|
rs60571065
|
PPARGC1A
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined results of two datasets showed that two independent, potentially functional SNPs (i.e., HDAC2 rs13213007G>A and PPARGC1A rs60571065T>A) were significantly associated with NSCLC overall survival, with a combined hazards ratio (HR) of 1.26 (95% confidence interval (CI), 1.09-1.45; P = .002) and 1.23 (1.04-1.47; P = .017), respectively.
|
31713888 |
2020 |
|
rs2970847
|
PPARGC1A
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected the <i>PPARG</i> rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between <i>PPARG, PPARGC1A, PPARGC1B</i> their variants and risk of CRC.
|
30838172 |
2019 |
|
rs3736265
|
PPARGC1A
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected the <i>PPARG</i> rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between <i>PPARG, PPARGC1A, PPARGC1B</i> their variants and risk of CRC.
|
30838172 |
2019 |
|
rs777169839
|
PPARGC1A
|
Brain Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression of PGC-1α K224R mutant significantly increases mitochondrial biogenesis, reactive oxygen species (ROS) production, and tumor cell apoptosis under hypoxia and inhibits brain tumor growth in mice.
|
31629659 |
2019 |
|
rs777169839
|
PPARGC1A
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression of PGC-1α K224R mutant significantly increases mitochondrial biogenesis, reactive oxygen species (ROS) production, and tumor cell apoptosis under hypoxia and inhibits brain tumor growth in mice.
|
31629659 |
2019 |
|
rs8192678
|
PPARGC1A
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected the <i>PPARG</i> rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between <i>PPARG, PPARGC1A, PPARGC1B</i> their variants and risk of CRC.
|
30838172 |
2019 |
|
rs8192678
|
PPARGC1A
|
Angina, Unstable
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study we examined PPARA: rs4253778, rs1800206, PPARD: rs2267668, rs2016520, rs1053049, PPARG rs1801282 and PPARGC1A rs8192678 polymorphisms in patients with unstable angina.
|
31252163 |
2019 |
|
rs17574213
|
PPARGC1A
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs17574213 polymorphism was associated with obesity onset in children aged <1 years and 10-18 years.
|
29879371 |
2018 |
|
rs6821591
|
PPARGC1A
|
Motor symptoms
|
|
0.010 |
GeneticVariation |
BEFREE |
PPARGC1α rs6821591 was also associated with faster motor symptom progression as measured with the UPDRS-III (β = 0.234; p = 0.001).
|
29630901 |
2018 |
|
rs10212638
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs10517030
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs10517032
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that Koreans with the minor alleles of PGC-1α rs10517030, rs10517032 and rs10212638 are at greater risk of T2DM, and that a low-energy diet is more protective against the development of T2DM in subjects with the major alleles of rs10517030 and rs10517032.
|
28488691 |
2017 |
|
rs2970870
|
PPARGC1A
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
An association of cancer aggressiveness with rs2970870 of PPARGC1A, and rs501299 of ADIPOQ, as well as with one haplotype of ADIPOQ was documented.
|
28453464 |
2017 |
|
rs2970870
|
PPARGC1A
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
An association of cancer aggressiveness with rs2970870 of PPARGC1A, and rs501299 of ADIPOQ, as well as with one haplotype of ADIPOQ was documented.
|
28453464 |
2017 |
|
rs3774921
|
PPARGC1A
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the investigated polymorphisms, heterozygous carriers of rs3774921 in PPARGC1A showed a higher risk of colorectal cancer (OR [95% CI] = 1.26 [1.02-1.55] for TC vs. TT).
|
28051997 |
2017 |
|
rs3774921
|
PPARGC1A
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the investigated polymorphisms, heterozygous carriers of rs3774921 in PPARGC1A showed a higher risk of colorectal cancer (OR [95% CI] = 1.26 [1.02-1.55] for TC vs. TT).
|
28051997 |
2017 |
|
rs8192678
|
PPARGC1A
|
Steatohepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The PPARGC1A rs8192678 GA/AA genotype was associated with higher steatosis grade and presence of ballooning degeneration.
|
27015186 |
2016 |
|
rs8192678
|
PPARGC1A
|
Fatty Liver Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs8192678
|
PPARGC1A
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined PPARγ C1431T, PGC-1α G482S, and LXRα -115G/A polymorphisms increased the risk of CAD and predicted the severity of coronary atherosclerosis in Thais.
|
27016616 |
2016 |
|
rs4235308
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification with sex, in Haitian Americans, both rs4235308</span> (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043).
|
25977930 |
2015 |
|
rs7656250
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043).
|
25977930 |
2015 |
|
rs3736265
|
PPARGC1A
|
Huntington Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
We report that a coding variant (rs3736265) in PPARGC1A is associated with an earlier motor AO in men but not women carrying the HD mutation.
|
24383721 |
2014 |
|
rs8192678
|
PPARGC1A
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, in hypertensive patients, the PPARGC1A Gly482Ser polymorphism is associated with LV hypertrophy and diastolic dysfunction, with the presence of the Ser-Ser allele promoting these abnormalities.
|
24718382 |
2014 |
|
rs3736265
|
PPARGC1A
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs).
|
23335958 |
2013 |
|
rs3774923
|
PPARGC1A
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs).
|
23335958 |
2013 |