|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Low adiponectin levels are commonly observed in human obesity and have been associated with increased pancreatic cancer risk in prospective epidemiologic studies.
|
30745818 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, adipose tissue from HFSD rats exhibited significantly larger adipocytes, displayed a significant upregulation of leptin and, surprisingly, elevated adiponectin levels, which is in contrast to chronic obesity in humans.
|
29907930 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin plays a role in asthma and obesity, but its effects and mechanism in obesity-related asthma remain elusive.
|
30584969 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum adiponectin concentration was negatively associated with body mass index, waist to hip ratio, low-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting glucose, fasting insulin, homeostatic model assessment of insulin resistance, dyslipidemia and overweight/obesity status (7.76 × 10<sup>-40</sup> ≤ p ≤ 3.00 × 10<sup>-3</sup>).
|
30816311 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin secreted from adipocytes into plasma has anti-aging, anti-obesity and anti-inflammation effects.
|
30474186 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In comparison, overweight/obese group showed a relatively stable adiponectin level throughout the cycle.
|
31647300 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adrenergic stimulation of adiponectin secretion in visceral mouse adipocytes is blunted in high-fat diet induced obesity.
|
31337827 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The increased levels of adipokines such as Leptin, IL-6 and TNF-α and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects.
|
30904536 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to determine whether concentration of plasma adiponectin and leptin differ between metabolic unhealthy obese (MUO) patients and comparable age- and sex-matched control groups.
|
31341853 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adipokines, including adiponectin, have been implicated as a factor linking obesity and carcinogenesis.
|
30967059 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the role of adiponectin in alleviating the hypothalamic inflammation connected to the pathogenesis of obesity has not yet been clearly interrogated.
|
31731705 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The presence of obesity at ≥ 2 follow-ups showed the highest mean values (SE) for IL-6 [2.45 (1.05)] and CRP [3.74 (1.11)] and the lowest mean value for adiponectin [8.60 (0.37)] (adjusted analyses, females) compared with other exposures; the highest mean of IL-6 [1.65 (1.05)] and CRP [1.78 (1.11)] and the lowest mean of adiponectin [9.98 (0.38)] were for the number of follow-ups with ≥2 exposures compared to those with no exposures at any follow-up (adjusted analyses, females).
|
31071114 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population.
|
30530892 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
A state of subclinical inflammation defined by an IS including TNF-alpha, IL-6, IL-8, IL-10, leptin and adiponectin is associated with obese RHTN.
|
30843931 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The associations between the obesity GRS and the measures of fasting insulin, HOMA-IR, and adiponectin were significant after adjusting for confounding factors.
|
30653656 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that, overall, both CGN and SCGN were more effective in reversing obesity and related metabolic syndromes to normal levels than T. Furthermore, these findings suggested that CGN- and SCGN-modulated gut dysbiosis induced by a high-fat diet, which may play an influencing role in adiponectin dysregulation.
|
31117266 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Beyond mechanical loading, adipokines, including leptin, visfatin, adiponectin, resistin and others, are demonstrated to have metabolic implications in the pathogenesis and progression in obesity-induced osteoarthritis by modulating the pro/anti-inflammatory and anabolic/catabolic balance, apoptosis, matrix remodeling and subchondral bone ossification.
|
30539776 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Maternal obesity is associated with alteration of immunological factors concentrations in the human milk, such as C-reactive protein (CRP), leptin, IL-6, insulin, TNF-Alpha, ghrelin, adiponectin, and obestatin.
|
31174304 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity as an Inflammatory Agent Can Cause Cellular Changes in Human Milk due to the Actions of the Adipokines Leptin and Adiponectin.
|
31146419 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Strategies aimed at improving maternal adiponectin levels may prevent long-term metabolic dysfunction in offspring of obese mothers.-Paulsen, M. E., Rosario, F. J., Wesolowski, S. R., Powell, T. L., Jansson, T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring.
|
30346829 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We also found that normal breast tissue samples with high leptin/adiponectin transcript ratio characteristic of obesity have an altered distribution of apical polarity markers.
|
30670780 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
CTRP3 levels inversely correlated with serum triglyceride (r = -0.09, P < 0.001), atherogenic index (r = -0.37, P = 0.04), leptin (r = -0.39, P = 0.02), and positively with adiponectin (r = 0.42, P = 0.02) in the group with obesity.
|
31372167 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin concentrations in the overweight/obese group were significantly lower than those in the lean group in the first and second trimesters.
|
30324835 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.
|
27236826 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results show that low serum adiponectin levels, but not those of other adipocytokines, are inversely associated with HBP; this association is independent of obesity.
|
31042407 |
2019 |