|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML.
|
29209559 |
2017 |
|
Acute myeloid leukemia, minimal differentiation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, flow cytometry analysis of 20 samples of patients with acute myeloid leukemia (AML) (FAB M0-M5) revealed the expression of NKG2D (40%) and other natural cytotoxicity receptors (40% for NKp30, 74% for NKp44, 39% for NKp46) by a pool >15% of leukemic cells.
|
16239914 |
2005 |
|
Acute type B viral hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
It was found that NKp46(+) NK cells were enriched in the livers of AHB and CHB patients.
|
23133672 |
2012 |
|
Addison Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Phenotypically, the percentage of NK cells expressing the activating receptors NKG2D and NKp46 was significantly lower in PAI, as was the surface density of NKG2D (all <i>P</i> < 0.0001).
|
28223394 |
2017 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This enhanced killing depended on the NK cell natural cytotoxicity receptors (NCRs) NKp30 and NKp46, whose ligands are upregulated in oHSV-infected glioblastoma cells.
|
23178246 |
2012 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MiR-544 was upregulated while NCR1 and RUNX3 was downregulated in NK cells of patients with liver cancer.
|
29636640 |
2018 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Single cell suspensions from lymphoma tissue were expanded with anti-NKp46/anti-CD2-coated beads in the presence of IL-2.
|
31126350 |
2019 |
|
Anatomic Stage IIIA Breast Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD16, NKG2A, and NKp46 expression were shown to be increased in stage IIIA breast cancer patients.
|
30514793 |
2019 |
|
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In order to further validate de novo expression of NCR1 in astrocytes, we used an in vitro staining of the human astrocytoma U251 cell line grown to model whether cell stress could be associated with expression of NCR1.
|
22212381 |
2012 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections.
|
28643847 |
2017 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Celiac Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In paraffin biopsies, detection of >25 NKp46+ IEL per 100 epithelial cells discriminated RCDII from CD and RCDI.
|
30448772 |
2019 |
|
Childhood Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In order to further validate de novo expression of NCR1 in astrocytes, we used an in vitro staining of the human astrocytoma U251 cell line grown to model whether cell stress could be associated with expression of NCR1.
|
22212381 |
2012 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This enhanced killing depended on the NK cell natural cytotoxicity receptors (NCRs) NKp30 and NKp46, whose ligands are upregulated in oHSV-infected glioblastoma cells.
|
23178246 |
2012 |
|
Childhood Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our longitudinal study of AML patients showed that the NCR(dull) phenotype was acquired during leukemia development because we observed its complete (for NKp46) or partial (for NKp30) reversibility in patients achieving complete remission (CR).
|
16940427 |
2007 |
|
Childhood Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia.
|
21364281 |
2011 |
|
Childhood Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Single cell suspensions from lymphoma tissue were expanded with anti-NKp46/anti-CD2-coated beads in the presence of IL-2.
|
31126350 |
2019 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although entinostat upregulated ligands for the NK cell activating receptor on OS lung metastasis, it failed to augment the efficacy of NK cell therapy in our nude mouse human OS lung metastasis model.
|
28919994 |
2017 |
|
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Colorectal Carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high anti-tumor activity against colorectal cancer.
|
31689241 |
2019 |
|
Colorectal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Immunocompetent NCR1-GFP mice, in which NK cells express GFP, demonstrated GFP+ NK cell infiltration of syngeneic MC38 colorectal tumors.
|
29533922 |
2018 |
|
Complete atrioventricular block
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expressions of NKp46 and NKG2A were higher in CHB-H than in HS/CHB-L/CHB-NA.
|
28328926 |
2017 |
|
Complete atrioventricular block
|
0.020 |
Biomarker
|
disease |
BEFREE |
It was found that NKp46(+) NK cells were enriched in the livers of AHB and CHB patients.
|
23133672 |
2012 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
VHL-MUT-RCC tumors were NKp46<sup>+</sup> cells infiltrated and expressed high NKp30 and NKp46 receptors as compared to VHL-WT-RCC tumors.
|
30514329 |
2018 |