CD14, CD14 molecule, 929

N. diseases: 551; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome
0.010 Biomarker disease BEFREE In patients with early disease, only 2 out of 11 patients (18%) with RA or RARS, according to WHO classification, had clonal granulocytes and CD14(+) cells in peripheral blood and bone marrow and 2 other patients with 5q-syndrome exhibited extremely oligoclonal granulocyte subpopulation in bone marrow. 15725470 2005
CUI: C3536715
Disease: AA amyloidosis
AA amyloidosis
0.010 GeneticVariation disease BEFREE To investigate the association between CD14 promotor C-159T polymorphism and development of amyloidosis, one hundred and forty-six patients who had FMF and had not developed amyloidosis; 26 with FMF and secondary amyloidosis and 92 controls were genotyped at the CD14-C159T locus. 17187267 2007
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.010 Biomarker group BEFREE CD14(+) macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide. 26475133 2015
CUI: C0151332
Disease: Active tuberculosis
Active tuberculosis
0.010 Biomarker disease BEFREE The present study analysed the apoptosis of CD14+ in the peripheral blood of patients with active tuberculosis, disposed the THP‑1 human monocytic cell line by BCG and examined the expression of miR‑155. 26324048 2015
CUI: C0263678
Disease: Acute arthritis
Acute arthritis
0.010 GeneticVariation disease BEFREE CD14 and TNfa promoter polymorphisms in patients with acute arthritis. Special reference to development of chronic spondyloarthropathy. 12492251 2002
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.030 AlteredExpression disease BEFREE The frequency of circulating CD14(+)HLA-DR(-/low) MDSCs; arginase-1 (Arg-1) expression; and plasma levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and IL-33 were markedly increased in ACS patients compared to stable angina (SA) or control patients. 25591771 2015
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.030 Biomarker disease BEFREE Circulating peripheral CD14++CD16+ monocytes expressed PSGL-1 more frequently than CD14++CD16- and CD14+CD16+ monocytes in patients with ACS. 24583418 2014
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.030 GeneticVariation disease BEFREE The CD14 C(-260)T polymorphism is associated with a history of ACS and it may represent a genetically determined risk factor for the development of ACS and atheromatous plaque vulnerability in angina patients. 15686783 2005
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.020 GeneticVariation disease BEFREE The aim of this study was to assess whether the C(-260)T polymorphism in the promoter of the CD14 receptor gene is associated with a higher prevalence of acute coronary syndromes (ACS) and severity of coronary atherosclerosis. 15686783 2005
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.020 AlteredExpression disease LHGDN CD14(+) monocyte percentages can be a useful parameter in differentiating between the subgroups of ACS, especially between UA and myocardial infarction. 17925604 2007
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.010 Biomarker disease BEFREE The frequency of CD14(+)HLA-DR(low/neg) cells was significantly increased after allo-HSCT, especially in patients with acute graft-versus-host disease. 22828446 2013
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.010 AlteredExpression disease BEFREE Two cases were classified by immunological phenotyping as acute null-AL(L), one case as pre B-cell ALL (CD10+) and two cases expressed both immature B-cell markers CD19 and CD24 and myelomonocytic markers CD15 and CD14, suggesting mixed lineage leukemia. 1375695 1992
CUI: C1959859
Disease: Acute lyme disease
Acute lyme disease
0.010 AlteredExpression disease BEFREE The concentrations of MMP-9 and soluble CD14 were markedly elevated in serum from patients with acute Lyme disease and were also upregulated in U937 cells by B. burgdorferi in a time- and concentration-dependent manner. 17403874 2007
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.010 GeneticVariation disease BEFREE The findings suggest that CD14-260C/T polymorphism can contribute to B-ALL risk in a Chinese population. 21476947 2011
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.010 AlteredExpression disease BEFREE Here, we identified the differential expression of TLR4 and CD14 receptors in AML cell lines and examined their relationship to FA sensitivity. 30336978 2018
Acute Myeloid Leukemia with Myelodysplasia-Related Changes
0.010 AlteredExpression disease BEFREE Monocytes in AML-MRC had lower expression of CD14, CD56 and CD45. 27387988 2017
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1
0.010 AlteredExpression disease BEFREE Relatively undifferentiated leukemic myeloblasts with an HLA-DR, CD34, CD33, CD13+/- cell surface immunophenotype (French-American-British [FAB] M1 or M2) were characterized by a lack of c-fms and c-fgr expression, while low levels of c-fms and c-fgr could be detected in undifferentiated myeloblasts (FAB M1 or M2), which also expressed CD14 at low antigen density. 1825181 1991
CUI: C0023479
Disease: Acute myelomonocytic leukemia
Acute myelomonocytic leukemia
0.020 Biomarker disease BEFREE Using CD11b, CD14, and other myeloid markers, we found that AML M4 and AML M5 were characterized by dual populations of blasts. 9052378 1997
CUI: C0023479
Disease: Acute myelomonocytic leukemia
Acute myelomonocytic leukemia
0.020 AlteredExpression disease BEFREE We conclude that although cases with high blast cell CD14 expression (and FAB-M4 cases) were more resistant to Ara-C as well as Dau in vitro, the clinical and biological significance of this may be debatable because of interactions with major prognostic factors in AML. 11860442 2001
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.080 Biomarker disease BEFREE We aimed to investigate changes in the levels of cytokines (IL-6, TNF-α and IL-10), miRNAs profiles (miR-146 and miR-155) and distribution of different monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16++) in the acute and post-healing phases of AMI. 30481637 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.080 GeneticVariation disease BEFREE The frequencies of T allele and T/T homozygotes in patients with AMI were significantly higher than in controls and in patients with angina without prior AMI, suggesting that the CD14 promoter polymorphism is associated with AMI rather than with coronary atherosclerosis, and this polymorphism may be one of the genetic risk factors for AMI in Japanese men. 10980225 2000
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.080 Biomarker disease BEFREE Polymerase chain reaction detection of chlamydial DNA was applied to CD14-positive cells collected from 238 patients with angiographically identified unstable angina or acute myocardial infarction. 10839736 2000
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.080 GeneticVariation disease BEFREE The IL6 -174G>C and CD14 -260C>T polymorphisms are likely to be associated with a pro-atherogenic profile but not with increased inflammatory markers and endothelial dysfunction in young AMI patients. 23135962 2013
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.080 GeneticVariation disease BEFREE To investigate the possible association between CD14 C(-260)T (rs2569190) gene polymorphism and the risk of acute myocardial infarction in the Egyptian population. 29874995 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.080 GeneticVariation disease BEFREE In the present study we investigated a possible association between the C(-260)T polymorphism in the CD14 promoter and acute myocardial infarction. 14648231 2003