|
Malignant neoplasm of prostate
|
0.090 |
Biomarker
|
disease |
BEFREE |
It was demonstrated that ETV2 forms complexes with two histone demethylases: Jumonji domain‑containing (JMJD)2A and JMJD2D; JMJD2A has been previously reported as a driver of prostate cancer development.
|
29393482 |
2018 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
It was demonstrated that ETV2 forms complexes with two histone demethylases: Jumonji domain‑containing (JMJD)2A and JMJD2D; JMJD2A has been previously reported as a driver of prostate cancer development.
|
29393482 |
2018 |
|
Malignant neoplasm of prostate
|
0.090 |
Biomarker
|
disease |
BEFREE |
By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate cancer (PCa).
|
28346812 |
2017 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Jumonji C domain 2A (JMJD2A), as a histone demethylases, plays a vital role in tumorigenesis and progression.
|
28693517 |
2017 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The critical role of lysine demethylase 4A (KDM4A), in regulating chromatin structure and consequently in driving cellular proliferation and oncogenesis has been the focus of recent studies.
|
28059867 |
2017 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate cancer (PCa).
|
28346812 |
2017 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Loss of KDM4A in hypoxic conditions leads to a decreased HIF-1α mediated transcriptional response and correlates with a reduction in the characteristics associated with tumour aggressiveness, including invasion, migration, and oxygen consumption.
|
28894274 |
2017 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
We also evaluated the impacts of JMJD2A-lactate dehydrogenase A (LDHA) signaling on NPC cell proliferation, migration and invasion.
|
28693517 |
2017 |
|
Malignant neoplasm of prostate
|
0.090 |
Biomarker
|
disease |
BEFREE |
As Jmjd2a is a histone demethylase, in the current study, we investigated the relationship between interaction Lgr4 with Jmjd 2a and Jmjd2a/androgen receptor (AR) signaling pathway in PCa progression.
|
27743893 |
2016 |
|
Malignant neoplasm of prostate
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
ETV1 facilitated the recruitment of JMJD2A to the YAP1 promoter, leading to changes in histone lysine methylation in a human prostate cancer cell line.
|
26731476 |
2016 |
|
Malignant neoplasm of prostate
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results suggest that KDM4A is a key regulator of tumor metabolism and a potential therapeutic target for prostate cancer.
|
27626669 |
2016 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
The histone lysine demethylase KDM4A/JMJD2A has been implicated in prostate carcinogenesis through its role in transcriptional regulation.
|
27626669 |
2016 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
|
26731476 |
2016 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have shown that the Jumonji domain containing 2A (JMJD2A) was aberrantly expressed in various tumors and involved in the regulation of tumor progression, but the role of JMJD2A on the tumorigenesis in NSCLC and the underlying mechanisms are still unclear.
|
26498874 |
2016 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these results elucidated a novel mechanism - ERG promotes prostate tumorigenesis together with KDM4A through the upregulation of YAP1.
|
27109047 |
2016 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
As Jmjd2a is a histone demethylase, in the current study, we investigated the relationship between interaction Lgr4 with Jmjd 2a and Jmjd2a/androgen receptor (AR) signaling pathway in PCa progression.
|
27743893 |
2016 |
|
Prostate carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
ETV1 facilitated the recruitment of JMJD2A to the YAP1 promoter, leading to changes in histone lysine methylation in a human prostate cancer cell line.
|
26731476 |
2016 |
|
Prostate carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results suggest that KDM4A is a key regulator of tumor metabolism and a potential therapeutic target for prostate cancer.
|
27626669 |
2016 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Further studies demonstrated that after pretreatment with 3-MA (3 mmol/L) for 48 h, siKDM4A-transfected cells showed a prominent decrease in LC3B-II/LC3B-I and Beclin 1, accompanied by increased viability and invasion and decreased apoptosis.
|
27514525 |
2016 |
|
Malignant neoplasm of prostate
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Histone lysine demethylase KDM4/JMJD2s are overexpressed in many human tumors including prostate cancer (PCa).
|
26364928 |
2015 |
|
Prostate carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Histone lysine demethylase KDM4/JMJD2s are overexpressed in many human tumors including prostate cancer (PCa).
|
26364928 |
2015 |
|
Tumor Cell Invasion
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
We previously identified Jumonji domain containing 2A (JMJD2A) as a critical mediator of breast cancer proliferation, migration and invasion.
|
24886710 |
2014 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulation of JMJD2A led to reduced endometrial carcinoma RL95-2 and ISK cell proliferation, invasion and metastasis as asessed with cell counting kit-8, cell migration and invasive assays.
|
24815446 |
2014 |
|
Malignant neoplasm of prostate
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We correlated LSD1 and JMJD2A expression with known mediators of prostate cancer progression: VEGF-A and cyclin A1.
|
23384557 |
2013 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Various human cancers exhibit elevated protein levels of KDM4A-D members, and their depletion impairs tumor formation, suggesting that their enhanced activity promotes carcinogenesis.
|
23589305 |
2013 |