering all of five miRNAs, and several essential factors such as PSMB9, HLA-C, RARRES3, UBE2L6, and NMI.
|
30859354 |
2019 |
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Through gene expression analyses in a cohort of 98 acute myeloid leukemia (AML) patient samples and in primary neutrophils from healthy donors, we found that UBE2L6 gene expression is reduced in primary AML cells compared to normal mature granulocytes.
|
31820845 |
2019 |
Leukemia, Myelocytic, Acute
|
0.020 |
Biomarker
|
disease |
BEFREE |
Knockdown of UbcH8 by small hairpin RNAs (shRNAs) prevented HNK-induced degradation of AML-ETO, suggesting that UbcH8 plays a critical role in the degradation of AML1-ETO.
|
28043811 |
2017 |
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous gene expression studies in acute promyelocytic leukemia (APL) cells showed that all-trans-retinoic acid (ATRA) altered the expression of many genes, including UBE2L6 (200-fold) and other members of the ISGylation pathway.
|
31820845 |
2019 |
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
UbcH8 may have a utility as a biomarker of treatment response to bortezomib in patients with APL.
|
26026090 |
2015 |
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies suggest that UHRF1/ UbcH8 can be manipulated for therapy in cervical cancer.
|
29157076 |
2018 |
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These data identify UBE2L6 and ISG15 as novel inhibitors of autophagy, with the potential to influence chemosensitivity in esophageal cancer cells.
|
28186990 |
2017 |
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.
|
28043811 |
2017 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
First, short hairpin RNA-mediated knockdown of either ISG15 or UbcH8 (major E2 for ISG15) in breast cancer ZR-75-1 cells decreased CPT sensitivity, suggesting that ISG15 overexpression in tumors could be a factor affecting intrinsic CPT sensitivity in tumor cells.
|
18566215 |
2008 |
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Outcross populations of these models have been employed in the genome-wide search for mouse diabetes genes, and have led to positional cloning of the strong candidates Pctp, Tbc1d1, Zfp69, and Ifi202b (NZO-derived obesity) and Sorcs1, Lisch-like, Tomosyn-2, App, Tsc2, and Ube2l6 (obesity caused by the ob or db mutation).
|
24752583 |
2014 |
Esophageal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data identify UBE2L6 and ISG15 as novel inhibitors of autophagy, with the potential to influence chemosensitivity in esophageal cancer cells.
|
28186990 |
2017 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies suggest that UHRF1/ UbcH8 can be manipulated for therapy in cervical cancer.
|
29157076 |
2018 |
Malignant neoplasm of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data identify UBE2L6 and ISG15 as novel inhibitors of autophagy, with the potential to influence chemosensitivity in esophageal cancer cells.
|
28186990 |
2017 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we showed that TNF-α, similar to the response by IFN-β, could directly induce expression of ISG15 and its conjugation machinery, UbE1L and UbcH8, in human lung carcinoma, A549.
|
31428903 |
2019 |
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.
|
28043811 |
2017 |
PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE
|
0.010 |
Biomarker
|
disease |
BEFREE |
Parkin, the causative gene of AR-JP, encodes a 52-kDa protein that is a RING-type ubiquitin (Ub) protein ligase (E3) collaborating with a Ub-conjugating enzyme (E2) belonging to a cognate class of UbcH7 or UbcH8.
|
11692161 |
2001 |
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among the previously unreported Vpu targets identified by this approach, we find that the E2 ligase mediating ISG15 conjugation, UBE2L6, and the transmembrane protein PLP2 are targeted by Vpu during HIV-1 infection to facilitate late-stage replication.
|
29490283 |
2018 |
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of particular interest, we found that aberrant lipid turnover was controlled by UbcH8 in NPC through ISG15-conjugation of valosin-containing protein (VCP).
|
26506425 |
2015 |
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies suggest that UHRF1/ UbcH8 can be manipulated for therapy in cervical cancer.
|
29157076 |
2018 |
Influenza
|
0.300 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |