|
rs4680
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contribute to estrogen-induced carcinogenesis of breast cancer.
|
20591221 |
2010 |
|
rs4680
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control study was conducted to assess the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer, as well as their combined effects on breast cancer.
|
21438753 |
2011 |
|
rs4680
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with breast cancer risk.
|
19074205 |
2009 |
|
rs4680
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast cancer risks when analyzed individually, COMT wild type (Val(158)Val) in combination with CYP1B1 heterozygous variant (Leu(432)Val) [OR: 0.21; 95% CI (0.05-0.82), p value; 0.021] and COMT heterozygous variant (Val(158)Met) in combination with CYP1B1 wild type (Leu(432)Leu) [OR: 0.29; 95% CI (0.08-0.96), p value; 0.042] showed significant protective association with premenopausal breast cancer risk.
|
20037207 |
2009 |
|
rs4680
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
|
21898113 |
2012 |
|
rs1342715506
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we evaluated the frequency of different polymorphisms related with estrogen metabolism [COMT Val158Met, CYP17 (5'UTR, T27C); HSD17beta1 Gly313Ser and MnSOD Val16Ala] in a breast cancer resistant population, the Xavante Indians, and the frequencies were compared with the ones reported in other populations where breast cancer case-control studies dealing with these polymorphisms have been carried out.
|
16969494 |
2006 |
|
rs1445081098
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined associations between polymorphisms in genes related to estrogen metabolism (CYP1B1 codon 432G --> C rs#1056836, CYP1B1 codon 453A --> G rs#1800440, COMT codon 158G --> A rs#4680) and biosynthesis (CYP17 T --> C promoter rs#743572, CYP19 exon 4 TTTA repeat) and urinary estrogen metabolites (2-hydroxyestrogens (2-OHE), 16alpha-hydroxyestrone (16alpha-OHE1), and their ratio) in a pilot study of 64 pre- and post-menopausal women with a family history of breast cancer.
|
16850246 |
2007 |
|
rs1457049406
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer.
|
15386537 |
2005 |
|
rs2020917
|
COMT;TXNRD2
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Two common SNPs in the distal promoter for membrane-bound (MB) COMT, rs2020917 and rs737865, were associated with breast cancer risk reduction in premenopausal women in the Mayo Clinic study, with allele-specific odds ratios (OR) of 0.70 [95% confidence interval (CI), 0.52-0.95] and 0.68 (95% CI, 0.51-0.92), respectively.
|
18632656 |
2008 |
|
rs4818
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that COMT rs4818, or a variant it tags, is associated with breast cancer prognosis.
|
19551860 |
2009 |
|
rs737865
|
COMT;TXNRD2
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Two common SNPs in the distal promoter for membrane-bound (MB) COMT, rs2020917 and rs737865, were associated with breast cancer risk reduction in premenopausal women in the Mayo Clinic study, with allele-specific odds ratios (OR) of 0.70 [95% confidence interval (CI), 0.52-0.95] and 0.68 (95% CI, 0.51-0.92), respectively.
|
18632656 |
2008 |
|
rs74745580
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the BRCA1 Cys39Gly and CYP17A1 -34T>C</span> genetic variations were associated with breast cancer</span> risk.
|
29510000 |
2018 |
|
rs757163626
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
These data seem to suggest that individuals who never breast fed with MnSOD Val16Ala variant allele are at a lower risk for breast cancer, but larger studies are required to confirm these results.
|
16969494 |
2006 |
|
rs764392202
|
COMT;MIR4761
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the BRCA1 Cys39Gly</span> and CYP17A1 -34T>C genetic variations were associated with breast cancer risk.
|
29510000 |
2018 |