|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study indicates that flow cytometry can be used to examine the tumor microenvironment in HL and that percentage of HLA-DR/CD38 copositive lymphocytes may be a biomarker for relapse and refractoriness in pediatric HL.
|
30009533 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The presence of the t(X;18) with SSX2 involvement definitively characterizes this tumour as a variant of synovial sarcoma.
|
11207827 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The presence of t(X;3) with a breakpoint at band Xp11 as in synovial sarcoma may suggest a common histological origin of the two tumor types.
|
9530345 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CD38 expression of tumor cells has been identified as an important prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL).
|
16825496 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the possible mechanism, bioinformatics analysis and mass spectrometry technology was used to determine the most notably changing molecule and signaling pathways, and it was determined and verified that CD38 regulated the metabolic‑associated signaling pathways associated with tumor protein 53, hypoxia inducible factor‑1α and sirtuin 1.
|
30535454 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fluorescence in situ hybridization with custom probes was used to select t(X;18) positive tumors.
|
16740029 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocation t(X;6)(q13-14;q22).
|
16284948 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High coexpression of CD38/CD101 on peripheral PD-1<sup>+</sup>CD8<sup>+</sup> T cells or tumor-infiltrating lymphocytes (TILs) was found to be most significantly correlated with Tumor/Node/Metastasis (T/N/M) classification and clinical stage, in contrast PD-1<sup>+</sup>CD8<sup>+</sup> T cells could not correlate with T classification.
|
30689488 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Subungual exostosis is a benign bone- and cartilage-forming tumor known to harbor a pathognomonic t(X;6)(q22;q13-14).
|
20340132 |
2011 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Case report of a poorly differentiated uterine tumour with t(10;17) translocation and neuroectodermal phenotype.
|
21737666 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of YWHAE-FAM22 fusion oncoproteins was demonstrated by immunoblot in t(10;17)-bearing frozen tumor and cell line samples.
|
22223660 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, CD38 expression in tumor tissues was verified by histological analysis.
|
29450576 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There is increasing evidence that CD38 antibodies also improve host-anti-tumor immune response by eliminating CD38-positive immune suppressor cells, including regulatory T cells, regulatory B cells, and myeloid-derived suppressor cells.
|
29702148 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cells with the phenotype of tumor plasma cells (CD38(++)CD19(-)CD45(-/+)CD56(-/+/++)) or memory B cells (CD38(-)/CD19(+)/CD27(+)) were isolated by flow activated cell sorting.
|
20511669 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In human xenograft MM tumor models, anti-CD38-IFNα(attenuated) exerts potent anti-tumor activity in mice, inducing complete tumor regression in most cases.
|
27611189 |
2016 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SS bear the t(X;18)(p11.2,q11.2) translocation, which proved to be specific for this tumor type and is currently considered one of the most reliable diagnostic criteria.
|
12409719 |
2002 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14).
|
1683261 |
1991 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In all, taking these results together with findings of 20 previously published synovial sarcoma tumors with complex t(X;18), 13 different chromosomes were involved.
|
19215793 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Daratumumab augments alloreactive natural killer cell cytotoxicity towards CD38+ multiple myeloma cell lines in a biochemical context mimicking tumour microenvironment conditions.
|
29500635 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The presence of an SYT-SSX gene fusion resulting from the t(X;18) characteristic of synovial sarcoma was demonstrated by reverse transcriptase polymerase chain reaction in three of three tumors in which adequate RNA could be obtained from paraffin blocks.
|
10935649 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lastly, blocking CD38 expression improved tumor control even when using Th0 anti-tumor T cells.
|
29129787 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, paraffin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated for the presence of t(X;18) by reverse transcriptase-polymerase chain reaction.
|
11106084 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
G-banded analysis demonstrated the first tumor to have a karyotype of 46,Y,t(X;3;14)(q13;p25;q21)[15]/46XY[5], and the second tumor to have a karyotype of 46, XY,add(2)(q31),add(4)(q31.1)[2]/92,slx2[3]/46,sl,der(2)t(2;4)(q14.2;p14),der(4)t(2;4)(q14.2;p14),add(4)(q31.1)[10]/46,sdl,add(13)(q34)[4]/92,sdl2x2[1].
|
22503486 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There is increasing evidence that CD38 antibodies also improve host-anti-tumor immune response by eliminating CD38-positive immune suppressor cells, including regulatory T cells, regulatory B cells, and myeloid-derived suppressor cells.
|
30826127 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Cytogenetically, they are characterized by translocation t(X;18), which is found in more than 95% of tumors.
|
15747098 |
2005 |