COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Schizophrenia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2020917
rs2020917
Entrez Id: 1312;10587
Gene Symbol: COMT;TXNRD2
COMT;TXNRD2
CUI: C0036341
Disease:
Schizophrenia 		0.010 GeneticVariation BEFREE Two SNPs, rs2020917 (OR=0.54, 95% CI 0.37-0.79; P=0.0011) and rs737865 (OR=0.52, 95% CI 0.36-0.74; P=0.0002), in the P2 promoter region were significantly associated with schizophrenia as well as an increase (increase=11.2%, 95% CI 3.7%-19.2%; P=0.0031) in reporter gene expression. 22705295 2012