Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Bag3opathy is a rare myofibrillar myopathy (MFM) caused by a mutation in the Bcl-2 associated-athanogene-3 gene.
|
30061062 |
2018 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Bcl-2-associated athanogene-3 (BAG3) mutations have been described in rare cases of rapidly progressive myofibrillar myopathies.
|
28224639 |
2018 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that the BAG3 variant of myofibrillar myopathy may result from a spontaneous mutation at an early point of embryonic development and that transmission from a mosaic parent may occur more than once.
|
20605452 |
2010 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The most important recent advance in the MFMs has been the identification of mutation in Bag3 (Bcl-2-associated athanogene-3) as a new cause of MFM.
|
20664348 |
2010 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge this is the first study reporting, in a BAG3 MFM, the simultaneous presence of genetic variants in the BAG3 and FHL1 genes (previously described as independently associated with MFMs) and linking the NRAP gene to MFM for the first time.
|
27443559 |
2016 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We therefore searched for mutations in BAG3 in 53 unrelated MFM patients.
|
19085932 |
2009 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Unusual multisystemic involvement and a novel BAG3 mutation revealed by NGS screening in a large cohort of myofibrillar myopathies.
|
25208129 |
2014 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To investigate the mechanism of disease in BAG3-related MFM, we expressed wild-type BAG3 or the dominant MFM-causing BAG3 (BAG3(P209L)) in zebrafish.
|
25273835 |
2014 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Myofibrillar myopathies (MFM) are a group of disorders associated with mutations in DES, CRYAB, MYOT, ZASP, FLNC, or BAG3 genes and characterized by disintegration of myofibrils and accumulation of degradation products into intracellular inclusions.
|
21676617 |
2011 |
Myofibrillar Myopathy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Most of them were identified, as expected, on TTN (29 DCM probands), but truncating variants were also identified on myofibrillar myopathies causing genes in 17 DCM patients (7.7% of the DCM cohort): 10 variations on FLNC and 7 variations on BAG3 .
|
28436997 |
2017 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
BEFREE |
This report confirms the association of giant axonal neuropathy with BAG3-associated myofibrillar myopathy, and highlights that neuropathy may be a significant feature.
|
22734908 |
2012 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
BAG3-related MFM is particularly severe, featuring weakness, cardiomyopathy, neuropathy, and early lethality.
|
25728519 |
2015 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
BEFREE |
BAG3-related MFM is particularly severe, featuring weakness, cardiomyopathy, neuropathy, and early lethality.
|
25728519 |
2015 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
A homozygous disruption or genetic mutation of the bag3 gene, a member of the Bcl-2-associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is characterized by myofibril and Z-disc disruption.
|
20884878 |
2010 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
BEFREE |
BAG3-related myofibrillar myopathy in a Chinese family.
|
21361913 |
2012 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Further, we show that DNAJB6 interacts with members of the CASA complex, including the myofibrillar myopathy-causing protein BAG3.
|
22366786 |
2012 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
BEFREE |
However, we now demonstrate that patients can develop a myopathy with histologic features of myofibrillar myopathy with aggregates and rimmed vacuoles, similar to the pathology in myopathies due to gene defects in other compounds of the CASA complex such as BAG3 and DNAJB6 after developing the early neurogenic effects.
|
26718575 |
2016 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome.
|
26545904 |
2015 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A homozygous disruption or genetic mutation of the bag3 gene, a member of the Bcl-2-associated athanogene (BAG) family proteins, causes cardiomyopathy and myofibrillar myopathy that is characterized by myofibril and Z-disc disruption.
|
20884878 |
2010 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
Interestingly, we detected a polyneuropathy in 28% of the MFM patients, including a BAG3 and a MYOT case, and hearing impairment in 13%, including one patient with a FLNC mutation and two with mutations in the DES gene.
|
25208129 |
2014 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
BAG3 deficiency results in fulminant myopathy and early lethality.
|
16936253 |
2006 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
To our knowledge this is the first study reporting, in a BAG3 MFM, the simultaneous presence of genetic variants in the BAG3 and FHL1 genes (previously described as independently associated with MFMs) and linking the NRAP gene to MFM for the first time.
|
27443559 |
2016 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
These observations suggest that the BAG3 variant of myofibrillar myopathy may result from a spontaneous mutation at an early point of embryonic development and that transmission from a mosaic parent may occur more than once.
|
20605452 |
2010 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
This report confirms the association of giant axonal neuropathy with BAG3-associated myofibrillar myopathy, and highlights that neuropathy may be a significant feature.
|
22734908 |
2012 |
Myofibrillar Myopathy
|
0.800 |
Biomarker
|
disease |
CLINGEN |
We therefore searched for mutations in BAG3 in 53 unrelated MFM patients.
|
19085932 |
2009 |