Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS.
|
31341853 |
2019 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI.
|
31149031 |
2019 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin.
|
30813240 |
2019 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lower adiponectin levels have been associated with metabolic syndrome, type 2 diabetes, insulin resistance, cardiovascular diseases, and hypertension.
|
31121868 |
2019 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating adiponectin concentrations are reduced in obese individuals, and this reduction has been proposed to have a crucial role in the pathogenesis of atherosclerosis and cardiovascular diseases associated with obesity and the metabolic syndrome.
|
30857216 |
2019 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
An adverse adipokine panel that includes fetuin-A and adiponectin can potentially assess atherosclerotic risk in even those without MetS.
|
30835048 |
2019 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study.
|
29759068 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome.
|
30333754 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Results of this study indicate that leptin (15.92 ± 10.50 vs.9.43 ± 4.39 pg/ml, p < 0.001), L:A ratio (1.08 ± 1.06 vs.0.42 ± 0.38 pg/ml, p < 0.001), HOMA-IR, the lipid profile, and other metabolic risk factors (waist circumference (WC), waist-to-hip ratio(WHR), body mass index((BMI)), fasting plasma glucose (FPG) level and fasting plasma insulin(FPI)) were significantly higher but HDL, HDL/LDL and adiponectin level (20.55 ± 10.76 vs.30.08 ± 13.08 pg/ml, p < 0.001)were significantly lower in postmenopausal women with metabolic syndrome than in women without the syndrome (p < 0.001).
|
29410303 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lipodystrophy was only associated with increased macrophage infiltration (P = .04) and adiponectin messenger ribonucleic acid ([mRNA] P = .008), whereas metabolic syndrome was associated with larger adipocytes (P < .0001), decreased expression of genes related to adipogenesis and adipocyte function (P values between <.0001 and .08), increased leptin mRNA (P = .04), and a trend towards increased expression of inflammatory genes (P values between .08 and .6).
|
29788076 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
They reduced insulin level and resistance with increased adiponectin, and correction of MS-induced hyperlipidemia.
|
30256492 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consequently, the link between psychosocial stress and inflammatory diseases like the metabolic syndrome might be partially explained by lower adiponectin levels in stress.
|
28578188 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This emerging biomarker correlates with insulin resistance better than adiponectin or leptin alone, or even HOMA and is decreased with increasing number of metabolic risk factors having been proposed as a predictive marker for the MS.
|
29205099 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines related to insulin resistance and MetS in children are tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, interferon gamma, pigment epithelium-derived factor, chemerin, vaspin, and fetuin A. Anti-inflammatory cytokines associated with insulin resistance and MetS in children are leptin, adiponectin, omentin, fibroblast growth factor (FGF)-21, osteocalcin, and irisin.
|
30338401 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects.
|
30058513 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
AdipoRon, a potent adiponectin receptor agonist, prevented the corticosterone-induced early onset of moderate obesity and metabolic syndromes.
|
30115912 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transcription factors (AMP-activated protein kinase-1, STAT3, sterol regulatory element-binding protein-1 and peroxisome proliferator-activated receptor-γ), leptin and adiponectin receptors seem to be the most promising molecular targets for the therapy of cancers associated with MS.
|
29115033 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS.
|
30381540 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Currently adiponectin is being investigated as a potential therapeutic target for metabolic syndrome, although more research is required to understand the underlying mechanisms controlling adiponectin levels, including dietary and lifestyle interventions, that may target adiponectin as a therapeutic intervention in metabolic syndrome.
|
29395659 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The leptin and free leptin levels in plasma and SF were significantly higher in MetS-OA group than those in nMetS-OA group, while the adiponectin levels were lower (All p < 0.01).
|
29335849 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous studies evaluated the dietary habits and nutrient intakes among patients with metabolic syndrome; however the association between metabolic risk factors and adiponectin with dietary diversity score (DDS) in patients with metabolic syndrome has not been evaluated yet.
|
29665770 |
2018 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study aimed to compare the strength of association between MetS and leptin, adiponectin and L/A ratio, as well as to assess their performance to diagnose MetS in patients with schizophrenia.
|
29625373 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Tributyltin reduces the levels of serum adiponectin and activity of AKT and induces metabolic syndrome in male mice.
|
29675927 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we aimed to investigate the association of two intronic variants in ADIPOQ gene, -3971A>G (rs822396) and +276G>T (rs1501299) with obesity and metabolic syndrome.
|
30265726 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High serum adiponectin levels showed no inverse association with metabolic syndrome in postmenopausal women with obesity.
|
28763403 |
2018 |