PDE10A, phosphodiesterase 10A, 10846

N. diseases: 97; N. variants: 26
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005586
Disease:
Bipolar Disorder
0.800 GeneticVariation GWASCAT Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005586
Disease:
Bipolar Disorder
0.800 GeneticVariation GWASDB Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0740858
Disease:
Substance abuse problem
0.010 GeneticVariation BEFREE Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0349204
Disease:
Nonorganic psychosis
0.010 GeneticVariation BEFREE Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1039002
rs1039002
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0033975
Disease:
Psychotic Disorders
0.010 GeneticVariation BEFREE Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951 2011
dbSNP: rs1079418
rs1079418
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0020676
Disease:
Hypothyroidism
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1079418
rs1079418
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0020676
Disease:
Hypothyroidism
0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
dbSNP: rs147212971
rs147212971
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0428883
Disease:
Diastolic blood pressure
T 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 28135244 2017
dbSNP: rs1554258695
rs1554258695
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310791
Disease:
STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2
C 0.700 CausalMutation CLINVAR
dbSNP: rs1554258695
rs1554258695
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C4310792
Disease:
DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET
C 0.700 GeneticVariation CLINVAR
dbSNP: rs221721
rs221721
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2934844
rs2934844
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005612
Disease:
Birth Weight
T 0.700 GeneticVariation GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
dbSNP: rs2934849
rs2934849
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0007222
Disease:
Cardiovascular Diseases
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2983511
rs2983511
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement
G 0.700 GeneticVariation GWASCAT Four loci previously associated with TSH in adults were confirmed in this study population (PDE10A (rs2983511: β = 0.112SD, p = 4.8 ∙ 10-16), FOXE1 (rs7847663: β = 0.223SD, p = 1.5 ∙ 10-20), NR3C2 (rs9968300: β = 0.194SD), p = 2.4 ∙ 10-11), VEGFA (rs2396083: β = 0.088SD, p = 2.2 ∙ 10-10)). 28333968 2017
dbSNP: rs2983514
rs2983514
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0020676
Disease:
Hypothyroidism
A 0.700 GeneticVariation GWASCAT Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. 30367059 2018
dbSNP: rs2983514
rs2983514
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0020550
Disease:
Hyperthyroidism
A 0.700 GeneticVariation GWASCAT Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. 30367059 2018
dbSNP: rs2983533
rs2983533
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0014772
Disease:
Red Blood Cell Count measurement
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs3002433
rs3002433
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs3008034
rs3008034
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement
C 0.700 GeneticVariation GWASCAT Whole-genome sequence-based analysis of thyroid function. 25743335 2015
dbSNP: rs3008034
rs3008034
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement
0.700 GeneticVariation GWASCAT A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents. 28333968 2017
dbSNP: rs4305701
rs4305701
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0014772
Disease:
Red Blood Cell Count measurement
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs650490
rs650490
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0678222
Disease:
Breast Carcinoma
0.010 GeneticVariation BEFREE Polymorphic variants of 2q35-rs13387042, 3p24-rs4973768, 17q23-rs650490 and FGFR2-rs2981578 were analyzed to test for their association with breast cancer susceptibility. 22287734 2012
dbSNP: rs650490
rs650490
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE Polymorphic variants of 2q35-rs13387042, 3p24-rs4973768, 17q23-rs650490 and FGFR2-rs2981578 were analyzed to test for their association with breast cancer susceptibility. 22287734 2012
dbSNP: rs6914479
rs6914479
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0014772
Disease:
Red Blood Cell Count measurement
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019