Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that normal colocytes featured a strong ENTPD5 cytoplasmic expression whereas a significantly and progressively lower expression was present along with dedifferentiation of the histologic phenotype.
|
25115394 |
2014 |
Apocrine metaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results obtained from the immunohistochemical study showed that PCPH was undetectable in samples of normal breast and of benign diseases, with the exception of glands presenting apocrine metaplasia, in which an intense PCPH stain was observed both in the basal cytoplasm of the secretory cells and in the apocrine secretion.
|
15375529 |
2004 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our results strengthen the hypothesis of a central role of miR-182 dysregulation in colon mucosa transformation, demonstrate the concomitant progressive down-regulation of ENTPD5 levels during colon carcinogenesis, and indicate the potential of circulating miR-182 as blood based biomarker for screening and monitoring CRC during the follow-up.
|
25115394 |
2014 |
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Results showed that this experimental system is relevant to human breast carcinogenesis and provides an excellent model to study the molecular basis of the regulation of PCPH expression during normal differentiation and pathologic stages of neoplasia of the mammary gland and to analyze the role of PCPH in the carcinogenic process.
|
11933075 |
2002 |
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These results were in agreement with those from the immunohistochemical study and together indicated that PCPH protein expression represents a good molecular marker to follow the process of human breast carcinogenesis.
|
15375529 |
2004 |
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
This trend toward loss of PCPH expression along malignant progression of the larynx was confirmed by the low to null expression of PCPH in samples of invasive laryngeal carcinoma and by the complete absence of PCPH immunostaining in a laryngeal carcinoma-derived liver metastasis.
|
12489110 |
2002 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens.
|
25794010 |
2015 |
COENZYME Q10 DEFICIENCY, PRIMARY, 6
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency.
|
24140869 |
2014 |
COENZYME Q10 DEFICIENCY, PRIMARY, 6
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.
|
21540551 |
2011 |
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among them, three continuously down-regulated (MAOA, ENTPD5, and MOSC2) and one continuously overexpressed (COL12A1) are reported, to our best knowledge, for the first time in a connection to colon cancer onset.
|
21061036 |
2011 |
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results from experiments designed to test such hypothesis demonstrate that, as expected, mt-PCPH expression in human colorectal carcinoma (CRC) cells decreased their ATP levels and conferred resistance to oxaliplatin, a colorectal cancer-relevant chemotherapeutic agent.
|
23921441 |
2013 |
Dysplasia of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicated that PCPH protein analysis might allow for the distinction between grades of laryngeal dysplasia.
|
12489110 |
2002 |
Germ cell tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PCPH expression is an early event in the development of testicular germ cell tumors.
|
16465363 |
2006 |
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Additionally, an upregulation of ENTPD5 in both GBM mouse xenografts and in GBM patient tumors was identified, resulting in dramatically reduced survival.
|
22992974 |
2012 |
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) has been shown to be important in maintaining cellular function in cancer, and its expression is upregulated through multiple, unique pathways in certain cancers, including laryngeal, glioblastoma multiforme, breast, testicular, and prostate.
|
31242188 |
2019 |
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Additionally, an upregulation of ENTPD5 in both GBM mouse xenografts and in GBM patient tumors was identified, resulting in dramatically reduced survival.
|
22992974 |
2012 |
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) has been shown to be important in maintaining cellular function in cancer, and its expression is upregulated through multiple, unique pathways in certain cancers, including laryngeal, glioblastoma multiforme, breast, testicular, and prostate.
|
31242188 |
2019 |
Laryngeal Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This trend toward loss of PCPH expression along malignant progression of the larynx was confirmed by the low to null expression of PCPH in samples of invasive laryngeal carcinoma and by the complete absence of PCPH immunostaining in a laryngeal carcinoma-derived liver metastasis.
|
12489110 |
2002 |
Laryngeal neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia.
|
12489110 |
2002 |
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, detection of altered PCPH polypeptides by Western analysis potentially can be applied to the early identification of laryngeal squamous cell carcinoma.
|
12489110 |
2002 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, these results suggested that characterization of the pattern and level of PCPH expression may be a useful tool for early identification of breast cancers.
|
15375529 |
2004 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results from experiments designed to test such hypothesis demonstrate that, as expected, mt-PCPH expression in human colorectal carcinoma (CRC) cells decreased their ATP levels and conferred resistance to oxaliplatin, a colorectal cancer-relevant chemotherapeutic agent.
|
23921441 |
2013 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens.
|
25794010 |
2015 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, we described that the PCPH protein becomes highly expressed in human prostatic intraepithelial neoplasia and in PCa, and that the functional interaction between PCPH and protein kinase Cdelta (PKCdelta) increases the invasiveness of human PCa.
|
19117992 |
2009 |