|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The CD40 receptor and its ligand (CD40L) are known to modulate both inflammation and thrombosis-2 processes important for the development and clinical expression of atherosclerosis.
|
19061720 |
2008 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
A role for platelet CD40L in mediating thrombotic and inflammatory processes in atherosclerosis has also been reported.
|
24030045 |
2014 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Increasing evidence shows that CD40-CD40L interaction plays a crucial role in the pathogenesis of atherosclerosis and coronary artery disease.
|
14687897 |
2004 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The recent recognition of platelets as an abundant source of CD40L led to a reassessment of the involvement of CD40L in atherosclerosis.
|
14517846 |
2003 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Biomarkers of endothelial dysfunction such as endoglin (in the control group: 3.85+/-1.25 microg/l, in lipoprotein apheresis-treated hypercholesterolemic individuals 5.74+/-1.47 microg/l), CD40 ligand (before lipoprotein apheresis: 6498+/-2529 ng/l, after lipoprotein apheresis: 4057+/-2560 ng/l) and neopterin (before lipoprotein apheresis: 5.7+/-1.1 nmol/l, after lipoprotein apheresis: 5.5+/-1.3 nmol/l) related to the course of atherosclerosis, but did not reflect the actual activity of the disease nor facilitate the prediction or planning of therapy.
|
28379034 |
2017 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Indeed, blockade of CD40L by neutralizing antibodies or genetic disruption in mice prevents atherosclerosis and atherothrombosis.
|
26719354 |
2017 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and inflammation during atherosclerosis.
|
24664276 |
2014 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The interaction between CD40 and its ligand (CD40L) has been implicated in the pathogenesis of atherosclerosis and is recognized as a central event in the development of immuno-inflammatory processes.
|
19187784 |
2009 |
|
Atherosclerosis
|
0.300 |
Therapeutic
|
disease |
RGD |
Regression analysis revealed that the predictor of atherosclerosis was CD40L.
|
23984971 |
2013 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we illustrate the various functional features of these molecules, while describing the increasingly important role of CD40 in CD154-associated vascular pathologies such as atherosclerosis and atherothrombosis.
|
19282242 |
2009 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis.
|
9050882 |
1997 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence implicate CD40 ligand (CD40L, CD154) as a mediator and marker of atherosclerosis.
|
17332487 |
2007 |