COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Breast Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2020917
rs2020917
Entrez Id: 1312;10587
Gene Symbol: COMT;TXNRD2
COMT;TXNRD2
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Two common SNPs in the distal promoter for membrane-bound (MB) COMT, rs2020917 and rs737865, were associated with breast cancer risk reduction in premenopausal women in the Mayo Clinic study, with allele-specific odds ratios (OR) of 0.70 [95% confidence interval (CI), 0.52-0.95] and 0.68 (95% CI, 0.51-0.92), respectively. 18632656 2008