|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Depletion of ARK5 prolongs survival in MYC-driven mouse models of hepatocellular carcinoma, demonstrating that targeting cellular energy homeostasis is a valid therapeutic strategy to eliminate tumour cells that express deregulated MYC.
|
22460906 |
2012 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.
|
26213588 |
2015 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma.
|
26873845 |
2016 |
|
Hypocalcemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
From these data, the following 5 genes were selected as being strongly related to both experimental hypocalcemia and milk fever: protein kinase (cAMP-dependent, catalytic) inhibitor β (PKIB); DNA-damage-inducible transcript 4 (DDIT4); period homolog 1 (PER1); NUAK family, SNF1-like kinase, 1 (NUAK1); and expressed sequence tag (BI537947).
|
24210493 |
2014 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ARK5 is found to play a role in ICC metastasis and regulating EMT.
|
31360102 |
2019 |
|
Nasopharyngeal carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, according to survival analysis, there was clinical relevance between the upregulation of NUAK1 in NPC and DFS.
|
30121842 |
2018 |
|
Metastatic melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we have identified NUAK1 as a potential target for the treatment of metastatic melanoma.
|
23934065 |
2014 |
|
Pervasive Development Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice.
|
30327473 |
2018 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice.
|
30327473 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the role of ARK5 in invasion and metastasis of HCC cells remains unclear.
|
29434843 |
2018 |
|
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
|
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
|
Childhood Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
|
Plasmacytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry staining showed that the expression of NUAK1 correlated with the differentiation and stage of the carcinoma, as well as with lymph node metastasis.
|
23215946 |
2013 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, NUAK1 expression was well correlated with poor differentiation, invasiveness, and lymph node metastasis in HNSCC cases.
|
26882562 |
2016 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
In an in vivo study, we also demonstrated that ARK5-transfected breast cancer cells grew faster and had more pulmonary metastases than its parental counterparts.
|
22105900 |
2012 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In an in vivo study, we also demonstrated that ARK5-transfected breast cancer cells grew faster and had more pulmonary metastases than its parental counterparts.
|
22105900 |
2012 |
|
Secondary malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
In an in vivo study, we also demonstrated that ARK5-transfected breast cancer cells grew faster and had more pulmonary metastases than its parental counterparts.
|
22105900 |
2012 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we examined the role of ARK5 in ovarian cancer and normal matched tissues using western blot analysis and migration and invasion, and wound‑healing assays.
|
26151663 |
2015 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, we attempted to determine whether ARK5 is involved in tumor malignancy under regulation by Akt.
|
15060171 |
2004 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, we attempted to determine whether ARK5 is involved in tumor malignancy under regulation by Akt.
|
15060171 |
2004 |
|
Secondary malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
In vivo genetic reconstitution experiments show that miR-203 inhibits lung metastasis by suppressing the prometastatic activities of three factors involved in cytoskeletal dynamics (LASP1), extracellular matrix remodeling (SPARC), and cell metabolism (NUAK1).
|
25284788 |
2014 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of ARK5 was able to significantly reduce the ability HCC cells to invade and metastasize.
|
29434843 |
2018 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of miR-211 increases NUAK1 expression and decreases melanoma adhesion, whereas upregulation of miR-211 restores adhesion through NUAK1 repression.
|
23934065 |
2014 |