Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.620 CausalMutation disease CLINVAR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.620 Biomarker disease HPO
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.620 Biomarker disease CTD_human
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.100 Biomarker phenotype HPO
CUI: C4703555
Disease: Decreased waist to hip ratio
Decreased waist to hip ratio 		0.100 Biomarker phenotype HPO
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.620 GeneticVariation disease BEFREE Sibpair analyses performed on i49 multiplex French families with type 2 diabetes excluded MAPK8IP1 as a major diabetogenic locus. 10700186 2000
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.620 GeneticVariation disease UNIPROT Sibpair analyses performed on i49 multiplex French families with type 2 diabetes excluded MAPK8IP1 as a major diabetogenic locus. 10700186 2000
CUI: C0011847
Disease: Diabetes
Diabetes 		0.010 Biomarker disease BEFREE These data establish MAPK8IP1 as a candidate gene for human diabetes. 10700186 2000
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.010 Biomarker group BEFREE These data establish MAPK8IP1 as a candidate gene for human diabetes. 10700186 2000
CUI: C0021670
Disease: insulinoma
insulinoma 		0.010 AlteredExpression disease BEFREE We evaluated the role of IBi in beta-cells by expression of a MAPK8IP1 antisense RNA in a stable insulinoma beta-cell line. 10700186 2000
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.010 Biomarker disease BEFREE Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease. 11504916 2001
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease LHGDN In two separate French populations the -499A>G polymorphism of MAPK8IP1 was not associated with an increased risk to AD. 12740599 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE In two separate French populations the -499A>G polymorphism of MAPK8IP1 was not associated with an increased risk to AD. 12740599 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.010 AlteredExpression group LHGDN JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). 15138488 2004
CUI: C0039590
Disease: Testicular Neoplasms
Testicular Neoplasms 		0.010 AlteredExpression group LHGDN The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours. 15868948 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE However, this polymorphism increased the risk of AD conferred by the MAPK8IP1 G allele. 17614163 2009
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.020 AlteredExpression disease BEFREE When six primary Wilms tumours (nephroblastomas) from pig were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high or low expression of JIP-1 ocurred together. 20044608 2009
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.020 AlteredExpression disease BEFREE Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours. 19596915 2009
CUI: C4511452
Disease: Sporadic Parkinson disease
Sporadic Parkinson disease 		0.010 AlteredExpression disease BEFREE While no alterations in mRNA expression were observed, an increase in protein expression was observed in PD cases for GPx4 and MAPK8IP1. 19146923 2009
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.020 Biomarker disease BEFREE A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3. 23045411 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.020 Biomarker disease BEFREE A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3. 23045411 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.020 Biomarker disease BEFREE A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3. 23045411 2012
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE These findings suggest autophagy-related genes like MAPK8IP1 and SH3GLB1 could be potential therapeutic targets in glioma. 28977840 2017
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 AlteredExpression disease BEFREE A statistically significant inverse correlation was detected between miR-10a and MAPK8IP1 mRNA expression levels in GC specimens. 28454224 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.010 AlteredExpression group BEFREE GLP-1R activation by ex-4 resulted in reduction of COX-2 through increasing IB1 expression, resulting in anti-inflammatory neuroprotection during stroke. 28912645 2017