Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis.
|
28181566 |
2017 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This and other single-nucleotide polymorphisms have been associated with hypertension and adiponectin level in separate studies.
|
21872196 |
2011 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of adiponectin gene polymorphisms with hypertensive disorder complicating pregnancy and disorders of lipid metabolism.
|
26634484 |
2015 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The risk of high blood pressure (≥160/110 mm Hg) and of high serum adiponectin in T-allele carriers at +276G/T in the severe preeclamptic group were 5.345 and 5.818 times higher, respectively, compared with GG patients.
|
20664545 |
2010 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs.
|
23845780 |
2013 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms (SNPs) -11377C/G (rs266729) and +276G/T (rs1501299) in ADIPOQ (adiponectin gene) were associated with hypertension.
|
25546819 |
2015 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Haplotype TGTG from adiponectin gene variants 45T/G and 276G/T is related to susceptibility to PCOS, and might be associated with increased blood pressure in PCOS.
|
23685884 |
2014 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In a Poisson model comprising age, sex, smoking habits, BMI, HbA1c, total cholesterol, HDL-cholesterol, triglycerides, insulin therapy and hypertension, both rs822354 (IRR = 1.94, 95 % CI 1.23-3.07; p = 0.005), as well as the genetic equivalent of total adiponectin change (IRR = 1.07, 95 % CI 1.02-1.12; p = 0.003) were significantly associated with cardiovascular mortality.
|
26817832 |
2016 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The MHO individuals with abnormal adipokines were significantly more likely to developing hypertension (high leptin, relative risk 11.04; 95% confidence interval, 1.18-103.35; and high leptin/adiponectin ratio, relative risk 9.88; 95% confidence interval, 1.11-87.97) compared to metabolically healthy normal-weight individuals with normal adipokine levels.
|
29093301 |
2018 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, a meta-analysis was performed to assess the associations of ADIPOQ polymorphisms with hypertension risk among the Chinese.
|
22714914 |
2012 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction.
|
18506375 |
2008 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Logistic regression analysis after adjustment for age, sex, adiponectin and S447X polymorphism demonstrated that LPL mass was inversely associated with CHD in men and both genders (p=0.02), with hypertension confined to women (p=0.04) and with MS likelihood in both genders combined and women [odds ratio 1.51 (95% CI 1.14-2.00) for halving the likelihood].
|
19191728 |
2009 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The adiponectin TG genotype may be associated with reduced HDL-C and the human paraoxonase 1 AA genotype with hypertension in males.
|
30381540 |
2018 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension.
|
15123570 |
2004 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Plasma adiponectin, T94G gene polymorphism and PAI-1 in patients with and without hypertension.
|
16741355 |
2007 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our findings suggested that in spite of the nonsignificant association between ADIPOQ T45G or G276T polymorphism and hypertension, the heterozygous mutation of G276T was observed to account for increased levels of circulating adiponectin and blood pressure, especially in hypertensive patients.
|
28099908 |
2017 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population.
|
16944773 |
2006 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Another intron SNP (rs12037879) in LEPR and a promoter region SNP (rs266729) in ADIPOQ were significantly associated with hypertension (P = 0.041 and 0.042, respectively).
|
24414038 |
2014 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Through multiple logistic regression analysis, the adiponectin +276 T allele carrier was found to be associated with an increased risk of hypertension (TT vs. GG and TG: odds ratio = 3.318, p = 0.014, 95% confidence interval: 1.269-8.678).
|
27936341 |
2017 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension.
|
21150884 |
2011 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
No association of ADIPOQ gene with HTN alone or MetS without HTN was observed.
|
21637762 |
2011 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
LHGDN |
Decreased plasma adiponectin concentration in patients with essential hypertension.
|
12517687 |
2003 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
LHGDN |
Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension.
|
17452504 |
2007 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Low plasma adiponectin concentrations are associated with myocardial infarction in individuals below the age of 60, and this remains significant after adjustment for history of hypertension, HDL cholesterol, smoking and BMI.
|
20528971 |
2010 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, we have discussed the involvement of adiponectin in hypertension, endothelial dysfunction, inflammation, and proteinuria.
|
31746004 |
2020 |