Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Twenty-four nonmonomorphic genetic variants of UBE3C were genotyped in 163 patients with AIA and 429 controls with aspirin-tolerant asthma.
|
20934631 |
2010 |
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics and may contribute novel insights into the clinical relevance and potential involvement of UBE3C in respiratory deficiencies.
|
21881582 |
2011 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
UBE3C expression was increased in ccRCC tissues compared with adjacent normal tissues. ccRCC patients with high UBE3C protein expression in tumors were associated with significantly worse postoperative survival.
|
25658088 |
2015 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Mechanistically, we disclosed that UBE3C physically interacted with and ubiquitinated tumor suppressor gene annexin A7 (ANXA7), resulting in ubiquitination and degradation of ANXA7.
|
26067607 |
2015 |
Recurrent tumor
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Clinically, UBE3C overexpression significantly correlated with high-grade tumors (p < 0.05), poor overall survival, and early tumor recurrence.
|
26067607 |
2015 |
Recurrent tumor
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Clinically, a tissue microarray study of a cohort containing 323 HCC patients revealed that the overexpression of UBE3C in primary HCC tissues correlated with decreased survival (hazard ratio [HR] =1.657, 95% confidence interval [CI] =1.220-2.251, P=0.001) and early tumor recurrence (HR=1.653, 95% CI=1.227-2.228, P=0.001) in postoperative HCC patients.
|
24425307 |
2014 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells.
|
27862841 |
2017 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, the inhibition of ANXA7 expression in gliomas cells with UBE3C interference could rescue the cell invasion.
|
26067607 |
2015 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that UBE3C is a candidate oncogene involved in tumor development and progression and therefore a potential therapeutic target in applicable HCC patients.
|
24425307 |
2014 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In clinical samples of HCC, miR-542-3p inversely correlated with UBE3C, which was upregulated in HCC.
|
28666208 |
2017 |
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, UBE3C_ht1 was found to be consistently associated with nasal polyps in the overall asthmatics group (P=0.006) and the ATA phenotype (P=0.002; P(corr)=0.02) via a codominant mechanism.
|
21881582 |
2011 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Correlation analysis indicated that expression of miR-30a-5p was highly negatively correlated with UBE3C, which was upregulated in BC specimens.
|
27003255 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of UBE3C reduced NSCLC stemness and tumorigenesis both in vivo and in vitro.
|
30503554 |
2019 |
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these observations suggest that UBE3C plays an important role in RCC development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC.
|
25658088 |
2015 |
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, our data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7, and thus presents a novel and promising target for glioma therapy.
|
26067607 |
2015 |
Nasal Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics and may contribute novel insights into the clinical relevance and potential involvement of UBE3C in respiratory deficiencies.
|
21881582 |
2011 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this report, we for the first time demonstrated ubiquitin protein ligase E3C (UBE3C) as a driving factor for RCC growth and metastasis.
|
25658088 |
2015 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these observations suggest that UBE3C plays an important role in RCC development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC.
|
25658088 |
2015 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of UBE3C reduced NSCLC stemness and tumorigenesis both in vivo and in vitro.
|
30503554 |
2019 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Correlation analysis indicated that expression of miR-30a-5p was highly negatively correlated with UBE3C, which was upregulated in BC specimens.
|
27003255 |
2019 |
Juvenile-Onset Still Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets.
|
19565504 |
2009 |
Juvenile arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets.
|
19565504 |
2009 |
Juvenile psoriatic arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets.
|
19565504 |
2009 |
Polyarthritis, Juvenile, Rheumatoid Factor Negative
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets.
|
19565504 |
2009 |
Polyarthritis, Juvenile, Rheumatoid Factor Positive
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets.
|
19565504 |
2009 |