Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease LHGDN Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the potential importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia. 15707951 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the potential importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia. 15707951 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease LHGDN Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. 16146415 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease LHGDN The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations. 16202394 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations. 16202394 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Four of these 9 "risk ROHs" contained or neighbored genes associated with SCZ (NOS1AP, ATF2, NSF, and PIK3C3). 18077426 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE We detected positive allelic association after the eighth marker was genotyped and found that three microsatellite markers (p = .011, p = .014, p = .049) and two SNPs (p = .004, p = .043) localized in the 700 kb region between the RGS4 and CAPON genes, within the UHMK1 gene, were associated with schizophrenia. 16978587 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia. 18430503 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE The finding of allelic association with markers in the UHMK1 gene might help explain why it has not been possible, despite great effort, to satisfactorily confirm previously reported associations between schizophrenia and the genes RGS4 and NOS1AP/CAPON. 18414510 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease LHGDN Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia. 18430503 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted. 18474209 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease LHGDN In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted. 18474209 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder. 19077434 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease LHGDN Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder. 19077434 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3). 19451863 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. 19255043 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE The results were similar after adjusting for the NOS1AP risk genotype (adjusted OR=3.57, 95% CI=1.32, 9.65) and for maternal or paternal history of schizophrenia (adjusted ORs=3.27, 95% CI=1.45, 7.38; 4.38, 95% CI=1.61, 11.91, respectively). 20541371 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives. 20638248 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE We analyzed the coding sequence of NOS1AP in a large population (n = 280), including patients with schizophrenia (n = 72), ASD (n = 81) or OCD (n = 34), and in healthy volunteers controlled for the absence of personal or familial history of psychiatric disorders (n = 93). 20602773 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease PSYGENET We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives. 20638248 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease GWASDB Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. 23212062 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE NOS1AP is encoded by a gene recently associated with sudden cardiac death, diabetes-associated complications, and schizophrenia (Arking et al., 2006; Becker et al., 2008; Brzustowicz, 2008; Lehtinen et al., 2008). 23658158 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease PSYGENET The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia. 24220657 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia. 24220657 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males. 26384012 2015