Schizophrenia
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In order to determine whether the mRNA expression levels of Cdc42, Rac1, RhoA, Duo or drebrin are altered in schizophrenia, tissue sections containing DLPFC area 9 from 15 matched pairs of subjects with schizophrenia and control subjects were processed for in situ hybridization.
|
16402129 |
2006 |
Schizophrenia
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
The expression of CDC42 (cell division cycle 42), a RhoGTPase that regulates the outgrowth of the actin cytoskeleton and promotes spine formation, is also lower in schizophrenia; however, CDC42 mRNA is lower across layers 3-6, suggesting that other lamina-specific molecular alterations are critical for the spine deficits in the illness.
|
20385374 |
2010 |
Schizophrenia
|
0.350 |
Biomarker
|
disease |
PSYGENET |
The expression of each of these mRNAs was lower in the gray matter of the subjects with schizophrenia compared to the control subjects, although only the reductions in Cdc42 and Duo remained significant after corrections for multiple comparisons.
|
16402129 |
2006 |
Schizophrenia
|
0.350 |
Biomarker
|
disease |
PSYGENET |
These results imply that subchronic MK-801 administration during adolescence might disturb the expression of RhoA, Rac1 and Cdc42 mRNA, and then lead to the decay of the spines in hippocampus, which could be involved in cognitive impairments in schizophrenia.
|
23747234 |
2013 |
Schizophrenia
|
0.350 |
Biomarker
|
disease |
BEFREE |
This study reveals a new role of ZDHHC8-cdc42-palm molecular pathway in postsynaptic structural plasticity and provides new evidence in favor of the dysconnectivity hypothesis for schizophrenia.
|
27365300 |
2017 |
Schizophrenia
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Using laser microdissection, samples of DLPFC deep layer 3 were collected from 56 matched pairs of subjects with schizophrenia and comparison subjects, and levels of CDC42-PAK-LIMK pathway messenger RNAs were measured by quantitative polymerase chain reaction.
|
25981171 |
2015 |
Schizophrenia
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We found evidence that rs2473307, in strong LD with the schizophrenia associated SNP rs2473277, is a functional variant at CDC42 that may increase risk for schizophrenia by reducing expression of CDC42.
|
22385474 |
2012 |
Schizophrenia
|
0.350 |
Biomarker
|
disease |
PSYGENET |
We found evidence that rs2473307, in strong LD with the schizophrenia associated SNP rs2473277, is a functional variant at CDC42 that may increase risk for schizophrenia by reducing expression of CDC42.
|
22385474 |
2012 |
Schizophrenia
|
0.350 |
Biomarker
|
disease |
PSYGENET |
We measured transcript levels of CDC42, CDC42EP3, CDC42EP4; their interacting proteins (septins [SEPT2, 3, 5, 6, 7, 8, and 11], anillin), and other spine-specific proteins (spinophilin, PSD-95, and synaptopodin) in the DLPFC from 31 subjects with schizophrenia and matched normal comparison subjects.
|
20385374 |
2010 |