|
Malignant neoplasm of breast
|
0.340 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Carcinogenesis
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
<b>Conclusion</b>: These results demonstrate a pathway by which EBV(LMP1)-associated metabolite changes inhibited necroptosis signaling by DNA methylation, and shed light on the mechanism underlying EBV-related carcinogenesis, which may provide new options for cancer diagnosis and therapy.
|
31131045 |
2019 |
|
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EBV infection was analyzed at the cellular level by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization (ISH) and by LMP-1 protein immunohistochemistry (IHC).
|
10414496 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Neoplasms with sufficient tissue (22 of 25) were evaluated immunohistochemically for Ki-67, p53, chromogranin, synaptophysin, placental alkaline phosphatase (PLAP), CD99, carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), neuron-specific enolase (NSE), and latent membrane protein-1 (LMP-1).
|
11176064 |
2001 |
|
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EBV infection was determined by detection of early viral RNA sequences (EBER) and latent membrane protein (LMP-1) expression.
|
11957138 |
2002 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Anaplastic large-cell lymphoma of T-cell type was consistently LMP 1-negative.
|
1318639 |
1992 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anaplastic large-cell lymphoma of T-cell type was consistently LMP 1-negative.
|
1318639 |
1992 |
|
Childhood Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anaplastic large-cell lymphoma of T-cell type was consistently LMP 1-negative.
|
1318639 |
1992 |
|
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EBV infection or stable expression of LMP1 also induced CCL17 and CCL22 in a B-cell line, BJAB.
|
14747532 |
2004 |
|
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EBV infection is associated with virtually all cases of undifferentiated NPC, and the EBV-encoded LMP1 is expressed in a proportion of cases.
|
15352039 |
2004 |
|
Niemann-Pick Disease, Type C
|
0.100 |
Biomarker
|
disease |
BEFREE |
NPC is tightly linked to Epstein-Barr virus (EBV), however, only a small subset of EBV genes are expressed, among them the latent membrane protein 1 (LMP1).
|
16154221 |
2006 |
|
Pyothorax-Associated Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
PAL is strongly associated with Epstein-Barr virus (EBV) infection with expression of EBV latent genes such as EBNA-2, LMP-1, together with EBNA-1.
|
16330929 |
2005 |
|
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EBV infection and LMP-1 induced CCL20 mRNA expression in the EBV-negative Burkitt lymphoma (BL) cell lines and the embryonic kidney cell line.
|
16409294 |
2006 |
|
Epstein-Barr Virus Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EBV infection is associated with c-met abnormal expression but not with c-myc protein in EBVaGC. c-met overexpression is not induced by LMP1.
|
16609989 |
2006 |
|
Nasopharyngeal carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1).
|
16648906 |
2006 |
|
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
EBV infection was localized by EBV-encoded RNA (EBER) in situ hybridization and by immunohistochemical stains for viral latent proteins LMP1 and LMP2 and for viral lytic proteins BMRF1 and BZLF1.
|
22410851 |
2012 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Lymphomas in OKT3-treated animals (in contrast to lymphomas in the untreated animals) contained many LMP1-expressing cells.
|
22623780 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor cells from approximately 40% of patients with Hodgkin or non-Hodgkin lymphoma express the type II latency Epstein-Barr virus (EBV) antigens latent membrane protein 1 (LMP1) and LMP2, which represent attractive targets for immunotherapy.
|
24344220 |
2014 |
|
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
EBV infection was detected with in situ hybridization for EBV-encoded RNAs (EBERs) and by immunohistochemical staining for latent membrane protein 1 (LMP-1).
|
7637746 |
1995 |
|
Gastric Carcinoma with Lymphoid Stroma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Gastric lymphoepithelioma-like carcinoma and jejunal B-cell MALT lymphoma with large cell transformation. Demonstration of EBV with identical LMP gene deletions in the carcinoma and large cell lymphoma.
|
8623763 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumors from both patients with AIDS-associated non-Hodgkin's lymphoma were EBV-positive and expressed LMP1, whereas tumors from all three patients with Burkitt's tumors were positive for EBV but negative for LMP1.
|
9580648 |
1998 |
|
Nasopharyngeal carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LMP-1 expression might have worsened the prognosis of NPC in our series.
|
11913680 |
2002 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
LMP-1 30 bp deletion was found in high frequency in both non-neoplastic tonsils (92%) and malignant lymphomas (86%).
|
11920819 |
2002 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LMP-1 was detected in six middle ear aspirate specimen from three patients in group I who had petrous apex invasion.
|
12618203 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LMP-1 was expressed in 15 (48%) tumors, and p53 and beta-catenin protein were overexpressed in 18 (56%) and 4 (13%) tumors, respectively.
|
14745729 |
2004 |