Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
NOS1AP is encoded by a gene recently associated with sudden cardiac death, diabetes-associated complications, and schizophrenia (Arking et al., 2006; Becker et al., 2008; Brzustowicz, 2008; Lehtinen et al., 2008).
|
23658158 |
2013 |
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
NOS1AP mRNA and serum levels were significantly elevated in SCZ patients (p<0.001; p<0.001) compared with healthy control.
|
29100974 |
2018 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Amongst the most promising candidate molecules for schizophrenia are neuronal nitric oxide (NO) synthase (NOS-I, also known as nNOS) and its adapter protein NOS1AP (previously named CAPON).
|
26861996 |
2016 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
An increasing body of evidence is pointing to the significant roles of NOS1AP in excitotoxic neuronal damage, traumatic nervous system injury, bipolar disorder, and schizophrenia.
|
27237129 |
2016 |
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
As NOS1AP is overexpressed in the cortex of patients with SCZ and negatively regulates NMDAR signaling, we subsequently examined whether treatment with antipsychotics or NMDAR agonists can reverse the detrimental effects of NOS1AP overexpression in vitro as previously reported by our group.
|
29601869 |
2018 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four of these 9 "risk ROHs" contained or neighbored genes associated with SCZ (NOS1AP, ATF2, NSF, and PIK3C3).
|
18077426 |
2007 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
|
23212062 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Identification of a schizophrenia-associated functional noncoding variant in NOS1AP.
|
19255043 |
2009 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted.
|
18474209 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted.
|
18474209 |
2008 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
LHGDN |
Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder.
|
16146415 |
2005 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3).
|
19451863 |
2009 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder.
|
19077434 |
2009 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
LHGDN |
Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder.
|
19077434 |
2009 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the potential importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia.
|
15707951 |
2005 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the potential importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia.
|
15707951 |
2005 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia.
|
18430503 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia.
|
18430503 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males.
|
26384012 |
2015 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The finding of allelic association with markers in the UHMK1 gene might help explain why it has not been possible, despite great effort, to satisfactorily confirm previously reported associations between schizophrenia and the genes RGS4 and NOS1AP/CAPON.
|
18414510 |
2008 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia.
|
24220657 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia.
|
24220657 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
|
16202394 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
|
16202394 |
2006 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results were similar after adjusting for the NOS1AP risk genotype (adjusted OR=3.57, 95% CI=1.32, 9.65) and for maternal or paternal history of schizophrenia (adjusted ORs=3.27, 95% CI=1.45, 7.38; 4.38, 95% CI=1.61, 11.91, respectively).
|
20541371 |
2010 |