|
Sick Sinus Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of Trx2 reduces HCN4 expression via a mitochondrial ROS-HDAC4-MEF2C pathway and subsequently induces sick sinus syndrome in mice.
|
31751569 |
2020 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In human colon polyps and adenocarcinomas, miR-22 and RARβ were consistently reduced, which was associated with elevated HDAC1, HDAC4, and SIRT1 in colon adenocarcinomas.
|
30252536 |
2019 |
|
Anxiety
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further, we found that overexpression of HDAC4 in the hippocampus improves anxiety, depressive-like behavior, and memory functions following TBI.
|
31169064 |
2019 |
|
Anxiety Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Further, we found that overexpression of HDAC4 in the hippocampus improves anxiety, depressive-like behavior, and memory functions following TBI.
|
31169064 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we reveal miR-138 regulates RA-related inflammatory cytokines in rheumatoid arthritis through HDAC4/PGRN or HDAC4/NF-κB.
|
31492495 |
2019 |
|
Mental disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Histone Deacetylase 4 Downregulation Elicits Post-Traumatic Psychiatric Disorders through Impairment of Neurogenesis.
|
31169064 |
2019 |
|
Carpal Tunnel Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An Agilent miRNA microarray was used to profile miRNAs in the CTS-treated BMSCs and 3D-cultured control BMSCs. miR-365 was shown to interact with HDAC4 mRNA through a luciferase reporter assay.
|
31276691 |
2019 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We discovered three HDAC4 mutations (p.His227Arg, p.Asp234Asn, and p.Glu374Lys) in unrelated individuals who had nonautoimmune diabetes with various degrees of β-cell loss.
|
30968599 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
HDAC4-knockout mice develop heart failure in models of type 1 and type 2 diabetes mellitus, whereas wild-type mice do not develop clear signs of heart failure, indicating that HDAC4 protects the diabetic heart.
|
31195810 |
2019 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
After injection of si-HDAC4, the epilepsy rats presented with a reduction in seizure degree, latency and duration of seizure, amount of scattered epileptic waves, and occurrence of epilepsy, with an improvement in their cognitive function.
|
30787615 |
2019 |
|
External exotoses
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of HDAC4 reduced osteophyte formation and cartilage damage, and increased articular cartilage anabolism.
|
31310910 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we looked for association between serum HDAC4 and DLCOsb (Single-breath diffusing capacity of the lung for carbon monoxide), as % of predicted by age, height, and gender, one of the main differences described between COPD-BS and COPD-TS.
|
31817742 |
2019 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
HDAC4 inhibition could be a potential alternative to prevent MKK7/JNK/c-Jun axis-mediated nervous disorders, including SAH-caused EBI.
|
31708743 |
2019 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of HDAC4 attenuated the effects of miR-206-3p on neuropathic pain.
|
30587671 |
2019 |
|
Cartilaginous exostosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Methods:</b> The levels of HDAC4 and PCNA mRNA and protein were tested in human OS and osteochondroma (OC) tissues.
|
31552187 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7.
|
31708743 |
2019 |
|
Gestational Diabetes
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Enhanced AMPK activation, accompanied with decreased HDAC4 and G6Pase expression (p < 0.05) were partly contributed to the alleviation of GD mediated by curcumin.
|
30957612 |
2019 |
|
Complete atrioventricular block
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we observed a negative correlation between the expression of miRNA-548ah and HDAC4 in the liver tissue of patients with CHB.
|
30615846 |
2019 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggest that selectively targeting class IIa HDAC isoforms (in particular HDAC4) may inhibit development and progression of renal fibrosis by suppressing activation and expression of multiple profibrotic molecules and increasing expression of antifibrotic proteins and MMPs.-Xiong, C., Guan, Y., Zhou, X., Liu, L., Zhuang, M. A., Zhang, W., Zhang, Y., Masucci, M. V., Bayliss, G., Zhao, T. C., Zhuang, S. Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis.
|
30951378 |
2019 |
|
Uveal melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Similarly, BAP1-deficient uveal melanoma cells are preferentially vulnerable to HDAC4 depletion.
|
31555735 |
2019 |
|
Atrophy, Disuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data indicated that a single bout of preconditioning exercise prior to HU may exert a protective effect in disuse muscle atrophy in old rats and that these effects may be partially mediated by the HDAC4/Gadd45α axis.
|
31009659 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further in vivo experiments identified that Catalpol alleviated myocardial damage by regulating Neat1/miR-140-5p/HDAC4 axis in DCM mice.
|
31078585 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
We determined that the HDAC1/2/3 inhibitor Mocetinostat synergizes with the HDAC4/5/6 inhibitor LMK-235 in a panel of PDAC cell lines.
|
31500290 |
2019 |
|
Osteophyte
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of HDAC4 reduced osteophyte formation and cartilage damage, and increased articular cartilage anabolism.
|
31310910 |
2019 |
|
Pediatric Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In total, 26 probes were associated (<i>p</i> < 0.05) with changes in BMI z-score overall, including probes within Mesoderm Specific Transcript <i>(MEST)</i> and Histone Deacetylase 4 (<i>HDAC4</i>), which have previously been associated with childhood obesity and adipogenesis.
|
31216936 |
2019 |