COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Mood Disorders ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
Entrez Id: 1312;100616414
Gene Symbol: COMT;MIR4761
COMT;MIR4761
CUI: C0525045
Disease:
Mood Disorders 		0.040 GeneticVariation BEFREE Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders. 25766270 2015
dbSNP: rs4680
rs4680
Entrez Id: 1312;100616414
Gene Symbol: COMT;MIR4761
COMT;MIR4761
CUI: C0525045
Disease:
Mood Disorders 		0.040 GeneticVariation BEFREE COMT Val158Met was not associated with anxiety or mood disorders in either gender. 23928267 2013
dbSNP: rs4680
rs4680
Entrez Id: 1312;100616414
Gene Symbol: COMT;MIR4761
COMT;MIR4761
CUI: C0525045
Disease:
Mood Disorders 		0.040 GeneticVariation BEFREE Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. 22745815 2012
dbSNP: rs4680
rs4680
Entrez Id: 1312;100616414
Gene Symbol: COMT;MIR4761
COMT;MIR4761
CUI: C0525045
Disease:
Mood Disorders 		0.040 GeneticVariation BEFREE The COMT-V158M polymorphism was not associated with suicidal behavior in a Caucasian sample of mood disorder subjects, or with possible clinical or biological endophenotypes. 18828035 2008