|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These novel data support the idea that the adiponectin-AdipoR1/2-APPL1 axis may serve as a potential therapeutic target for preventing macrophage foam cell formation and atherosclerosis.
|
22227293 |
2012 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several studies suggest an important role of adiponectin in the process leading to atherosclerosis, thus indicating the adiponectin gene as a potential candidate for coronary artery disease.
|
21738048 |
2011 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This may help in understanding the complex role that the adiponectin gene has in atherosclerosis.
|
21248784 |
2011 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The adipocytokines adiponectin and leptin have been suggested as risk factors for cardiovascular disease, including stroke, acting through atherosclerosis.
|
21474811 |
2011 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this review, we elaborate currently known information about Ad malfunction and deficiency pertaining to cardiovascular disease risk (including atherosclerosis, endothelial dysfunction, and cardiac injury), as well as review evidence supporting Ad resistance as a novel risk factor for cardiovascular injury, providing insight about the future of Ad research and the protein's potential therapeutic benefits.
|
21091079 |
2011 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adipocytokines such as tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), adiponectin, leptin, resistin along with peroxisome proliferator activated receptor-γ (PPAR-γ) are important mediators in glucose homeostasis in association with CD36 and can be used as markers for T2DM and atherosclerosis.
|
21262584 |
2011 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis.
|
20350970 |
2010 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CB1 receptor blockade reduced atherosclerosis in apoE-deficient mice through an increase in serum adiponectin levels and activation of the RCT system.
|
20124735 |
2010 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A large number of in vitro and in vivo studies support the beneficial effects of adiponectin on metabolic syndrome, diabetes, and atherosclerosis.
|
20232346 |
2010 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin is an insulin-sensitizing and anti-inflammatory fat cell hormone that has immense potential as a therapeutic target for a multitude of obesity-associated diseases, including type 2 diabetes, NASH and atherosclerosis (Chandran M, Phillips SA, Ciaraldi T, Henry RR: Adiponectin: more than just another fat cell hormone?Diabetes Care 2003, 26:2442-2450).
|
20810317 |
2010 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our studies provide new insights into potential mechanisms of adiponectin-mediated alterations in lipid metabolism and macrophage foam cell formation which may impact the development of atherosclerosis.
|
18511057 |
2009 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin has a variety of metabolic effects on obesity, insulin sensitivity, and atherosclerosis.
|
19165155 |
2009 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin is inversely associated with obesity, insulin resistance, and atherosclerosis, but little is known about the genetic pathways that regulate the plasma level of this protein.
|
19426517 |
2009 |
|
Atherosclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Adiponectin is an adipocyte-derived protein that acts to reduce insulin resistance in the liver and muscle and also inhibits atherosclerosis.
|
18931039 |
2009 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
A lack of increase in high molecular weight-adiponectin in macroalbuminuric subjects with metabolic syndrome may exert renal and atherosclerotic risks.
|
18006102 |
2008 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has been shown to contribute to the development of insulin resistance, type 2 diabetes, metabolic syndrome and atherosclerosis.
|
18054335 |
2008 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis.
|
18703020 |
2008 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease.
|
17495599 |
2007 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease.
|
17303804 |
2007 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the studies published to date indicate that polymorphisms at the adiponectin locus are indeed predictors of circulating adiponectin levels, insulin sensitivity, and atherosclerosis, highlighting the pivotal role of this adipokine in the modulation of metabolism and atherogenesis.
|
17303804 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Adiponectin (APN) secreted from adipocytes is also one of the important molecules to inhibit the development of atherosclerosis.
|
17521614 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the presence of adiponectin receptors in intra-abdominal adipose tissue (IAAT) in obesity and diabetes and their association with adiponectin expression and components of the metabolic syndrome and/or other metabolic factors associated with atherosclerotic cardiovascular disease (ASCVD).
|
16756736 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed the genetic basis of plasma adiponectin in Hispanic-American and African-American families enrolled through the Insulin Resistance Atherosclerosis Study Family Study.
|
16731835 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin, an adipose tissue-derived hormone, exhibits anti-inflammatory properties and has various biological functions, such as increasing insulin sensitivity, reducing hypertension, and suppressing atherosclerosis, liver fibrosis, and tumor growth.
|
16952554 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Plasma adiponectin and E-selectin concentrations in patients with coronary heart disease and newly diagnosed disturbances of glucose metabolism.
|
17357284 |
2006 |