|
Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcription factor MafB regulates differentiation and activity of monocytes/macrophage and is associated with the development of atherosclerosis and cancers.
|
31447817 |
2019 |
|
Atherosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcription factor MafB regulates differentiation and activity of monocytes/macrophage and is associated with the development of atherosclerosis and cancers.
|
31447817 |
2019 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development.
|
30485546 |
2019 |
|
Osteoporosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because miR-338-3p is crucial for osteoclastic differentiation via targeting of the transcription factor MafB, inhibition of this miRNA represents a potential strategy for modulating osteoporosis in an aging population.
|
30716449 |
2019 |
|
Hepatitis C, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcription Factor MafB Suppresses Type I Interferon Production by CD14<sup>+</sup> Monocytes in Patients With Chronic Hepatitis C.
|
31447817 |
2019 |
|
Focal glomerulosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome.
|
29779709 |
2018 |
|
Hyperparathyroidism, Secondary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcription factor MafB may play an important role in secondary hyperparathyroidism.
|
28964572 |
2018 |
|
Hypospadias
|
0.010 |
Biomarker
|
disease |
BEFREE |
Androgen-induced genes, such as MAFB, which belongs to the activator protein 1 (AP-1) superfamily of genes, have essential roles in male urethral formation, and disruption of its signalling can interfere with urethral formation, which often results in hypospadias.
|
29670181 |
2018 |
|
Penile hypospadias
|
0.010 |
Biomarker
|
disease |
BEFREE |
Androgen-induced genes, such as MAFB, which belongs to the activator protein 1 (AP-1) superfamily of genes, have essential roles in male urethral formation, and disruption of its signalling can interfere with urethral formation, which often results in hypospadias.
|
29670181 |
2018 |
|
Leukemogenesis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In mouse models of T-ALL, MAFB enhanced leukemogenesis by the naturally occurring Notch1 mutants, decreased disease latency, and increased disease penetrance.
|
29138297 |
2017 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, these data identify a mechanism for enhancing the oncogenic potential of weak Notch1 mutants in leukemia models, and they reveal the MAFB-ETS2 transcriptional axis as a potential therapeutic target in T-ALL.
|
29138297 |
2017 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcription Factor MafB Promotes Hepatocellular Carcinoma Cell Proliferation through Up-Regulation of Cyclin D1.
|
27448450 |
2016 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case-control study.
|
26204962 |
2015 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case-control study.
|
26204962 |
2015 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts.
|
25721756 |
2015 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
To assess potential effects of variants in six lipid modulating genes (SORT1, HMGCR, MLXIPL, FADS2, APOE and MAFB) on early development of dyslipidemia independent of the degree of obesity in children, we investigated their association with total (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) cholesterol and triglyceride (TG) levels in 594 children.
|
26375028 |
2015 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We found that migration and invasion abilities were inhibited by MAFB silencing.
|
26055874 |
2015 |
|
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case-control study.
|
26204962 |
2015 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells.
|
26055874 |
2015 |
|
Trichohepatoenteric Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To further assess its role in NSCLP, we investigated 3 identified single nucleotide polymorphisms in MAFB (rs13041247, rs6065259, and rs11696257) and examined them for association with NSCLP in 344 patients and 324 healthy controls in a northern Chinese Han population with a high incidence of the syndrome.
|
24972815 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet β cell function, with loss of MAFA (and/or MAFB) representing an early indicator of β cell inactivity and the subsequent deficit of more impactful NKX6.1 (and/or PDX1) resulting in overt dysfunction associated with T2DM.
|
23863625 |
2013 |
|
Fibrosarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recently, mutations in a highly conserved region of the MAFB gene (v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B) have been identified in MCTO patients by exome sequencing.
|
23956186 |
2013 |
|
Adult Fibrosarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recently, mutations in a highly conserved region of the MAFB gene (v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B) have been identified in MCTO patients by exome sequencing.
|
23956186 |
2013 |
|
Tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although the locus is located in inter-genic region, the nearest genes (HSPEP1-MAFB) from this locus are promising candidates for TB susceptibility.
|
22551897 |
2012 |
|
Cleft palate, isolated
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance.
|
20436469 |
2010 |