|
Flexion limitation of toes
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analyses indicated that a high expression of hnRNP AB was significantly associated with preoperative carcinoembryonic antigen (CEA; P<0.001) and carbohydrate antigen 19-9 (P=0.014) levels, tumour size (P=0.022) and infiltration (P=0.026), lymph node metastasis (P<0.001) and Tumour-Node-Metastasis stage (P<0.001).
|
31819776 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
HNRPDL-overexpressing NIH-3T3 cells generated tumors in nude mice but not the control cells.
|
30052712 |
2018 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.
|
28315432 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
HnRNP Q1/ΔRBD23-truncated mutant, which loses the binding ability and translational regulation of Aurora-A mRNA, has no effect on promoting tumor growth.
|
28079881 |
2017 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
These data thus indicate that hnRNP A18 can promote tumor growth in in vivo models by coordinating the translation of pro-survival transcripts to support the demands of proliferating cells and increase survival under cellular stress. hnRNP A18 therefore represents a new target to selectively inhibit protein translation in tumor cells.
|
26824423 |
2016 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The Warburg effect is a well-recognized hallmark of cancer energy metabolism, and is regulated by the mTOR/c-Myc/hnRNP/PKM signaling cascade.
|
25644089 |
2015 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The analysis of hnRNP transcriptional responses considering the changing nature of the tumor microenvironment is important to understand tumor cell survival under stress conditions.
|
24246049 |
2014 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
We show that the splicing factors hnRNP A1 and hnRNP A2 are up-regulated in HCC tumors derived from inflammation-induced liver cancer mouse model.
|
24572810 |
2014 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The function of the RNA-binding protein hnRNP in cancer metastasis.
|
24516048 |
2013 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
This detection method was used to detect mRNA heterogeneous nuclear ribonucleoproteins (hnRNP B1) in two cancer cell lines, CL1-0 and CL1-5. hnRNP B1 is an mRNA biomarker that is overexpressed in lung cancer tissue in the early stage of cancer and can be found in the serum and plasma of lung cancer patients.
|
23511627 |
2013 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
These findings not only provide additional evidence that alternative splicing plays an important role in tumorigenesis, but also shed light on the molecular mechanism by which hnRNP proteins regulate cell proliferation in cancer.
|
20978194 |
2010 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
|
20010808 |
2010 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Nevertheless, in the majority of these cases, the identity of the regulators that control the expression of such cancer-related genes is poorly understood.In this issue of the JCI, Goehe et al. demonstrate that heterogeneous nuclear ribonuclear protein family member L (hnRNP L), a member of the hnRNP family of RNA processing factors, is specifically phosphorylated in non-small cell lung cancer (NSCLC).
|
20972326 |
2010 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells.
|
20190808 |
2010 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Human hnRNP genes have been reported to be involved in human malignancies and several hnRNPs are promising biomarkers of lung, head and neck, colon, breast, and pancreatic cancers.
|
17219427 |
2007 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Comparison between tumor probes and tumor-free specimens of NSCLC patients failed to approve the diagnostic relevance of hnRNP A2/B1 shown in previous studies, whereas hnRNP B1 revealed a high tumor specificity that could be helpful for tumor cell screening.
|
17067748 |
2006 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Our result might suggest that process of hnRNP B1 expression in ATLL differs from those in other lymphoid neoplasms and carcinoma.
|
12579305 |
2003 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
This paper briefly reviews four topics related to mechanisms of action of tea polyphenols: (I) identification of the genes commonly affected by EGCG, as demonstrated by Clontech's Atlas cDNA Expression Array; (II) the significance of heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) as a new biomarker for early detection of lung cancer, and inhibition of its expression by EGCG; (III) the synergistic or additive effects of EGCG with the cancer preventive agents, sulindac and tamoxifen, on induction of apoptosis in PC-9 cells and on inhibition of intestinal tumor development in multiple intestinal neoplasia (Min) mice; (IV) the results of a 10 year prospective cohort study demonstrating the effectiveness of daily consumption of green tea in preventing cancer, and a prototype study for developing green tea beverage as cancer preventive.
|
11506822 |
2001 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.
|
28315432 |
2017 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
The Warburg effect is a well-recognized hallmark of cancer energy metabolism, and is regulated by the mTOR/c-Myc/hnRNP/PKM signaling cascade.
|
25644089 |
2015 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
This detection method was used to detect mRNA heterogeneous nuclear ribonucleoproteins (hnRNP B1) in two cancer cell lines, CL1-0 and CL1-5. hnRNP B1 is an mRNA biomarker that is overexpressed in lung cancer tissue in the early stage of cancer and can be found in the serum and plasma of lung cancer patients.
|
23511627 |
2013 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
The function of the RNA-binding protein hnRNP in cancer metastasis.
|
24516048 |
2013 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
These findings not only provide additional evidence that alternative splicing plays an important role in tumorigenesis, but also shed light on the molecular mechanism by which hnRNP proteins regulate cell proliferation in cancer.
|
20978194 |
2010 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Nevertheless, in the majority of these cases, the identity of the regulators that control the expression of such cancer-related genes is poorly understood.In this issue of the JCI, Goehe et al. demonstrate that heterogeneous nuclear ribonuclear protein family member L (hnRNP L), a member of the hnRNP family of RNA processing factors, is specifically phosphorylated in non-small cell lung cancer (NSCLC).
|
20972326 |
2010 |